High Familial Risk and Genetic Susceptibility in Early Onset Childhood Diabetes
Article Figures & Tables
Figures
- FIG. 1.
The cumulative risk of diabetes in siblings (A) and parents (B) subdivided according to the age at diagnosis of the proband.
Tables
- TABLE 1
Subject characteristics
Siblings Parents Nondiabetic n 1,377 2,313 Age at time of analysis 16.8 (0.23–40) 44 (23–94) Male:female 656:721 1,092:1,221 Type 1 diabetes n 53 106 Age at diagnosis 6.7 (0.5–17) 21 (1–56) Male:female 24:29 70:36 Diabetes on study entry 27 91 Diabetes onset during follow-up 26 15 -
Data are n and median (range).
-
- TABLE 2
The prevalence of IAAs greater than or equal to the 97.5th percentile of schoolchildren control subjects in unaffected siblings and parents
Antibody markers Age at diagnosis of the proband <5 years 5–9 years 10–14 years Siblings n 178 368 623 None 141 (79) 332 (90) 537 (86) 1 24 (13) 28 (8) 71 (11) 2 4 (2.2) 5 (1.4) 6 (1.0) 3 7 (3.9) 1 (0.3) 6 (1.0) 4 2 (1.1) 2 (0.5) 3 (0.5) Parents n 515 702 913 None 456 (89) 631 (89) 815 (89) 1 48 (9) 60 (9) 81 (9) 2 4 (0.8) 6 (0.9) 13 (1.4) 3 7 (1.4) 4 (0.6) 3 (0.3) 4 1 (0.1) 1 (0.1) -
Data are n (%).
-
- TABLE 3
Genotyping results
DRB1-DQA1-DQB1 Age at diagnosis of the proband <5 years 5–9 years 10–14 years n 157 201 215 03-0501-02/04-0301-0302 81 (52) 64 (32) 72 (33) 04-0301-0302/04-0301-0302 12 (8) 20 (10) 14 (7) 04-0301-0302/X 30 (19) 51 (25) 56 (26) 03-0501-02/03-0501-02 8 (5) 18 (9) 26 (12) 03-0501-02/X 22 (14) 38 (19) 40 (19) X/X 4 (2) 10 (5) 7 (3) -
Data are n (%).
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In this Issue
January 2002, 51(1)
High Familial Risk and Genetic Susceptibility in Early Onset Childhood Diabetes
