Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated

Roberto Lupi; Francesco Dotta; Lorella Marselli; Silvia Del Guerra; Matilde Masini; Carmela Santangelo; Giovanni Patané; Ugo Boggi; Salvatore Piro; Marcello Anello; Ettore Bergamini; Franco Mosca; Umberto Di Mario; Stefano Del Prato; Piero Marchetti

doi:10.2337/diabetes.51.5.1437

Islet Studies

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets

Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated

Roberto Lupi1,
Francesco Dotta2,
Lorella Marselli1,
Silvia Del Guerra1,
Matilde Masini1,
Carmela Santangelo2,
Giovanni Patané3,
Ugo Boggi4,
Salvatore Piro3,
Marcello Anello3,
Ettore Bergamini1,
Franco Mosca4,
Umberto Di Mario2,
Stefano Del Prato1 and
Piero Marchetti1

¹Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
²Department of Clinical Sciences-Endocrinology, “La Sapienza” University, Rome, Italy
³Department of Endocrinology, University of Catania, Catania, Italy
⁴Department of Oncology, University of Pisa, Pisa, Italy

Diabetes 2002 May; 51(5): 1437-1442. https://doi.org/10.2337/diabetes.51.5.1437

Article Information

vol. 51 no. 5 1437-1442

DOI

https://doi.org/10.2337/diabetes.51.5.1437

PubMed

11978640

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Published in print May 1, 2002.

DIABETES

Author Information

Roberto Lupi1,
Francesco Dotta2,
Lorella Marselli1,
Silvia Del Guerra1,
Matilde Masini1,
Carmela Santangelo2,
Giovanni Patané3,
Ugo Boggi4,
Salvatore Piro3,
Marcello Anello3,
Ettore Bergamini1,
Franco Mosca4,
Umberto Di Mario2,
Stefano Del Prato1 and
Piero Marchetti1

¹Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
²Department of Clinical Sciences-Endocrinology, “La Sapienza” University, Rome, Italy
³Department of Endocrinology, University of Catania, Catania, Italy
⁴Department of Oncology, University of Pisa, Pisa, Italy

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