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Insulin regulation of regional free fatty acid metabolism.

  1. S E Meek,
  2. K S Nair and
  3. M D Jensen
  1. Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
    Diabetes 1999 Jan; 48(1): 10-14. https://doi.org/10.2337/diabetes.48.1.10
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    Abstract

    Studies were conducted to determine whether regional free fatty acid (FFA) release is differentially regulated by insulin. Systemic, leg, and splanchnic palmitate rate of appearance ([9,10-(3)H]palmitate) was measured in 26 healthy adults using the euglycemic-hyperinsulinemic clamp technique to achieve a physiological range of plasma insulin concentrations. We found that insulin inhibited systemic, leg, and splanchnic palmitate release in a dose-dependent fashion over the range of insulin infused (0-1.0 mU x kg(-1) x min(-1)). Progressive hyperinsulinemia changed the leg from a net producer to a net FFA consumer, whereas the splanchnic bed converted from a net FFA consumer to a net producer. At the 0.5 mU x kg(-1) x min(-1) insulin infusion rate, leg FFA release was almost completely suppressed, whereas even with the 1.0 mU x kg(-1) x min(-1) insulin infusion rate, splanchnic FFA release decreased by only approximately 65% (P < 0.05 leg vs. splanchnic). These results demonstrate the regional heterogeneity of insulin-regulated FFA release in vivo, and indicate that visceral adipose tissue lipolysis is more resistant to insulin suppression than is leg lipolysis in humans.

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    Insulin regulation of regional free fatty acid metabolism.
    S E Meek, K S Nair, M D Jensen
    Diabetes Jan 1999, 48 (1) 10-14; DOI: 10.2337/diabetes.48.1.10

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    Insulin regulation of regional free fatty acid metabolism.
    S E Meek, K S Nair, M D Jensen
    Diabetes Jan 1999, 48 (1) 10-14; DOI: 10.2337/diabetes.48.1.10
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