Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

N Kubota; K Tobe; Y Terauchi; K Eto; T Yamauchi; R Suzuki; Y Tsubamoto; K Komeda; R Nakano; H Miki; S Satoh; H Sekihara; S Sciacchitano; M Lesniak; S Aizawa; R Nagai; S Kimura; Y Akanuma; S I Taylor; T Kadowaki

doi:10.2337/diabetes.49.11.1880

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

N Kubota,
K Tobe,
Y Terauchi,
K Eto,
T Yamauchi,
R Suzuki,
Y Tsubamoto,
K Komeda,
R Nakano,
H Miki,
S Satoh,
H Sekihara,
S Sciacchitano,
M Lesniak,
S Aizawa,
R Nagai,
S Kimura,
Y Akanuma,
S I Taylor and
T Kadowaki

Department of Metabolic Disease, Graduate School of Medicine, University of Tokyo, Japan.

Diabetes 2000 Nov; 49(11): 1880-1889. https://doi.org/10.2337/diabetes.49.11.1880

Article Information

vol. 49 no. 11 1880-1889

DOI

https://doi.org/10.2337/diabetes.49.11.1880

PubMed

11078455

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Published in print November 1, 2000.

Author Information

N Kubota,
K Tobe,
Y Terauchi,
K Eto,
T Yamauchi,
R Suzuki,
Y Tsubamoto,
K Komeda,
R Nakano,
H Miki,
S Satoh,
H Sekihara,
S Sciacchitano,
M Lesniak,
S Aizawa,
R Nagai,
S Kimura,
Y Akanuma,
S I Taylor and
T Kadowaki

Department of Metabolic Disease, Graduate School of Medicine, University of Tokyo, Japan.

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Jul 2001	7	0	56
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Feb 2003	10	0	42
Mar 2003	0	0	29
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May 2003	15	0	55
Jun 2003	19	1	48
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Oct 2004	12	0	54
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Jan 2005	23	0	57
Feb 2005	25	1	66
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Jun 2005	8	0	23
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Jan 2008	4	0	33
Feb 2008	12	0	22
Mar 2008	20	0	36
Apr 2008	26	0	66
May 2008	25	0	50
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Jul 2008	14	0	38
Aug 2008	22	0	21
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Jan 2009	20	0	30
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Mar 2009	49	0	56
Apr 2009	37	0	67
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Jun 2009	19	0	49
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Jul 2013	29	1	61
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May 2014	78	0	134
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Feb 2018	36	0	20
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Jan 2019	50	0	47
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Jun 2019	33	0	30
Jul 2019	33	0	38
Aug 2019	42	0	27
Sep 2019	27	0	12

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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