Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia
VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy
Article Figures & Tables
Figures
- FIG. 1.
Supplementation with vitamins C+E significantly inhibited acellular capillaries in diabetic rats and tended to inhibit formation of pericyte ghosts but had no effect on any lesions in experimentally galactosemic rats. Each bar represents mean ± SD of 7–10 rats. *P < 0.05 vs. normal controls; **P < 0.05 vs. respective untreated diabetic rats or untreated galactose-fed rats.
- FIG. 2.
Administration of multi-antioxidant mixture significantly inhibited the development of both acellular capillaries and pericyte ghosts in retinas of diabetic rats and experimentally galactosemic rats. Each bar represents the mean ± SD of 7–9 rats. *P < 0.05 vs. normal; **P < 0.05 vs. respective untreated diabetic rats or untreated galactose-fed rats.
Tables
- TABLE 1
Administration of multi-antioxidants inhibited hyperglycemia-induced elevation in retinal TBARS, NO, and PKC
TBARS (pmol/mg protein) NO (% normal) PKC (pmol Pi · min−1 · mg−1 protein) Normal 159 ± 17 100 ± 22 16.5 ± 1.9 Diabetes 297 ± 23* 165 ± 15* 22.7 ± 2.9* Diabetes + multi-antiox 179 ± 21† 114 ± 29† 17.3 ± 2.4† Galactose 296 ± 23* 140 ± 7* 21.6 ± 2.1* Galactose + multi-antiox 200 ± 12† 111 ± 10† 16.3 ± 0.7† Values are mean ± SD of 6–9 rats in each group. Multi-antiox, multi-antioxidant supplements;
- *
* P < 0.05 vs. normal rats.
- †
† P < 0.05 vs. respective untreated diabetic rats or untreated galactose-fed rats.
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