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Table of Contents

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July 01 2002; volume 51 issue 7

Rapid Publication

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    Functional Genomics of the Endocrine PancreasThe Pancreas Clone Set and PancChip, New Resources for Diabetes Research
    L. Marie Scearce, John E. Brestelli, Shannon K. McWeeney, Catherine S. Lee, Joan Mazzarelli, Deborah F. Pinney, Angel Pizarro, Christian J. Stoeckert, Sandra W. Clifton, M. Alan Permutt, Juliana Brown, Douglas A. Melton and Klaus H. Kaestner
    Diabetes 2002 Jul; 51 (7): 1997-2004. https://doi.org/10.2337/diabetes.51.7.1997
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    Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
    Samar I. Itani, Neil B. Ruderman, Frank Schmieder and Guenther Boden
    Diabetes 2002 Jul; 51 (7): 2005-2011. https://doi.org/10.2337/diabetes.51.7.2005
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    The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man
    Evelyne Marion, Pamela Jane Kaisaki, Valérie Pouillon, Cyril Gueydan, Jonathan C. Levy, André Bodson, Georges Krzentowski, Jean-Claude Daubresse, Jean Mockel, Jens Behrends, Geneviève Servais, Claude Szpirer, Véronique Kruys, Dominique Gauguier and Stéphane Schurmans
    Diabetes 2002 Jul; 51 (7): 2012-2017. https://doi.org/10.2337/diabetes.51.7.2012
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    Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release
    Daisy Flamez, Veerle Berger, Mogens Kruhøffer, Torben Orntoft, Daniel Pipeleers and Frans C. Schuit
    Diabetes 2002 Jul; 51 (7): 2018-2024. https://doi.org/10.2337/diabetes.51.7.2018
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Perspectives in Diabetes

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    Renal Perfusion and the Renal Hemodynamic Response to Blocking the Renin System in DiabetesAre the Forces Leading to Vasodilation and Vasoconstriction Linked?
    M. Cecilia Lansang and Norman K. Hollenberg
    Diabetes 2002 Jul; 51 (7): 2025-2028. https://doi.org/10.2337/diabetes.51.7.2025
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Metabolism and Signal Transduction

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    Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes
    Vanessa van Harmelen, Andrea Dicker, Mikael Rydén, Hans Hauner, Fredrik Lönnqvist, Erik Näslund and Peter Arner
    Diabetes 2002 Jul; 51 (7): 2029-2036. https://doi.org/10.2337/diabetes.51.7.2029
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    Isomer-Dependent Metabolic Effects of Conjugated Linoleic AcidInsights From Molecular Markers Sterol Regulatory Element-Binding Protein-1c and LXRα
    Helen M. Roche, Enda Noone, Ciaran Sewter, Siobhan Mc Bennett, David Savage, Michael J. Gibney, Stephen O’Rahilly and Antonio J. Vidal-Puig
    Diabetes 2002 Jul; 51 (7): 2037-2044. https://doi.org/10.2337/diabetes.51.7.2037
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    Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes
    Yoshikazu Tamori, Jiro Masugi, Naonobu Nishino and Masato Kasuga
    Diabetes 2002 Jul; 51 (7): 2045-2055. https://doi.org/10.2337/diabetes.51.7.2045
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    Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central Neurons
    Ambrose A. Dunn-Meynell, Vanessa H. Routh, Ling Kang, Larry Gaspers and Barry E. Levin
    Diabetes 2002 Jul; 51 (7): 2056-2065. https://doi.org/10.2337/diabetes.51.7.2056
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    Normalization of Skeletal Muscle Glycogen Synthesis and Glycolysis in Rosiglitazone-Treated Zucker Fatty RatsAn In Vivo Nuclear Magnetic Resonance Study
    Beat M. Jucker, Thomas R. Schaeffer, Robin E. Haimbach, Thomas S. McIntosh, Daniel Chun, Matthew Mayer, Derek H. Ohlstein, Hugh M. Davis, Stephen A. Smith, Alexander R. Cobitz and Susanta K. Sarkar
    Diabetes 2002 Jul; 51 (7): 2066-2073. https://doi.org/10.2337/diabetes.51.7.2066
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    Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes
    Nicolas Musi, Michael F. Hirshman, Jonas Nygren, Monika Svanfeldt, Peter Bavenholm, Olav Rooyackers, Gaochao Zhou, Joanne M. Williamson, Olle Ljunqvist, Suad Efendic, David E. Moller, Anders Thorell and Laurie J. Goodyear
    Diabetes 2002 Jul; 51 (7): 2074-2081. https://doi.org/10.2337/diabetes.51.7.2074
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    Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse
    Susanna M. Hofmann, Heng-Jiang Dong, Zhu Li, Weijing Cai, Jennifer Altomonte, Swan N. Thung, Feng Zeng, Edward A. Fisher and Helen Vlassara
    Diabetes 2002 Jul; 51 (7): 2082-2089. https://doi.org/10.2337/diabetes.51.7.2082
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    Sustained Exposure of L6 Myotubes to High Glucose and Insulin Decreases Insulin-Stimulated GLUT4 Translocation but Upregulates GLUT4 Activity
    Carol Huang, Romel Somwar, Nish Patel, Wenyan Niu, Dóra Török and Amira Klip
    Diabetes 2002 Jul; 51 (7): 2090-2098. https://doi.org/10.2337/diabetes.51.7.2090
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Obesity Studies

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    Appetite Suppression and Weight Reduction by a Centrally Active Aminosterol
    Rexford S. Ahima, Hiralben R. Patel, Nobuhiko Takahashi, Yong Qi, Stanley M. Hileman and Michael A. Zasloff
    Diabetes 2002 Jul; 51 (7): 2099-2104. https://doi.org/10.2337/diabetes.51.7.2099
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    Regulation of Circulating Soluble Leptin Receptor Levels By Gender, Adiposity, Sex Steroids, and LeptinObservational and Interventional Studies in Humans
    Jean L. Chan, Susann Blüher, Nikos Yiannakouris, Marc A. Suchard, Jurgen Kratzsch and Christos S. Mantzoros
    Diabetes 2002 Jul; 51 (7): 2105-2112. https://doi.org/10.2337/diabetes.51.7.2105
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    Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity
    Martin Haluzik, Kelly R. Dietz, Jason K. Kim, Bernice Marcus-Samuels, Gerald I. Shulman, Oksana Gavrilova and Marc L. Reitman
    Diabetes 2002 Jul; 51 (7): 2113-2118. https://doi.org/10.2337/diabetes.51.7.2113
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Immunology and Transplantation

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    Redirection of Human Autoreactive T-Cells Upon Interaction With Dendritic Cells Modulated by TX527, an Analog of 1,25 Dihydroxyvitamin D3
    Astrid G.S. van Halteren, Evelyne van Etten, Esther C. de Jong, Roger Bouillon, Bart O. Roep and Chantal Mathieu
    Diabetes 2002 Jul; 51 (7): 2119-2125. https://doi.org/10.2337/diabetes.51.7.2119
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    Immunological Characterization and Therapeutic Activity of an Altered-Peptide Ligand, NBI-6024, Based on the Immunodominant Type 1 Diabetes Autoantigen Insulin B-Chain (9–23) Peptide
    David G. Alleva, Amitabh Gaur, Liping Jin, Dale Wegmann, Peter A. Gottlieb, Anil Pahuja, Eric B. Johnson, Theresa Motheral, Amy Putnam, Paul D. Crowe, Nicholas Ling, Stefen A. Boehme and Paul J. Conlon
    Diabetes 2002 Jul; 51 (7): 2126-2134. https://doi.org/10.2337/diabetes.51.7.2126
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    Pancreatic Islet Transplantation Using the Nonhuman Primate (Rhesus) Model Predicts That the Portal Vein Is Superior to the Celiac Artery as the Islet Infusion Site
    Boaz Hirshberg, Sean Montgomery, Michael G. Wysoki, He Xu, Doug Tadaki, Janet Lee, Kenneth Hines, Jason Gaglia, Noelle Patterson, John Leconte, Douglas Hale, Richard Chang, Alan D. Kirk and David M. Harlan
    Diabetes 2002 Jul; 51 (7): 2135-2140. https://doi.org/10.2337/diabetes.51.7.2135
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    An Interval Tightly Linked to but Distinct From the H2 Complex Controls Both Overt Diabetes (Idd16) and Chronic Experimental Autoimmune Thyroiditis (Ceat1) in Nonobese Diabetic Mice
    Olivier Boulard, Diane Damotte, Nathalie Deruytter, Guy Fluteau, Claude Carnaud and Henri-Jean Garchon
    Diabetes 2002 Jul; 51 (7): 2141-2147. https://doi.org/10.2337/diabetes.51.7.2141
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Islet Studies

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    Successful Islet TransplantationContinued Insulin Reserve Provides Long-Term Glycemic Control
    Edmond A. Ryan, Jonathan R.T. Lakey, Breay W. Paty, Sharleen Imes, Gregory S. Korbutt, Norman M. Kneteman, David Bigam, Ray V. Rajotte and A.M. James Shapiro
    Diabetes 2002 Jul; 51 (7): 2148-2157. https://doi.org/10.2337/diabetes.51.7.2148
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    Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide
    John G. Geisler, Walter Zawalich, Kathleen Zawalich, Jonathan R.T. Lakey, Hans Stukenbrok, Anthony J. Milici and Walter C. Soeller
    Diabetes 2002 Jul; 51 (7): 2158-2169. https://doi.org/10.2337/diabetes.51.7.2158
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Pathophysiology

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    β-Cell Function Is a Major Contributor to Oral Glucose Tolerance in High-Risk Relatives of Four Ethnic Groups in the U.S.
    Christine C. Jensen, Miriam Cnop, Rebecca L. Hull, Wilfred Y. Fujimoto, Steven E. Kahn and the American Diabetes Association GENNID Study Group
    Diabetes 2002 Jul; 51 (7): 2170-2178. https://doi.org/10.2337/diabetes.51.7.2170
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    Glycemic Control Determines Hepatic and Peripheral Glucose Effectiveness in Type 2 Diabetic Subjects
    Meredith Hawkins, Ilan Gabriely, Robert Wozniak, Kalpana Reddy, Luciano Rossetti and Harry Shamoon
    Diabetes 2002 Jul; 51 (7): 2179-2189. https://doi.org/10.2337/diabetes.51.7.2179
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    Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle
    Svetlana E. Nikoulina, Theodore P. Ciaraldi, Sunder Mudaliar, Leslie Carter, Kirk Johnson and Robert R. Henry
    Diabetes 2002 Jul; 51 (7): 2190-2198. https://doi.org/10.2337/diabetes.51.7.2190
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    Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome
    Esben S. Buhl, Niels Jessen, Rasmus Pold, Thomas Ledet, Allan Flyvbjerg, Steen B. Pedersen, Oluf Pedersen, Ole Schmitz and Sten Lund
    Diabetes 2002 Jul; 51 (7): 2199-2206. https://doi.org/10.2337/diabetes.51.7.2199
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    TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
    John P. Kirwan, Sylvie Hauguel-De Mouzon, Jacques Lepercq, Jean-Claude Challier, Larraine Huston-Presley, Jacob E. Friedman, Satish C. Kalhan and Patrick M. Catalano
    Diabetes 2002 Jul; 51 (7): 2207-2213. https://doi.org/10.2337/diabetes.51.7.2207
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    Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes
    Thomas Jansson, Ylva Ekstrand, Caroline Björn, Margareta Wennergren and Theresa L. Powell
    Diabetes 2002 Jul; 51 (7): 2214-2219. https://doi.org/10.2337/diabetes.51.7.2214
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    The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression
    Patrick Schrauwen, Dorien P.C. van Aggel-Leijssen, Gabby Hul, Anton J.M. Wagenmakers, Hubert Vidal, Wim H.M. Saris and Marleen A. van Baak
    Diabetes 2002 Jul; 51 (7): 2220-2226. https://doi.org/10.2337/diabetes.51.7.2220
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Complications

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    Herpes Simplex-Mediated Gene Transfer of Nerve Growth Factor Protects Against Peripheral Neuropathy in Streptozotocin-Induced Diabetes in the Mouse
    James R. Goss, William F. Goins, David Lacomis, Marina Mata, Joseph C. Glorioso and David J. Fink
    Diabetes 2002 Jul; 51 (7): 2227-2232. https://doi.org/10.2337/diabetes.51.7.2227
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    Influence of Experimental Diabetes on the Microcirculation of Injured Peripheral NerveFunctional and Morphological Aspects
    James M. Kennedy and Douglas W. Zochodne
    Diabetes 2002 Jul; 51 (7): 2233-2240. https://doi.org/10.2337/diabetes.51.7.2233
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    Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes
    Giulio Romeo, Wei-Hua Liu, Veronica Asnaghi, Timothy S. Kern and Mara Lorenzi
    Diabetes 2002 Jul; 51 (7): 2241-2248. https://doi.org/10.2337/diabetes.51.7.2241
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    Elevated Spinal Cyclooxygenase and Prostaglandin Release During Hyperalgesia in Diabetic Rats
    Jason D. Freshwater, Camilla I. Svensson, Annika B. Malmberg and Nigel A. Calcutt
    Diabetes 2002 Jul; 51 (7): 2249-2255. https://doi.org/10.2337/diabetes.51.7.2249
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    Negative Regulation of Rho Signaling by Insulin and Its Impact on Actin Cytoskeleton Organization in Vascular Smooth Muscle CellsRole of Nitric Oxide and Cyclic Guanosine Monophosphate Signaling Pathways
    Najma Begum, Oana A. Sandu and Noreen Duddy
    Diabetes 2002 Jul; 51 (7): 2256-2263. https://doi.org/10.2337/diabetes.51.7.2256
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    Minor Effect of GLUT1 Polymorphisms on Susceptibility to Diabetic Nephropathy in Type 1 Diabetes
    Daniel P.K. Ng, Luis Canani, Shin-ichi Araki, Adam Smiles, Dariusz Moczulski, James H. Warram and Andrzej S. Krolewski
    Diabetes 2002 Jul; 51 (7): 2264-2269. https://doi.org/10.2337/diabetes.51.7.2264
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    Modulation of Growth Hormone Signal Transduction in Kidneys of Streptozotocin-Induced Diabetic AnimalsEffect of a Growth Hormone Receptor Antagonist
    Ana C.P. Thirone, John A. Scarlett, Alessandra L. Gasparetti, Eliana P. Araujo, Maria H.L. Lima, Carla R.O. Carvalho, Lício A. Velloso and Mario J.A. Saad
    Diabetes 2002 Jul; 51 (7): 2270-2281. https://doi.org/10.2337/diabetes.51.7.2270
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    Endothelial Dysfunction Relates to Folate Status in Children and Adolescents With Type 1 Diabetes
    Esko J. Wiltshire, Roger Gent, Craig Hirte, Alexia Pena, David W. Thomas and Jennifer J. Couper
    Diabetes 2002 Jul; 51 (7): 2282-2286. https://doi.org/10.2337/diabetes.51.7.2282
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    Hyperketonemia Increases Tumor Necrosis Factor-α Secretion in Cultured U937 Monocytes and Type 1 Diabetic Patients and Is Apparently Mediated by Oxidative Stress and cAMP Deficiency
    Sushil K. Jain, Krishnaswamy Kannan, Gideon Lim, Robert McVie and Joseph A. Bocchini
    Diabetes 2002 Jul; 51 (7): 2287-2293. https://doi.org/10.2337/diabetes.51.7.2287
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Epidemiology

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    Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians
    Babatunji-William Ogunkolade, Barbara J. Boucher, Jean M. Prahl, Stephen A. Bustin, Jacky M. Burrin, Kate Noonan, Bernard V. North, Nassima Mannan, Michael F. McDermott, Hector F. DeLuca and Graham A. Hitman
    Diabetes 2002 Jul; 51 (7): 2294-2300. https://doi.org/10.2337/diabetes.51.7.2294
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Genetics

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    Loss of Kinase Activity in a Patient With Wolcott-Rallison Syndrome Caused By a Novel Mutation in the EIF2AK3 Gene
    Anna Biason-Lauber, Mariarosaria Lang-Muritano, Tindara Vaccaro and Eugen J. Schoenle
    Diabetes 2002 Jul; 51 (7): 2301-2305. https://doi.org/10.2337/diabetes.51.7.2301
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    A Haplotype at the Adiponectin Locus Is Associated With Obesity and Other Features of the Insulin Resistance Syndrome
    Claudia Menzaghi, Tonino Ercolino, Rosa Di Paola, Anders H. Berg, James H. Warram, Philipp E. Scherer, Vincenzo Trischitta and Alessandro Doria
    Diabetes 2002 Jul; 51 (7): 2306-2312. https://doi.org/10.2337/diabetes.51.7.2306
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Brief Genetics Report

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    A Putative Functional Polymorphism in the IGF-I GeneAssociation Studies With Type 2 Diabetes, Adult Height, Glucose Tolerance, and Fetal Growth in U.K. Populations
    Timothy M. Frayling, Andrew T. Hattersley, Anne McCarthy, Jeff Holly, Simon M.S. Mitchell, Anna L. Gloyn, Katharine Owen, David Davies, George Davey Smith and Yoav Ben-Shlomo
    Diabetes 2002 Jul; 51 (7): 2313-2316. https://doi.org/10.2337/diabetes.51.7.2313
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    Defining the Importance of Mitochondrial Gene Defects in Maternally Inherited Diabetes by Sequencing the Entire Mitochondrial Genome
    Alan T.W. Choo-Kang, Stephen Lynn, Geoffrey A. Taylor, Mark E. Daly, Sarbpreet S. Sihota, Teressa M. Wardell, Patrick F. Chinnery, Douglass M. Turnbull and Mark Walker
    Diabetes 2002 Jul; 51 (7): 2317-2320. https://doi.org/10.2337/diabetes.51.7.2317
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    The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-γ2 Gene on Insulin Sensitivity and Insulin Metabolism Interact With Size at Birth
    Johan G. Eriksson, Virpi Lindi, Matti Uusitupa, Tom J. Forsén, Markku Laakso, Clive Osmond and David J.P. Barker
    Diabetes 2002 Jul; 51 (7): 2321-2324. https://doi.org/10.2337/diabetes.51.7.2321
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    Association of Adiponectin Mutation With Type 2 DiabetesA Candidate Gene for the Insulin Resistance Syndrome
    Hidehiko Kondo, Iichiro Shimomura, Yuko Matsukawa, Masahiro Kumada, Masahiko Takahashi, Morihiro Matsuda, Noriyuki Ouchi, Shinji Kihara, Toshiharu Kawamoto, Satoru Sumitsuji, Tohru Funahashi and Yuji Matsuzawa
    Diabetes 2002 Jul; 51 (7): 2325-2328. https://doi.org/10.2337/diabetes.51.7.2325
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    Maturity-Onset Diabetes of the Young Caused by a Balanced Translocation Where the 20q12 Break Point Results in Disruption Upstream of the Coding Region of Hepatocyte Nuclear Factor-4α (HNF4A) Gene
    Anna L. Gloyn, Sian Ellard, Maggie Shepherd, Rodney T. Howell, Elizabeth M. Parry, Andrew Jefferson, Elaine R. Levy and Andrew T. Hattersley
    Diabetes 2002 Jul; 51 (7): 2329-2333. https://doi.org/10.2337/diabetes.51.7.2329
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    IL-12p40 Is Associated With Type 1 Diabetes in Caucasian-American Families
    Abdoreza Davoodi-Semiromi, James J. Yang and Jin-Xiong She
    Diabetes 2002 Jul; 51 (7): 2334-2336. https://doi.org/10.2337/diabetes.51.7.2334
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July 2002, 51(7)
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