Amelioration of Long-Term Renal Changes in Obese Type 2 Diabetic Mice by a Neutralizing Vascular Endothelial Growth Factor Antibody
Article Figures & Tables
Figures
- FIG. 1.
Mean right kidney weight and glomerular volume on day 60 in nondiabetic controls (□), placebo-treated diabetic db/db mice (▪), and VEGF antibody-treated diabetic db/db mice ([cjs2108]). Values are means + SE (n = 6–12 in each group). *P < 0.01 vs. nondiabetic controls; ΔP < 0.05 vs. nondiabetic controls and placebo-treated db/db mice.
- FIG. 2.
BMT and total mesangial volume on day 60 in nondiabetic controls (□), placebo-treated diabetic db/db mice (▪), and VEGF antibody-treated diabetic db/db mice ([cjs2108]). Values are means + SE (n = 6–12 in each group). *P < 0.05 vs. nondiabetic controls and VEGF antibody-treated diabetic db/db mice.
- FIG. 3.
Mean 24-h UAE and CrCl on day 60 in nondiabetic controls (□), placebo-treated diabetic db/db mice (▪), and VEGF antibody-treated diabetic db/db mice ([cjs2108]). Values are means + SE (n = 6–12 in each group). *P < 0.01 vs. nondiabetic controls; ΔP < 0.05 vs. nondiabetic controls and placebo-treated db/db mice.
Tables
- TABLE 1
Mean body weight, blood glucose, and food consumption at day 0 and 60 in placebo-treated controls, placebo-treated diabetic db/db mice, and VEGF antibody-treated diabetic db/db mice
Day 0 Day 60 Body weight (g) Blood glucose (mmol/l) Food consumption (g/24 h) Body weight (g) Blood glucose (mmol/l) Food consumption (g/24 h) Control, placebo 19.6 ± 0.4 5.4 ± 0.3 5.5 ± 0.6 21.3 ± 0.2 5.5 ± 0.3 5.9 ± 0.8 Diabetic, placebo 41.4 ± 0.7* 18.6 ± 1.0* 8.5 ± 0.7* 47.3 ± 1.0* 19.8 ± 1.4* 9.1 ± 1.1* Diabetic, VEGF antibody 40.6 ± 0.8* 18.4 ± 1.0* 8.8 ± 0.8* 46.2 ± 0.9* 18.8 ± 2.0* 8.9 ± 0.9* Data are means ± SE (n = 6–12 in each group).
- *
* P < 0.01 vs. nondiabetic controls.
- TABLE 2
Mean serum insulin, liver weight, and heart weight at day 60 in placebo-treated controls, placebo-treated diabetic db/db mice, and VEGF antibody-treated diabetic db/db mice
Day 60 Serum insulin (μg/l) Liver weight (mg) Heart weight (mg) Control, placebo 2.86 ± 0.29 1,136 ± 36 103 ± 4 Diabetic, placebo 18.82 ± 1.60* 2,272 ± 88* 109 ± 3 Diabetic, VEGF antibody 16.85 ± 1.67* 1,891 ± 65† 103 ± 3 Data are means ± SE (n = 6–12 in each group).
- *
* P < 0.01 vs. nondiabetic controls;
- †
† P < 0.05 vs. the two other groups.
In this Issue
