Skip to main content
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • Log out
  • My Cart
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Diabetes
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Perspectives in Diabetes

The Ryanodine Receptor Calcium Channel of β-Cells

Molecular Regulation and Physiological Significance

  1. Md. Shahidul Islam
  1. From the Department of Molecular Medicine, Karolinska Institutet, Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
    Diabetes 2002 May; 51(5): 1299-1309. https://doi.org/10.2337/diabetes.51.5.1299
    PreviousNext
    • Article
    • Figures & Tables
    • Info & Metrics
    • PDF
    Loading

    Molecular Regulation and Physiological Significance

    Abstract

    The list of Ca2+ channels involved in stimulus-secretion coupling in β-cells is increasing. In this respect the roles of the voltage-gated Ca2+ channels and IP3 receptors are well accepted. There is a lack of consensus about the significance of a third group of Ca2+ channels called ryanodine (RY) receptors. These are large conduits located on Ca2+ storage organelle. Ca2+ gates these channels in a concentration- and time-dependent manner. Activation of these channels by Ca2+ leads to fast release of Ca2+ from the stores, a process called Ca2+-induced Ca2+ release (CICR). A substantial body of evidence confirms that β-cells have RY receptors. CICR by RY receptors amplifies Ca2+ signals. Some properties of RY receptors ensure that this amplification process is engaged in a context-dependent manner. Several endogenous molecules and processes that modulate RY receptors determine the appropriate context. Among these are several glycolytic intermediates, long-chain acyl CoA, ATP, cAMP, cADPR, NO, and high luminal Ca2+ concentration, and all of these have been shown to sensitize RY receptors to the trigger action of Ca2+. RY receptors, thus, detect co-incident signals and integrate them. These Ca2+ channels are targets for the action of cAMP-linked incretin hormones that stimulate glucose-dependent insulin secretion. In β-cells some RY receptors are located on the secretory vesicles. Thus, despite their low abundance, RY receptors are emerging as distinct players in β-cell function by virtue of their large conductance, strategic locations, and their ability to amplify Ca2+ signals in a context-dependent manner.

    Footnotes

    • Address correspondence and reprint requests to Md. Shahidul Islam, Associate Professor, Department of Molecular Medicine, Karolinska Institutet, Department of Endocrinology, Karolinska Hospital L1:02, S-171 76 Stockholm, Sweden. E-mail: shahidul.islam{at}molmed.ki.se.

      Received for publication 6 November 2001 and accepted in revised form 14 January 2002.

      [Ca2+]c, cytosolic free Ca2+ concentration; [Ca2+]m, mitochondrial Ca2+ concentration; CICR, Ca2+-induced Ca2+ release; ER, endoplasmic reticulum; FDP, fructose 1,6-diphosphate; KATP, ATP-sensitive potassium channel; IBMX, 3-isobutyl-1-methylxanthine; IP3R, IP3 receptor; NO, nitric oxide; PDE, phosphodiesterase; PKA, protein kinase A; RY, ryanodine.

    • DIABETES
    View Full Text
    PreviousNext
    Back to top

    In this Issue

    May 2002, 51(5)
    • Table of Contents
    • Index by Author
    Sign up to receive current issue alerts
    View Selected Citations (0)
    Print
    Download PDF
    Article Alerts
    Sign In to Email Alerts with your Email Address
    Email Article

    Thank you for your interest in spreading the word about Diabetes.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    The Ryanodine Receptor Calcium Channel of β-Cells
    (Your Name) has forwarded a page to you from Diabetes
    (Your Name) thought you would like to see this page from the Diabetes web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    The Ryanodine Receptor Calcium Channel of β-Cells
    Md. Shahidul Islam
    Diabetes May 2002, 51 (5) 1299-1309; DOI: 10.2337/diabetes.51.5.1299

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Add to Selected Citations
    Share

    The Ryanodine Receptor Calcium Channel of β-Cells
    Md. Shahidul Islam
    Diabetes May 2002, 51 (5) 1299-1309; DOI: 10.2337/diabetes.51.5.1299
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Jump to section

    • Article
      • Abstract
      • INTRACELLULAR CALCIUM CHANNELS OF β-CELLS.
      • STRUCTURES AND PROPERTIES OF RY RECEPTORS
      • RY RECEPTOR PHARMACOLOGY
      • REGULATION OF RY RECEPTORS BY SECOND MESSENGERS
      • REGULATION OF RY RECEPTORS BY SIGNALS GENERATED FROM GLUCOSE METABOLISM
      • ROLE OF RY RECEPTORS IN MITOCHONDRIAL Ca2+ SIGNALING
      • ROLE OF RY RECEPTORS IN GLUCOSE-STIMULATED INSULIN SECRETION
      • PHYSIOLOGICAL ROLES OF RY RECEPTORS IN GLUCOSE-INDUCED STIMULUS-SECRETION COUPLING
      • STUDIES ON KNOCKOUT MICE
      • RELEVANCE TO DIABETES
      • CONCLUSION
      • Acknowledgments
      • Footnotes
      • REFERENCES
    • Figures & Tables
    • Info & Metrics
    • PDF

    Related Articles

    Cited By...

    More in this TOC Section

    • Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors
    • Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes
    • Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders
    Show more Perspectives in Diabetes

    Similar Articles

    Navigate

    • Current Issue
    • Online Ahead of Print
    • Scientific Sessions Abstracts
    • Collections
    • Archives
    • Submit
    • Subscribe
    • Email Alerts
    • RSS Feeds

    More Information

    • About the Journal
    • Instructions for Authors
    • Journal Policies
    • Reprints and Permissions
    • Advertising
    • Privacy Policy: ADA Journals
    • Copyright Notice/Public Access Policy
    • Contact Us

    Other ADA Resources

    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • Scientific Sessions Abstracts
    • Standards of Medical Care in Diabetes
    • BMJ Open - Diabetes Research & Care
    • Professional Books
    • Diabetes Forecast

     

    • DiabetesJournals.org
    • Diabetes Core Update
    • ADA's DiabetesPro
    • ADA Member Directory
    • Diabetes.org

    © 2021 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.