Diabetes: 50 (4)

April 01 2001; volume 50 issue 4

Rapid Publication

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Circulating Ghrelin Levels Are Decreased in Human Obesity
Matthias Tschöp, Christian Weyer, P. Antonio Tataranni, Viswanath Devanarayan, Eric Ravussin and Mark L. Heiman

Diabetes 2001 Apr; 50 (4): 707-709. https://doi.org/10.2337/diabetes.50.4.707

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Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol
Edmond A. Ryan, Jonathan R.T. Lakey, Ray V. Rajotte, Gregory S. Korbutt, Tatsuya Kin, Sharleen Imes, Alex Rabinovitch, John F. Elliott, David Bigam, Norman M. Kneteman, Garth L. Warnock, Ingrid Larsen and A.M. James Shapiro

Diabetes 2001 Apr; 50 (4): 710-719. https://doi.org/10.2337/diabetes.50.4.710

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Metabolism and Signal Transduction

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Control of Glycogen Synthesis by Glucose, Glycogen, and Insulin in Cultured Human Muscle Cells
Reza Halse, Sylvie M. Bonavaud, Jane L. Armstrong, James G. McCormack and Stephen J. Yeaman

Diabetes 2001 Apr; 50 (4): 720-726. https://doi.org/10.2337/diabetes.50.4.720

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In Normal Men, Free Fatty Acids Reduce Peripheral but Not Splanchnic Glucose Uptake
Vincent Rigalleau, Christophe Binnert, Kaori Minehira, Nathalie Stefanoni, Phillippe Schneiter, Emmanuel Henchoz, Oscar Matzinger, Christine Cayeux, Eric Jéquier and Luc Tappy

Diabetes 2001 Apr; 50 (4): 727-732. https://doi.org/10.2337/diabetes.50.4.727

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Cerulenin Mimics Effects of Leptin on Metabolic Rate, Food Intake, and Body Weight Independent of the Melanocortin System, but Unlike Leptin, Cerulenin Fails to Block Neuroendocrine Effects of Fasting
Hideo Makimura, Tooru M. Mizuno, Xue-Jun Yang, Jeff Silverstein, Joe Beasley and Charles V. Mobbs

Diabetes 2001 Apr; 50 (4): 733-739. https://doi.org/10.2337/diabetes.50.4.733

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Rat Small Intestine Is an Insulin-Sensitive Gluconeogenic Organ
Martine Croset, Fabienne Rajas, Carine Zitoun, Jean-Marc Hurot, Sandrine Montano and Gilles Mithieux

Diabetes 2001 Apr; 50 (4): 740-746. https://doi.org/10.2337/diabetes.50.4.740

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Assessment of Postabsorptive Renal Glucose Metabolism in Humans With Multiple Glucose Tracers
Niels Moller, Robert A. Rizza, G. Charles Ford and K. Sreekumaran Nair

Diabetes 2001 Apr; 50 (4): 747-751. https://doi.org/10.2337/diabetes.50.4.747

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Immunology and Transplantation

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Autoantibody Response to CD38 in Caucasian Patients With Type 1 and Type 2 DiabetesImmunological and Genetic Characterization
Roberto Mallone, Erika Ortolan, Germano Baj, Ada Funaro, Sara Giunti, Emma Lillaz, Franca Saccucci, Maurizio Cassader, Paolo Cavallo-Perin and Fabio Malavasi

Diabetes 2001 Apr; 50 (4): 752-762. https://doi.org/10.2337/diabetes.50.4.752

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Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice
Priscilla P.L. Chiu, David V. Serreze and Jayne S. Danska

Diabetes 2001 Apr; 50 (4): 763-770. https://doi.org/10.2337/diabetes.50.4.763

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Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route
Arno Hänninen, Andrea Braakhuis, William R. Heath and Leonard C. Harrison

Diabetes 2001 Apr; 50 (4): 771-775. https://doi.org/10.2337/diabetes.50.4.771

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Islet Studies

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Glucagon-Like Peptide 1 Increases Secretory Burst Mass of Pulsatile Insulin Secretion in Patients With Type 2 Diabetes and Impaired Glucose Tolerance
Robert Ritzel, Miriam Schulte, Niels Pørksen, Markus S. Nauck, Jens J. Holst, Claus Juhl, Winfried März, Ole Schmitz, Wolff H. Schmiegel and Michael A. Nauck

Diabetes 2001 Apr; 50 (4): 776-784. https://doi.org/10.2337/diabetes.50.4.776

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Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells
Hongxiang Hui, Chris Wright and Riccardo Perfetti

Diabetes 2001 Apr; 50 (4): 785-796. https://doi.org/10.2337/diabetes.50.4.785

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The Novel Imidazoline Compound BL11282 Potentiates Glucose-Induced Insulin Secretion in Pancreatic β-Cells in the Absence of Modulation of K_ATP Channel Activity
Alexander M. Efanov, Sergei V. Zaitsev, Hans-Juergen Mest, Achim Raap, Ioulia B. Appelskog, Olof Larsson, Per-Olof Berggren and Suad Efendic

Diabetes 2001 Apr; 50 (4): 797-802. https://doi.org/10.2337/diabetes.50.4.797

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Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?
Nathalie Lameloise, Patrick Muzzin, Marc Prentki and Françoise Assimacopoulos-Jeannet

Diabetes 2001 Apr; 50 (4): 803-809. https://doi.org/10.2337/diabetes.50.4.803

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Pathophysiology

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Effects of Free Fatty Acids on Gluconeogenesis and Autoregulation of Glucose Production in Type 2 Diabetes
Guenther Boden, Xinhua Chen, Edwin Capulong and Maria Mozzoli

Diabetes 2001 Apr; 50 (4): 810-816. https://doi.org/10.2337/diabetes.50.4.810

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Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity
Jing He, Simon Watkins and David E. Kelley

Diabetes 2001 Apr; 50 (4): 817-823. https://doi.org/10.2337/diabetes.50.4.817

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A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo
Vara Prasad Manchem, Ira D. Goldfine, Ronald A. Kohanski, Cristina P. Cristobal, Robert T. Lum, Steven R. Schow, Songyuan Shi, Wayne R. Spevak, Edgardo Laborde, Deborah K. Toavs, Hugo O. Villar, Michael M. Wick and Michael R. Kozlowski

Diabetes 2001 Apr; 50 (4): 824-830. https://doi.org/10.2337/diabetes.50.4.824

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The Q Allele Variant (GLN¹²¹) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS¹²¹)
Benedetta V. Costanzo, Vincenzo Trischitta, Rosa Di Paola, Daniela Spampinato, Antonio Pizzuti, Riccardo Vigneri and Lucia Frittitta

Diabetes 2001 Apr; 50 (4): 831-836. https://doi.org/10.2337/diabetes.50.4.831

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Complications

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Increased QTc Dispersion Is Related to Blunted Circadian Blood Pressure Variation in Normoalbuminuric Type 1 Diabetic Patients
Per Løgstrup Poulsen, Eva Ebbehøj, Hanne Arildsen, Søren Tang Knudsen, Klaus Würgler Hansen, Henning Mølgaard and Carl Erik Mogensen

Diabetes 2001 Apr; 50 (4): 837-842. https://doi.org/10.2337/diabetes.50.4.837

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Effect of 3 Years of Antihypertensive Therapy on Renal Structure in Type 1 Diabetic Patients With AlbuminuriaThe European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT)
The European Study for the Prevention of Renal Disease in Type 1 Diabetes ESPRIT Study Group

Diabetes 2001 Apr; 50 (4): 843-850. https://doi.org/10.2337/diabetes.50.4.843

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Diabetes Accelerates Smooth Muscle Accumulation in Lesions of AtherosclerosisLack of Direct Growth-Promoting Effects of High Glucose Levels
Lucy A. Suzuki, Martin Poot, Ross G. Gerrity and Karin E. Bornfeldt

Diabetes 2001 Apr; 50 (4): 851-860. https://doi.org/10.2337/diabetes.50.4.851

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Familial Aggregation of Coronary Artery Calcium in Families With Type 2 Diabetes
Lynne E. Wagenknecht, Donald W. Bowden, J. Jeffrey Carr, Carl D. Langefeld, Barry I. Freedman and Stephen S. Rich

Diabetes 2001 Apr; 50 (4): 861-866. https://doi.org/10.2337/diabetes.50.4.861

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Angiotensin II Induces Expression of the Tie2 Receptor Ligand, Angiopoietin-2, in Bovine Retinal Endothelial Cells
Atsushi Otani, Hitoshi Takagi, Hideyasu Oh, Shinji Koyama and Yoshihito Honda

Diabetes 2001 Apr; 50 (4): 867-875. https://doi.org/10.2337/diabetes.50.4.867

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Genetics

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Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ₂ Gene Is Associated With Increased Antilipolytic Insulin Sensitivity
Michael Stumvoll, Hans Günther Wahl, Klaus Löblein, Regine Becker, Fausto Machicao, Stephan Jacob and Hans Häring

Diabetes 2001 Apr; 50 (4): 876-881. https://doi.org/10.2337/diabetes.50.4.876

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Brief Genetics Report

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The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans
Michael Stumvoll, Andreas Fritsche, Annette Volk, Norbert Stefan, Alexander Madaus, Elke Maerker, Anna Teigeler, Matthias Koch, Fausto Machicao and Hans Häring

Diabetes 2001 Apr; 50 (4): 882-885. https://doi.org/10.2337/diabetes.50.4.882

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The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala VariantAssociation With Type 2 Diabetes and Trait Differences
Julie A. Douglas, Michael R. Erdos, Richard M. Watanabe, Andi Braun, Cristy L. Johnston, Paul Oeth, Karen L. Mohlke, Timo T. Valle, Christian Ehnholm, Thomas A. Buchanan, Richard N. Bergman, Francis S. Collins, Michael Boehnke and Jaakko Tuomilehto

Diabetes 2001 Apr; 50 (4): 886-890. https://doi.org/10.2337/diabetes.50.4.886

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The Pro¹²→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General PopulationPossible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes
Hiroyuki Mori, Hiroshi Ikegami, Yoshihiko Kawaguchi, Susumu Seino, Norihide Yokoi, Jun Takeda, Ituro Inoue, Yutaka Seino, Koichiro Yasuda, Toshiaki Hanafusa, Kazuya Yamagata, Takuya Awata, Takashi Kadowaki, Kazuo Hara, Nobuhiro Yamada, Takanari Gotoda, Naoko Iwasaki, Yasuhiko Iwamoto, Tokio Sanke, Kishio Nanjo, Yoshitomo Oka, Akira Matsutani, Eiichi Maeda and Masato Kasuga

Diabetes 2001 Apr; 50 (4): 891-894. https://doi.org/10.2337/diabetes.50.4.891

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Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen
Juan Diez, Yongsoo Park, Markus Zeller, Douglas Brown, David Garza, Camillo Ricordi, John Hutton, George S. Eisenbarth and Alberto Pugliese

Diabetes 2001 Apr; 50 (4): 895-900. https://doi.org/10.2337/diabetes.50.4.895

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A Ser311Cys Mutation in the Human Dopamine Receptor D2 Gene Is Associated With Reduced Energy Expenditure
P. Antonio Tataranni, Leslie Baier, Chris Jenkinson, Inge Harper, Angelo Del Parigi and Clifton Bogardus

Diabetes 2001 Apr; 50 (4): 901-904. https://doi.org/10.2337/diabetes.50.4.901

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Letter to the Editor

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Measurements of Renal Glucose Release
John E. Gerich

Diabetes 2001 Apr; 50 (4): 905. https://doi.org/10.2337/diabetes.50.4.905

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Table of Contents

Rapid Publication

Metabolism and Signal Transduction

Immunology and Transplantation

Islet Studies

Pathophysiology

Complications

Genetics

Brief Genetics Report

Letter to the Editor

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