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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

  1. N Kubota,
  2. K Tobe,
  3. Y Terauchi,
  4. K Eto,
  5. T Yamauchi,
  6. R Suzuki,
  7. Y Tsubamoto,
  8. K Komeda,
  9. R Nakano,
  10. H Miki,
  11. S Satoh,
  12. H Sekihara,
  13. S Sciacchitano,
  14. M Lesniak,
  15. S Aizawa,
  16. R Nagai,
  17. S Kimura,
  18. Y Akanuma,
  19. S I Taylor and
  20. T Kadowaki
  1. Department of Metabolic Disease, Graduate School of Medicine, University of Tokyo, Japan.
    Diabetes 2000 Nov; 49(11): 1880-1889. https://doi.org/10.2337/diabetes.49.11.1880
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    Abstract

    To investigate the role of insulin receptor substrate (IRS)-2 in vivo, we generated IRS-2-deficient mice by gene targeting. Although homozygous IRS-2-deficient mice (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. IRS-2-/- mice showed insulin resistance and a defect in the insulin-stimulated signaling pathway in liver but not in skeletal muscle. Despite insulin resistance, the amount of beta-cells was reduced to 83% of that in wild-type mice, which was in marked contrast to the 85% increase in the amount of beta-cells in IRS-1-deficient mice (IRS-1-/- mice) to compensate for insulin resistance. Thus, IRS-2 plays a crucial role in the regulation of beta-cell mass. On the other hand, insulin secretion by the same number of cells in response to glucose measured ex vivo was significantly increased in IRS-2-/- mice compared with wild-type mice but was decreased in IRS-1-/- mice. These results suggest that IRS-1 and IRS-2 may play different roles in the regulation of beta-cell mass and the function of individual beta-cells.

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    Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
    N Kubota, K Tobe, Y Terauchi, K Eto, T Yamauchi, R Suzuki, Y Tsubamoto, K Komeda, R Nakano, H Miki, S Satoh, H Sekihara, S Sciacchitano, M Lesniak, S Aizawa, R Nagai, S Kimura, Y Akanuma, S I Taylor, T Kadowaki
    Diabetes Nov 2000, 49 (11) 1880-1889; DOI: 10.2337/diabetes.49.11.1880

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    Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
    N Kubota, K Tobe, Y Terauchi, K Eto, T Yamauchi, R Suzuki, Y Tsubamoto, K Komeda, R Nakano, H Miki, S Satoh, H Sekihara, S Sciacchitano, M Lesniak, S Aizawa, R Nagai, S Kimura, Y Akanuma, S I Taylor, T Kadowaki
    Diabetes Nov 2000, 49 (11) 1880-1889; DOI: 10.2337/diabetes.49.11.1880
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