Hypoglycemic Detection Does Not Occur in the Hepatic Artery or Liver
Findings Consistent With a Portal Vein Glucosensor Locus
Article Figures & Tables
Figures
- FIG. 1.
Schematic diagram of the two glucose infusion conditions. A: PER protocol represents the control experiment in which whole-body hypoglycemia was induced. B: HA protocol allowed for the elevation of hepatic artery and the normalization of liver glucose concentrations during systemic hypoglycemia. Bar graphs represent the target glycemias for arterial circulation (carotid artery sampling), portal vein, liver, and hepatic artery during both glucose infusion experiments.
- FIG. 2.
Data are means ± SE for arterial plasma glucose (A), hepatic plasma glucose (B), portal vein plasma glucose (C), and hepatic artery glucose (D) at basal and during the hyperinsulinemic-hypoglycemic clamp. ▵, HA protocol; ▴, PER protocol. *P < 0.05 between infusion protocols.
- FIG. 3.
Average values (means ± SE) for epinephrine (A) and norepinephrine (B) concentrations at basal (stage 1) and during progressive hypoglycemic stages (stages 2-7). Stages are 40-min periods. Average values were determined from three samples taken 10 min apart during each sampling stage. □, HA protocol; ▪, PER protocol. No significant differences were observed between infusion protocols.
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