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Pathophysiology

Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat

  1. Antonio Ceriello1,
  2. Lisa Quagliaro2,
  3. Michele D’Amico3,
  4. Clara Di Filippo3,
  5. Raffaele Marfella4,
  6. Francesco Nappo4,
  7. Liberato Berrino3,
  8. Francesco Rossi3 and
  9. Dario Giugliano4
  1. 1Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
  2. 2Morpurgo-Hofmann Research Laboratory on Aging, Udine, Italy
  3. 3Department of Experimental Medicine, Sezione di Farmacologia L. Donatelli, Second University of Naples, Naples, Italy
  4. 4Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes 2002 Apr; 51(4): 1076-1082. https://doi.org/10.2337/diabetes.51.4.1076
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    • FIG. 1.
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      FIG. 1.

      Coronary perfusion pressure after 2 h infusion with control (11.1 mmol/l d-glucose), high glucose (33.3 mmol/l d-glucose), high glucose plus glutathione (33.3 mmol/l d-glucose plus 0.3 mmol/l glutathione), and osmotic (11.1 mmol/l d-glucose plus 22.2 mmol/l mannitol) solutions. GSH, glutathione.

    • FIG. 2.
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      FIG. 2.

      Nitrotyrosine immmunostaining in heart perfused with control solution (A), high glucose (B), and high glucose plus glutathione (C); negative control (D).

    • FIG. 3.
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      FIG. 3.

      iNOS immunostaining in heart perfused with control solution (A), high glucose (B), and high glucose plus glutathione (C).

    • FIG. 4.
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      FIG. 4.

      Western blot of iNOS in heart perfused with control solution (lane 1), high glucose (lane 2), and high glucose plus glutathione (lane 3).

    • FIG. 5.
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      FIG. 5.

      mRNA of iNOS evaluated by RT-PCR in heart perfused with control solution (lane 1), high glucose (lane 2), and high glucose plus glutathione (lane 3).

    • FIG. 6.
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      FIG. 6.

      NO and superoxide production during 2 h infusion in heart perfused with control solution, high glucose and high glucose plus glutathione. GSH, glutathione.

    • FIG. 7.
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      FIG. 7.

      Apoptosis detected in tissue from heart perfused with control solution (A), high glucose (B), and high glucose plus glutathione (C).

    • FIG. 8.
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      FIG. 8.

      Apoptosis detected by Western blot for caspase 3 (Casp3a) in tissue from heart perfused with control solution (lane 1), high glucose plus glutathione (lane 2), and high glucose (lane 3).

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    April 2002, 51(4)
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    Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat
    Antonio Ceriello, Lisa Quagliaro, Michele D’Amico, Clara Di Filippo, Raffaele Marfella, Francesco Nappo, Liberato Berrino, Francesco Rossi, Dario Giugliano
    Diabetes Apr 2002, 51 (4) 1076-1082; DOI: 10.2337/diabetes.51.4.1076

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    Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat
    Antonio Ceriello, Lisa Quagliaro, Michele D’Amico, Clara Di Filippo, Raffaele Marfella, Francesco Nappo, Liberato Berrino, Francesco Rossi, Dario Giugliano
    Diabetes Apr 2002, 51 (4) 1076-1082; DOI: 10.2337/diabetes.51.4.1076
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