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Complications

Morphometry of Dorsal Root Ganglion in Chronic Experimental Diabetic Neuropathy

  1. Motoko Kishi,
  2. James Tanabe,
  3. James D. Schmelzer and
  4. Phillip A. Low
  1. From the Department of Neurology, Mayo Clinic, Rochester, Minnesota
    Diabetes 2002 Mar; 51(3): 819-824. https://doi.org/10.2337/diabetes.51.3.819
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    • FIG. 1.
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      FIG. 1.

      Dorsal root ganglion neurons of control (A) and diabetic (B) rats. Diabetic neurons tend to be small and more basophilic and have more and larger vacuoles and pigmentary inclusions. Bar represents 25 μm.

    • FIG. 2.
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      FIG. 2.

      Composite histogram of L5 dorsal root ganglia of control and diabetic rats.

    • FIG. 3.
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      FIG. 3.

      Diameter histograms of control and diabetic ganglia for all neurons (A) and two groups of large neurons (B). *P < 0.05; **P < 0.01.

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    • TABLE 1

      Electrophysiology of 12-month diabetic and age-matched control rats

      GroupnDigital nerve
      Sciatic-tibial nerve
      Caudal NAP
      Caudal CMAP
      CV (m/s)Amplitude (μV)CV (m/s)Amplitude (mV)CV (m/s)Amplitude (μV)CV (m/s)Amplitude (mV)
      Control946.3 ± 2.123.3 ± 2.649.5 ± 1.63.9 ± 1.160 ± 1.5101 ± 746 ± 0.54.9 ± 0.3
      Diabetic940.6 ± 1.730.9 ± 2.746.3 ± 1.05.2 ± 1.247 ± 1.2103 ± 841.3 ± 0.25.8 ± 0.9
      P0.04970.05900.11760.44050.00000.85570.03390.3818
      • Data are means ± SE. CMAP, compound muscle action potential; CV, conduction velocity; NAP, nerve action potential.

    • TABLE 2

      Morphometric data on L5 DRGs from control and diabetic rats

      Identification numberNumber of cells
      % Small% LargeRatio of large to small
      TotalSmallLarge
      Control
       671L17,88813,3054,58374260.344
       672L16,42512,5193,90676240.312
       675L17,70013,2404,46075250.337
       676L12,0337,8114,22165350.540
       677L14,6309,5295,10165350.535
       678L13,1468,9114,23568320.475
       Mean ± SE15,304 ± 99110,886 ± 9884,418 ± 16671 ± 229 ± 20.424 ± 0.043
      Diabetic
       664L11,5879,0102,57778220.286
       665L13,93710,5903,34876240.316
       667L18,60015,2883,31282180.217
       680L20,21816,3433,87581190.237
       681L12,87010,4422,42881190.233
       682L17,53112,9994,53274260.349
       683L9,1886,6612,52772280.379
       Mean ± SE14,847 ± 1,52411,619 ± 1,3053,229 ± 29778 ± 122 ± 10.288 ± 0.024
      • Data are means ± SE. Differences (t test) for number of total cells and small cells were not significant (P = 0.814 and 0.672, respectively); differences were significant for number of large cells (P = 0.007), % small (P = 0.014), % large (P = 0.014), and the ratio of large to small (P = 0.015).

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    Morphometry of Dorsal Root Ganglion in Chronic Experimental Diabetic Neuropathy
    Motoko Kishi, James Tanabe, James D. Schmelzer, Phillip A. Low
    Diabetes Mar 2002, 51 (3) 819-824; DOI: 10.2337/diabetes.51.3.819

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    Morphometry of Dorsal Root Ganglion in Chronic Experimental Diabetic Neuropathy
    Motoko Kishi, James Tanabe, James D. Schmelzer, Phillip A. Low
    Diabetes Mar 2002, 51 (3) 819-824; DOI: 10.2337/diabetes.51.3.819
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