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Epidemiology

Predictability of Childhood Adiposity and Insulin for Developing Insulin Resistance Syndrome (Syndrome X) in Young Adulthood

The Bogalusa Heart Study

  1. Sathanur R. Srinivasan12,
  2. Leann Myers3 and
  3. Gerald S. Berenson12
  1. 1Tulane Center for Cardiovascular Health, Departments of
  2. 2Epidemiology and
  3. 3Biostatistics, Tulane University Health Sciences Center, New Orleans, Louisiana
    Diabetes 2002 Jan; 51(1): 204-209. https://doi.org/10.2337/diabetes.51.1.204
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    The Bogalusa Heart Study

    Abstract

    The occurrence of insulin resistance syndrome (syndrome X) is common in the general population. However, information is scant on the childhood predictors of syndrome X. This study examined the relative contribution of childhood adiposity and insulin to the adulthood risk of developing syndrome X in a biracial (black-white) community-based longitudinal cohort (n = 745; baseline age, 8–17 years; mean ± SD follow-up period, 11.6 ± 3.4 years). The four criterion risk variables considered were the highest quartile (specific for age, race, sex, and study year) of 1) BMI, 2) fasting insulin, 3) systolic or mean arterial blood pressure, and 4) total cholesterol to HDL cholesterol ratio or triglycerides to HDL cholesterol ratio. Clustering was defined as the combination of all four risk variables. In addition to the criterion risk variables, clustered adults had adverse levels of total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, diastolic blood pressure, and glucose compared with those who did not cluster (P < 0.001). Childhood variables, except glucose, showed adverse trends with increasing number of criterion risk variables present in adulthood (P for trend, 0.01–0.0001). The proportion of individuals who developed clustering as adults increased across childhood BMI (P for trend <0.0001) and insulin (P for trend <0.01) quartiles. The relationship to childhood BMI remained significant even after adjusting for childhood insulin. In contrast, corresponding association with childhood insulin disappeared after adjusting for childhood BMI. In a logistic regression model, childhood BMI and insulin were significant predictors of adulthood clustering, with BMI being the strongest and showing a curvilinear relationship. Using an insulin resistance index instead of insulin did not change the above findings. These results indicate that childhood obesity is a powerful predictor of development of syndrome X and underscore the importance of weight control early in life.

    Footnotes

    • Address correspondence and reprint requests to Gerald S. Berenson, Tulane Center for Cardiovascular Health, 1440 Canal Street, Suite 2140, New Orleans, LA 70112. E-mail: berenson{at}tulane.edu.

      Received for publication 28 February 2001 and accepted in revised form 12 October 2001.

      CDC, Centers for Disease Control and Prevention.

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    Predictability of Childhood Adiposity and Insulin for Developing Insulin Resistance Syndrome (Syndrome X) in Young Adulthood
    Sathanur R. Srinivasan, Leann Myers, Gerald S. Berenson
    Diabetes Jan 2002, 51 (1) 204-209; DOI: 10.2337/diabetes.51.1.204

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    Predictability of Childhood Adiposity and Insulin for Developing Insulin Resistance Syndrome (Syndrome X) in Young Adulthood
    Sathanur R. Srinivasan, Leann Myers, Gerald S. Berenson
    Diabetes Jan 2002, 51 (1) 204-209; DOI: 10.2337/diabetes.51.1.204
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