Table of Contents

September 01 1999; volume 48 issue 9

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Onset of type 1 diabetes: a dynamical instability.
B Freiesleben De Blasio, P Bak, F Pociot, A E Karlsen and J Nerup

Diabetes 1999 Sep; 48 (9): 1677-1685. https://doi.org/10.2337/diabetes.48.9.1677

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Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.
S Daniel, M Noda, S G Straub and G W Sharp

Diabetes 1999 Sep; 48 (9): 1686-1690. https://doi.org/10.2337/diabetes.48.9.1686

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Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose.
L M Botion and A Green

Diabetes 1999 Sep; 48 (9): 1691-1697. https://doi.org/10.2337/diabetes.48.9.1691

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Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.
B Mahalingam, A Cuesta-Munoz, E A Davis, F M Matschinsky, R W Harrison and I T Weber

Diabetes 1999 Sep; 48 (9): 1698-1705. https://doi.org/10.2337/diabetes.48.9.1698

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Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats.
M S Haque, Y Minokoshi, M Hamai, M Iwai, M Horiuchi and T Shimazu

Diabetes 1999 Sep; 48 (9): 1706-1712. https://doi.org/10.2337/diabetes.48.9.1706

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Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.
A G Murray, R C Nelson, G R Rayat, J F Elliott and G S Korbutt

Diabetes 1999 Sep; 48 (9): 1713-1719. https://doi.org/10.2337/diabetes.48.9.1713

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Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.
I Bergerot, G A Arreaza, M J Cameron, M D Burdick, R M Strieter, S W Chensue, S Chakrabarti and T L Delovitch

Diabetes 1999 Sep; 48 (9): 1720-1729. https://doi.org/10.2337/diabetes.48.9.1720

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Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.
N Giannoukakis, W A Rudert, S C Ghivizzani, A Gambotto, C Ricordi, M Trucco and P D Robbins

Diabetes 1999 Sep; 48 (9): 1730-1736. https://doi.org/10.2337/diabetes.48.9.1730

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Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation.
R P Robertson, D E Sutherland and K J Lanz

Diabetes 1999 Sep; 48 (9): 1737-1740. https://doi.org/10.2337/diabetes.48.9.1737

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Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells.
T Kanno, S Suga, K Nakano, N Kamimura and M Wakui

Diabetes 1999 Sep; 48 (9): 1741-1746. https://doi.org/10.2337/diabetes.48.9.1741

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Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.
Y Q Liu, K Tornheim and J L Leahy

Diabetes 1999 Sep; 48 (9): 1747-1753. https://doi.org/10.2337/diabetes.48.9.1747

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A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.
S A Metz, M Meredith, J Vadakekalam, M E Rabaglia and A Kowluru

Diabetes 1999 Sep; 48 (9): 1754-1762. https://doi.org/10.2337/diabetes.48.9.1754

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Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.
X J Yang, L M Kow, T Funabashi and C V Mobbs

Diabetes 1999 Sep; 48 (9): 1763-1772. https://doi.org/10.2337/diabetes.48.9.1763

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Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells.
J Lou, F Triponez, J Oberholzer, H Wang, D Yu, L Buhler, N Cretin, G Mentha, C B Wollheim and P Morel

Diabetes 1999 Sep; 48 (9): 1773-1778. https://doi.org/10.2337/diabetes.48.9.1773

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Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes.
M P Hermans, J C Levy, R J Morris and R C Turner

Diabetes 1999 Sep; 48 (9): 1779-1786. https://doi.org/10.2337/diabetes.48.9.1779

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Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.
N Satoh, Y Ogawa, G Katsuura, Y Numata, T Tsuji, M Hayase, K Ebihara, H Masuzaki, K Hosoda, Y Yoshimasa and K Nakao

Diabetes 1999 Sep; 48 (9): 1787-1793. https://doi.org/10.2337/diabetes.48.9.1787

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T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.
A Oku, K Ueta, K Arakawa, T Ishihara, M Nawano, Y Kuronuma, M Matsumoto, A Saito, K Tsujihara, M Anai, T Asano, Y Kanai and H Endou

Diabetes 1999 Sep; 48 (9): 1794-1800. https://doi.org/10.2337/diabetes.48.9.1794

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Altered hypothalamic function in response to glucose ingestion in obese humans.
M Matsuda, Y Liu, S Mahankali, Y Pu, A Mahankali, J Wang, R A DeFronzo, P T Fox and J H Gao

Diabetes 1999 Sep; 48 (9): 1801-1806. https://doi.org/10.2337/diabetes.48.9.1801

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Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.
J E Friedman, T Ishizuka, J Shao, L Huston, T Highman and P Catalano

Diabetes 1999 Sep; 48 (9): 1807-1814. https://doi.org/10.2337/diabetes.48.9.1807

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Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans.
S J Bradley, B A Kingwell and G K McConell

Diabetes 1999 Sep; 48 (9): 1815-1821. https://doi.org/10.2337/diabetes.48.9.1815

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Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.
Y Ogawa, H Masuzaki, K Hosoda, M Aizawa-Abe, J Suga, M Suda, K Ebihara, H Iwai, N Matsuoka, N Satoh, H Odaka, H Kasuga, Y Fujisawa, G Inoue, H Nishimura, Y Yoshimasa and K Nakao

Diabetes 1999 Sep; 48 (9): 1822-1829. https://doi.org/10.2337/diabetes.48.9.1822

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Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice.
Y Tang, H Osawa, H Onuma, T Nishimiya, M Ochi and H Makino

Diabetes 1999 Sep; 48 (9): 1830-1835. https://doi.org/10.2337/diabetes.48.9.1830

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Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.
A T Santomauro, G Boden, M E Silva, D M Rocha, R F Santos, M J Ursich, P G Strassmann and B L Wajchenberg

Diabetes 1999 Sep; 48 (9): 1836-1841. https://doi.org/10.2337/diabetes.48.9.1836

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Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.
R Shibayama, N Araki, R Nagai and S Horiuchi

Diabetes 1999 Sep; 48 (9): 1842-1849. https://doi.org/10.2337/diabetes.48.9.1842

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Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients.
S K Jain and R McVie

Diabetes 1999 Sep; 48 (9): 1850-1855. https://doi.org/10.2337/diabetes.48.9.1850

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Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.
A E Caballero, S Arora, R Saouaf, S C Lim, P Smakowski, J Y Park, G L King, F W LoGerfo, E S Horton and A Veves

Diabetes 1999 Sep; 48 (9): 1856-1862. https://doi.org/10.2337/diabetes.48.9.1856

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A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor.
B D Mitchell, S A Cole, A G Comuzzie, L Almasy, J Blangero, J W MacCluer and J E Hixson

Diabetes 1999 Sep; 48 (9): 1863-1867. https://doi.org/10.2337/diabetes.48.9.1863

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Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study.
H H Lei, J Coresh, A R Shuldiner, E Boerwinkle and F L Brancati

Diabetes 1999 Sep; 48 (9): 1868-1872. https://doi.org/10.2337/diabetes.48.9.1868

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Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels.
L Héron, A Virsolvy, F Apiou, A Le Cam and D Bataille

Diabetes 1999 Sep; 48 (9): 1873-1876. https://doi.org/10.2337/diabetes.48.9.1873

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Human insulin receptor substrate-2: gene organization and promoter characterization.
L Vassen, W Wegrzyn and L Klein-Hitpass

Diabetes 1999 Sep; 48 (9): 1877-1880. https://doi.org/10.2337/diabetes.48.9.1877

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A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.
A Pizzuti, L Frittitta, A Argiolas, R Baratta, I D Goldfine, M Bozzali, T Ercolino, G Scarlato, L Iacoviello, R Vigneri, V Tassi and V Trischitta

Diabetes 1999 Sep; 48 (9): 1881-1884. https://doi.org/10.2337/diabetes.48.9.1881

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Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.
J E Ayala, R S Streeper, J S Desgrosellier, S K Durham, A Suwanichkul, C A Svitek, J K Goldman, F G Barr, D R Powell and R M O'Brien

Diabetes 1999 Sep; 48 (9): 1885-1889. https://doi.org/10.2337/diabetes.48.9.1885

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Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.
W K Chung, A Luke, R S Cooper, C Rotini, A Vidal-Puig, M Rosenbaum, M Chua, G Solanes, M Zheng, L Zhao, C LeDuc, A Eisberg, F Chu, E Murphy, M Schreier, L Aronne, S Caprio, B Kahle, D Gordon, S M Leal, R Goldsmith, A L Andreu, C Bruno, S DiMauro and R L Leibel

Diabetes 1999 Sep; 48 (9): 1890-1895. https://doi.org/10.2337/diabetes.48.9.1890

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