Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes: How High Must the Standards Be Set?

Philippe A. Halban; Steven E. Kahn; Åke Lernmark; Christopher J. Rhodes

doi:10.2337/diabetes.50.10.2181

Perspectives in Diabetes

Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes

How High Must the Standards Be Set?

Philippe A. Halban1,
Steven E. Kahn2,
Åke Lernmark3 and
Christopher J. Rhodes4

¹Louis-Jeantet Research Laboratories, University Medical Center, Geneva, Switzerland
²Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington
³Robert H. Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington
⁴Pacific Northwest Research Institute, Seattle, Washington

Diabetes 2001 Oct; 50(10): 2181-2191. https://doi.org/10.2337/diabetes.50.10.2181

Article Information

vol. 50 no. 10 2181-2191

DOI

https://doi.org/10.2337/diabetes.50.10.2181

PubMed

11574396

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Published in print October 1, 2001.

Author Information

Philippe A. Halban1,
Steven E. Kahn2,
Åke Lernmark3 and
Christopher J. Rhodes4

¹Louis-Jeantet Research Laboratories, University Medical Center, Geneva, Switzerland
²Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington
³Robert H. Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington
⁴Pacific Northwest Research Institute, Seattle, Washington

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: September 2001 to April 2021

Rendering graph...

	Abstract	Full	Pdf
Sep 2001	135	152	25
Oct 2001	239	641	101
Nov 2001	73	242	65
Dec 2001	25	166	25
Jan 2002	37	173	15
Feb 2002	36	113	13
Mar 2002	39	126	12
Apr 2002	32	98	19
May 2002	16	78	19
Jun 2002	14	52	10
Jul 2002	19	53	7
Aug 2002	15	51	19
Sep 2002	13	57	16
Oct 2002	19	59	39
Nov 2002	15	83	55
Dec 2002	12	60	53
Jan 2003	3	46	38
Feb 2003	20	38	27
Mar 2003	8	46	29
Apr 2003	16	45	32
May 2003	21	54	52
Jun 2003	17	35	28
Jul 2003	15	52	44
Aug 2003	17	57	25
Sep 2003	24	49	16
Oct 2003	22	71	48
Nov 2003	36	75	25
Dec 2003	15	47	22
Jan 2004	17	58	28
Feb 2004	25	80	30
Mar 2004	34	105	32
Apr 2004	16	97	22
May 2004	47	109	35
Jun 2004	45	85	31
Jul 2004	42	96	22
Aug 2004	53	100	17
Sep 2004	22	84	20
Oct 2004	30	128	45
Nov 2004	29	158	38
Dec 2004	37	121	15
Jan 2005	41	169	28
Feb 2005	30	174	39
Mar 2005	46	268	44
Apr 2005	22	124	43
May 2005	10	178	34
Jun 2005	32	75	29
Jul 2005	12	73	19
Aug 2005	20	95	42
Sep 2005	16	115	27
Oct 2005	19	111	22
Nov 2005	25	169	42
Dec 2005	13	144	28
Jan 2006	20	120	17
Feb 2006	10	148	21
Mar 2006	7	198	26
Apr 2006	14	82	15
May 2006	47	49	26
Jun 2006	15	42	8
Jul 2006	28	43	14
Aug 2006	8	16	17
Sep 2006	8	42	7
Oct 2006	7	53	15
Nov 2006	13	59	17
Dec 2006	10	60	14
Jan 2007	11	32	11
Feb 2007	15	53	22
Mar 2007	20	117	12
Apr 2007	14	66	24
May 2007	16	49	23
Jun 2007	14	48	18
Jul 2007	18	45	14
Aug 2007	16	25	12
Sep 2007	14	35	6
Oct 2007	31	62	16
Nov 2007	21	52	15
Dec 2007	32	58	14
Jan 2008	14	28	19
Feb 2008	20	42	17
Mar 2008	22	35	17
Apr 2008	35	63	21
May 2008	36	41	22
Jun 2008	38	42	13
Jul 2008	27	30	10
Aug 2008	22	34	9
Sep 2008	31	36	13
Oct 2008	17	32	13
Nov 2008	28	49	25
Dec 2008	16	34	15
Jan 2009	11	23	12
Feb 2009	12	27	15
Mar 2009	21	32	21
Apr 2009	15	31	11
May 2009	12	31	11
Jun 2009	21	11	5
Jul 2009	21	29	18
Aug 2009	18	23	10
Sep 2009	25	40	16
Oct 2009	46	26	14
Nov 2009	35	42	19
Dec 2009	30	38	19
Jan 2010	39	48	22
Feb 2010	31	23	12
Mar 2010	27	64	13
Apr 2010	49	42	15
May 2010	22	52	12
Jun 2010	9	51	10
Jul 2010	23	37	12
Aug 2010	21	40	15
Sep 2010	33	43	8
Oct 2010	23	58	8
Nov 2010	25	49	17
Dec 2010	16	35	16
Jan 2011	23	47	10
Feb 2011	17	35	11
Mar 2011	57	78	16
Apr 2011	30	56	14
May 2011	37	44	23
Jun 2011	37	37	15
Jul 2011	31	33	21
Aug 2011	33	42	22
Sep 2011	27	44	15
Oct 2011	36	64	28
Nov 2011	31	85	14
Dec 2011	50	48	20
Jan 2012	34	53	23
Feb 2012	43	59	21
Mar 2012	55	63	33
Apr 2012	62	100	28
May 2012	32	67	26
Jun 2012	34	45	17
Jul 2012	34	46	11
Aug 2012	40	47	19
Sep 2012	40	46	16
Oct 2012	40	73	15
Nov 2012	44	90	13
Dec 2012	39	79	7
Jan 2013	42	120	17
Feb 2013	55	228	28
Mar 2013	46	205	19
Apr 2013	77	272	31
May 2013	54	295	26
Jun 2013	34	141	15
Jul 2013	28	107	13
Aug 2013	18	66	10
Sep 2013	27	91	10
Oct 2013	23	135	17
Nov 2013	38	135	8
Dec 2013	23	134	12
Jan 2014	41	183	16
Feb 2014	19	301	17
Mar 2014	21	614	35
Apr 2014	53	669	32
May 2014	36	695	25
Jun 2014	56	290	16
Jul 2014	43	229	14
Aug 2014	15	220	25
Sep 2014	24	295	17
Oct 2014	29	265	20
Nov 2014	40	355	18
Dec 2014	20	217	19
Jan 2015	22	348	27
Feb 2015	15	374	18
Mar 2015	68	525	30
Apr 2015	26	483	23
May 2015	16	469	13
Jun 2015	21	232	19
Jul 2015	20	312	21
Aug 2015	12	306	11
Sep 2015	26	306	24
Oct 2015	23	380	20
Nov 2015	20	491	25
Dec 2015	23	451	39
Jan 2016	22	458	15
Feb 2016	46	758	39
Mar 2016	107	667	30
Apr 2016	58	680	36
May 2016	44	763	41
Jun 2016	10	482	49
Jul 2016	9	376	44
Aug 2016	15	398	42
Sep 2016	16	393	44
Oct 2016	20	411	45
Nov 2016	21	509	40
Dec 2016	14	425	49
Jan 2017	8	381	18
Feb 2017	7	564	25
Mar 2017	3	707	21
Apr 2017	9	280	22
May 2017	9	206	11
Jun 2017	4	142	10
Jul 2017	6	140	11
Aug 2017	9	211	4
Sep 2017	14	251	8
Oct 2017	6	368	30
Nov 2017	8	315	14
Dec 2017	5	179	15
Jan 2018	5	205	15
Feb 2018	7	241	13
Mar 2018	13	276	19
Apr 2018	8	244	11
May 2018	3	189	6
Jun 2018	1	197	9
Jul 2018	0	174	9
Aug 2018	2	159	6
Sep 2018	3	298	10
Oct 2018	8	429	17
Nov 2018	5	476	26
Dec 2018	4	306	5
Jan 2019	7	232	10
Feb 2019	6	247	8
Mar 2019	11	309	17
Apr 2019	7	154	27
May 2019	19	123	12
Jun 2019	4	95	16
Jul 2019	4	120	14
Aug 2019	6	167	18
Sep 2019	4	121	10
Oct 2019	9	209	17
Nov 2019	6	167	14
Dec 2019	3	98	23
Jan 2020	2	86	9
Feb 2020	6	79	10
Mar 2020	10	81	15
Apr 2020	3	135	10
May 2020	5	104	5
Jun 2020	5	122	9
Jul 2020	3	82	16
Aug 2020	2	58	8
Sep 2020	0	90	7
Oct 2020	7	97	15
Nov 2020	12	148	13
Dec 2020	7	151	11
Jan 2021	1	111	7
Feb 2021	5	147	17
Mar 2021	3	228	28
Apr 2021	1	73	8