Table of Contents

July 01 2000; volume 49 issue 7

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Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes.
R L Bradley, E G Kokkotou, E Maratos-Flier and B Cheatham

Diabetes 2000 Jul; 49 (7): 1073-1077. https://doi.org/10.2337/diabetes.49.7.1073

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Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.
P N Båvenholm, J Pigon, A K Saha, N B Ruderman and S Efendic

Diabetes 2000 Jul; 49 (7): 1078-1083. https://doi.org/10.2337/diabetes.49.7.1078

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Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.
P Nuutila, P Peltoniemi, V Oikonen, K Larmola, J Kemppainen, T Takala, H Sipilä, A Oksanen, U Ruotsalainen, G B Bolli and H Yki-Järvinen

Diabetes 2000 Jul; 49 (7): 1084-1091. https://doi.org/10.2337/diabetes.49.7.1084

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Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.
J R Daugaard, J N Nielsen, S Kristiansen, J L Andersen, M Hargreaves and E A Richter

Diabetes 2000 Jul; 49 (7): 1092-1095. https://doi.org/10.2337/diabetes.49.7.1092

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Glycogen synthase sensitivity to insulin and glucose-6-phosphate is mediated by both NH2- and COOH-terminal phosphorylation sites.
A V Skurat, A D Dietrich and P J Roach

Diabetes 2000 Jul; 49 (7): 1096-1100. https://doi.org/10.2337/diabetes.49.7.1096

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Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle.
I Cusin, J Rouru, T Visser, A G Burger and F Rohner-Jeanrenaud

Diabetes 2000 Jul; 49 (7): 1101-1105. https://doi.org/10.2337/diabetes.49.7.1101

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Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice.
D G Alleva, R P Pavlovich, C Grant, S B Kaser and D I Beller

Diabetes 2000 Jul; 49 (7): 1106-1115. https://doi.org/10.2337/diabetes.49.7.1106

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Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
D Liu, D Pavlovic, M C Chen, M Flodström, S Sandler and D L Eizirik

Diabetes 2000 Jul; 49 (7): 1116-1122. https://doi.org/10.2337/diabetes.49.7.1116

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Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.
S Lortz, M Tiedge, T Nachtwey, A E Karlsen, J Nerup and S Lenzen

Diabetes 2000 Jul; 49 (7): 1123-1130. https://doi.org/10.2337/diabetes.49.7.1123

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K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin.
M Kullin, Z Li, J B Hansen, E Björk, S Sandler and F A Karlsson

Diabetes 2000 Jul; 49 (7): 1131-1136. https://doi.org/10.2337/diabetes.49.7.1131

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Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
J Seissler, T B Nguyen, G Aust, H Steinbrenner and W A Scherbaum

Diabetes 2000 Jul; 49 (7): 1137-1141. https://doi.org/10.2337/diabetes.49.7.1137

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Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.
N Ban, Y Yamada, Y Someya, Y Ihara, T Adachi, A Kubota, R Watanabe, A Kuroe, A Inada, K Miyawaki, Y Sunaga, Z P Shen, T Iwakura, K Tsukiyama, S Toyokuni, K Tsuda and Y Seino

Diabetes 2000 Jul; 49 (7): 1142-1148. https://doi.org/10.2337/diabetes.49.7.1142

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Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.
E K Ainscow, C Zhao and G A Rutter

Diabetes 2000 Jul; 49 (7): 1149-1155. https://doi.org/10.2337/diabetes.49.7.1149

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Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.
G Skoglund, M A Hussain and G G Holz

Diabetes 2000 Jul; 49 (7): 1156-1164. https://doi.org/10.2337/diabetes.49.7.1156

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Induction of PEPCK gene expression in insulinopenia in rat small intestine.
F Rajas, M Croset, C Zitoun, S Montano and G Mithieux

Diabetes 2000 Jul; 49 (7): 1165-1168. https://doi.org/10.2337/diabetes.49.7.1165

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Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.
S Jackson, S M Bagstaff, S Lynn, S J Yeaman, D M Turnbull and M Walker

Diabetes 2000 Jul; 49 (7): 1169-1177. https://doi.org/10.2337/diabetes.49.7.1169

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Muscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.
M Niklasson, A Holmäng, M Sjöstrand, L Strindberg and P Lönnroth

Diabetes 2000 Jul; 49 (7): 1178-1185. https://doi.org/10.2337/diabetes.49.7.1178

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Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans.
E Cersosimo, P Garlick and J Ferretti

Diabetes 2000 Jul; 49 (7): 1186-1193. https://doi.org/10.2337/diabetes.49.7.1186

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The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.
M Caruso, C Miele, A Oliva, G Condorelli, F Oriente, G Riccardi, B Capaldo, F Fiory, D Accili, P Formisano and F Beguinot

Diabetes 2000 Jul; 49 (7): 1194-1202. https://doi.org/10.2337/diabetes.49.7.1194

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Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.
R S Surwit, C L Edwards, S Murthy and A E Petro

Diabetes 2000 Jul; 49 (7): 1203-1208. https://doi.org/10.2337/diabetes.49.7.1203

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Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients.
J E Henriksen, K Levin, P Thye-Rønn, F Alford, O Hother-Nielsen, J J Holst and H Beck-Nielsen

Diabetes 2000 Jul; 49 (7): 1209-1218. https://doi.org/10.2337/diabetes.49.7.1209

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Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.
B Burguera, M E Couce, G L Curran, M D Jensen, R V Lloyd, M P Cleary and J F Poduslo

Diabetes 2000 Jul; 49 (7): 1219-1223. https://doi.org/10.2337/diabetes.49.7.1219

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Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
N Pedraza, G Solanes, M C Carmona, R Iglesias, O Viñas, T Mampel, M Vazquez, M Giralt and F Villarroya

Diabetes 2000 Jul; 49 (7): 1224-1230. https://doi.org/10.2337/diabetes.49.7.1224

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Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.
H O Steinberg, G Paradisi, G Hook, K Crowder, J Cronin and A D Baron

Diabetes 2000 Jul; 49 (7): 1231-1238. https://doi.org/10.2337/diabetes.49.7.1231

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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
J Y Park, N Takahara, A Gabriele, E Chou, K Naruse, K Suzuma, T Yamauchi, S W Ha, M Meier, C J Rhodes and G L King

Diabetes 2000 Jul; 49 (7): 1239-1248. https://doi.org/10.2337/diabetes.49.7.1239

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The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.
G Pugliese, F Pricci, G Leto, L Amadio, C Iacobini, G Romeo, L Lenti, P Sale, R Gradini, F T Liu and U Di Mario

Diabetes 2000 Jul; 49 (7): 1249-1257. https://doi.org/10.2337/diabetes.49.7.1249

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Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.
F Chiarelli, F Cipollone, F Romano, S Tumini, F Costantini, L di Ricco, M Pomilio, S D Pierdomenico, M Marini, F Cuccurullo and A Mezzetti

Diabetes 2000 Jul; 49 (7): 1258-1263. https://doi.org/10.2337/diabetes.49.7.1258

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Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.
H Rau, M Kocova, S O'Rahilly and J P Whitehead

Diabetes 2000 Jul; 49 (7): 1264-1268. https://doi.org/10.2337/diabetes.49.7.1264

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A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.
M Tawata, J I Hayashi, K Isobe, E Ohkubo, M Ohtaka, J Chen, K Aida and T Onaya

Diabetes 2000 Jul; 49 (7): 1269-1272. https://doi.org/10.2337/diabetes.49.7.1269

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