Diabetes: 51 (8)

August 01 2002; volume 51 issue 8

Perspectives in Diabetes

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The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism
Michael Stumvoll and Hans Häring

Diabetes 2002 Aug; 51 (8): 2341-2347. https://doi.org/10.2337/diabetes.51.8.2341

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Cross-Talk Between Iron Metabolism and Diabetes
José Manuel Fernández-Real, Abel López-Bermejo and Wifredo Ricart

Diabetes 2002 Aug; 51 (8): 2348-2354. https://doi.org/10.2337/diabetes.51.8.2348

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A Genetic Switch in Pancreatic β-CellsImplications for Differentiation and Haploinsufficiency
Jorge Ferrer

Diabetes 2002 Aug; 51 (8): 2355-2362. https://doi.org/10.2337/diabetes.51.8.2355

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Metabolism and Signal Transduction

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Effects of Benfluorex on Fatty Acid and Glucose Metabolism in Isolated Rat HepatocytesFrom Metabolic Fluxes to Gene Expression
Claude Kohl, Denis Ravel, Jean Girard and Jean-Paul Pégorier

Diabetes 2002 Aug; 51 (8): 2363-2368. https://doi.org/10.2337/diabetes.51.8.2363

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Impairment of Insulin Signaling in Human Skeletal Muscle Cells by Co-Culture With Human Adipocytes
Daniela Dietze, Marlis Koenen, Karin Röhrig, Hiroyoshi Horikoshi, Hans Hauner and Jürgen Eckel

Diabetes 2002 Aug; 51 (8): 2369-2376. https://doi.org/10.2337/diabetes.51.8.2369

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Regulatory Effects of HMG CoA Reductase Inhibitor and Fish Oils on Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Male Subjects With Dyslipidemia
Dick C. Chan, Gerald F. Watts, P. Hugh R. Barrett, Lawrence J. Beilin, Trevor G. Redgrave and Trevor A. Mori

Diabetes 2002 Aug; 51 (8): 2377-2386. https://doi.org/10.2337/diabetes.51.8.2377

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Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice
Hiroyuki Hori, Toshiyasu Sasaoka, Hajime Ishihara, Tsutomu Wada, Shihou Murakami, Manabu Ishiki and Masashi Kobayashi

Diabetes 2002 Aug; 51 (8): 2387-2394. https://doi.org/10.2337/diabetes.51.8.2387

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Synthesis Rate of Muscle Proteins, Muscle Functions, and Amino Acid Kinetics in Type 2 Diabetes
Panagiotis Halvatsiotis, Kevin R. Short, Maureen Bigelow and K. Sreekumaran Nair

Diabetes 2002 Aug; 51 (8): 2395-2404. https://doi.org/10.2337/diabetes.51.8.2395

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Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis
Cristina M. Rondinone, James M. Trevillyan, Jill Clampit, Rebecca J. Gum, Cathy Berg, Paul Kroeger, Leigh Frost, Bradley A. Zinker, Regina Reilly, Roger Ulrich, Madeline Butler, Brett P. Monia, Michael R. Jirousek and Jeffrey F. Waring

Diabetes 2002 Aug; 51 (8): 2405-2411. https://doi.org/10.2337/diabetes.51.8.2405

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Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists
Guoqiang Jiang, Qing Dallas-Yang, Zhihua Li, Deborah Szalkowski, Franklin Liu, Xiaolan Shen, Margaret Wu, Gaochao Zhou, Thomas Doebber, Joel Berger, David E. Moller and Bei B. Zhang

Diabetes 2002 Aug; 51 (8): 2412-2419. https://doi.org/10.2337/diabetes.51.8.2412

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The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism
Simon A. Hawley, Anne E. Gadalla, Grith Skytte Olsen and D. Grahame Hardie

Diabetes 2002 Aug; 51 (8): 2420-2425. https://doi.org/10.2337/diabetes.51.8.2420

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Liver X Receptors Downregulate 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity
Thomas M. Stulnig, Udo Oppermann, Knut R. Steffensen, Gertrud U. Schuster and Jan-Åke Gustafsson

Diabetes 2002 Aug; 51 (8): 2426-2433. https://doi.org/10.2337/diabetes.51.8.2426

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Obesity Studies

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Leptin Potentiates Thermogenic Sympathetic Responses to HypothermiaA Receptor-Mediated Effect
Martin Hausberg, Donald A. Morgan, Jennifer L. Mitchell, William I. Sivitz, Allyn L. Mark and William G. Haynes

Diabetes 2002 Aug; 51 (8): 2434-2440. https://doi.org/10.2337/diabetes.51.8.2434

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Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats
Andrew V. Turnbull, Laraine Ellershaw, Dave J. Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J.G. Loxham, Pat McAulay, Joanne L. Teague, Kevin M. Foote, J. Elizabeth Pease and Michael H. Block

Diabetes 2002 Aug; 51 (8): 2441-2449. https://doi.org/10.2337/diabetes.51.8.2441

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Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene
Suresh T. Mathews, Gurmant P. Singh, Mollie Ranalletta, Vivian J. Cintron, Xiaoling Qiang, Anton Scott Goustin, Kai-Lin Catherine Jen, Maureen J. Charron, Willi Jahnen-Dechent and George Grunberger

Diabetes 2002 Aug; 51 (8): 2450-2458. https://doi.org/10.2337/diabetes.51.8.2450

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Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women
Mary-Ellen Harper, Robert Dent, Shadi Monemdjou, Véronic Bézaire, Lloyd Van Wyck, George Wells, Gul Nihan Kavaslar, Andre Gauthier, Frédérique Tesson and Ruth McPherson

Diabetes 2002 Aug; 51 (8): 2459-2466. https://doi.org/10.2337/diabetes.51.8.2459

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Impaired Postprandial Adipose Tissue Blood Flow Response Is Related to Aspects of Insulin Sensitivity
Fredrik Karpe, Barbara A. Fielding, Vera Ilic, Ian A. Macdonald, Lucinda K.M. Summers and Keith N. Frayn

Diabetes 2002 Aug; 51 (8): 2467-2473. https://doi.org/10.2337/diabetes.51.8.2467

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Immunology and Transplantation

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Reduced Expression of Th1-Associated Chemokine Receptors on Peripheral Blood Lymphocytes at Diagnosis of Type 1 Diabetes
T. Lohmann, S. Laue, U. Nietzschmann, T.M. Kapellen, I. Lehmann, S. Schroeder, R. Paschke and W. Kiess

Diabetes 2002 Aug; 51 (8): 2474-2480. https://doi.org/10.2337/diabetes.51.8.2474

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Phagocytosis of Apoptotic Cells by Macrophages From NOD Mice Is Reduced
Bronwyn A. O’Brien, Yongqian Huang, Xuan Geng, Jan P. Dutz and Diane T. Finegood

Diabetes 2002 Aug; 51 (8): 2481-2488. https://doi.org/10.2337/diabetes.51.8.2481

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The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection
Reza Abdi, R. Neal Smith, Leila Makhlouf, Nader Najafian, Andrew D. Luster, Hugh Auchincloss and Mohamed H. Sayegh

Diabetes 2002 Aug; 51 (8): 2489-2495. https://doi.org/10.2337/diabetes.51.8.2489

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Islet Studies

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Succinate Is a Preferential Metabolic Stimulus-Coupling Signal for Glucose-Induced Proinsulin Biosynthesis Translation
Cristina Alarcon, Barton Wicksteed, Marc Prentki, Barbara E. Corkey and Christopher J. Rhodes

Diabetes 2002 Aug; 51 (8): 2496-2504. https://doi.org/10.2337/diabetes.51.8.2496

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PDX-1 Induces Differentiation of Intestinal Epithelioid IEC-6 Into Insulin-Producing Cells
Shigeru Yoshida, Yoshitaka Kajimoto, Tetsuyuki Yasuda, Hirotaka Watada, Yoshio Fujitani, Hiroshi Kosaka, Takahiro Gotow, Takeshi Miyatsuka, Yutaka Umayahara, Yoshimitsu Yamasaki and Masatsugu Hori

Diabetes 2002 Aug; 51 (8): 2505-2513. https://doi.org/10.2337/diabetes.51.8.2505

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Sulfatide Controls Insulin Secretion by Modulation of ATP-sensitive K⁺-Channel Activity and Ca²⁺-Dependent Exocytosis in Rat Pancreatic β-Cells
Karsten Buschard, Marianne Høy, Krister Bokvist, Hervør L. Olsen, Sten Madsbad, Pam Fredman and Jesper Gromada

Diabetes 2002 Aug; 51 (8): 2514-2521. https://doi.org/10.2337/diabetes.51.8.2514

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Ouabain Suppresses Glucose-Induced Mitochondrial ATP Production and Insulin Release by Generating Reactive Oxygen Species in Pancreatic Islets
Mariko Kajikawa, Shimpei Fujimoto, Yoshiyuki Tsuura, Eri Mukai, Tomomi Takeda, Yoshiyuki Hamamoto, Mihoko Takehiro, Jun Fujita, Yuichiro Yamada and Yutaka Seino

Diabetes 2002 Aug; 51 (8): 2522-2529. https://doi.org/10.2337/diabetes.51.8.2522

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Islet Hyperperfusion During Prediabetic Phase in OLETF Rats, a Model of Type 2 Diabetes
Masanori Iwase, Yuji Uchizono, Kenji Tashiro, Daisuke Goto and Mitsuo Iida

Diabetes 2002 Aug; 51 (8): 2530-2535. https://doi.org/10.2337/diabetes.51.8.2530

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Stimulation of Acetyl-CoA Carboxylase Gene Expression by Glucose Requires Insulin Release and Sterol Regulatory Element Binding Protein 1c in Pancreatic MIN6 β-Cells
Chrysovalantis Andreolas, Gabriela da Silva Xavier, Frederique Diraison, Chao Zhao, Aniko Varadi, Fernando Lopez-Casillas, Pascal Ferré, Fabienne Foufelle and Guy A. Rutter

Diabetes 2002 Aug; 51 (8): 2536-2545. https://doi.org/10.2337/diabetes.51.8.2536

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Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In Vivo
Catherine S. Lee, Newman J. Sund, Marko Z. Vatamaniuk, Franz M. Matschinsky, Doris A. Stoffers and Klaus H. Kaestner

Diabetes 2002 Aug; 51 (8): 2546-2551. https://doi.org/10.2337/diabetes.51.8.2546

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Increased Glucose Sensitivity of Stimulus-Secretion Coupling in Islets From Psammomys obesus After Diet Induction of Diabetes
Jose A.G. Pertusa, Rafael Nesher, Nurit Kaiser, Erol Cerasi, Jean-Claude Henquin and Jean-Christophe Jonas

Diabetes 2002 Aug; 51 (8): 2552-2560. https://doi.org/10.2337/diabetes.51.8.2552

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Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound
Rita Bottino, A.N. Balamurugan, Suzanne Bertera, Massimo Pietropaolo, Massimo Trucco and Jon D. Piganelli

Diabetes 2002 Aug; 51 (8): 2561-2567. https://doi.org/10.2337/diabetes.51.8.2561

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Pathophysiology

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Maternal First-Trimester Enterovirus Infection and Future Risk of Type 1 Diabetes in the Exposed Fetus
Hanna R. Viskari, Merja Roivainen, Antti Reunanen, Janne Pitkäniemi, Karita Sadeharju, Pentti Koskela, Tapani Hovi, Pauli Leinikki, Pekka Vilja, Jaakko Tuomilehto and Heikki Hyöty

Diabetes 2002 Aug; 51 (8): 2568-2571. https://doi.org/10.2337/diabetes.51.8.2568

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Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than in Control Subjects
Bronwyn A. Kingwell, Melissa Formosa, Michael Muhlmann, Scott J. Bradley and Glenn K. McConell

Diabetes 2002 Aug; 51 (8): 2572-2580. https://doi.org/10.2337/diabetes.51.8.2572

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Association of the Pro12Ala Polymorphism in the PPAR-γ2 Gene With 3-Year Incidence of Type 2 Diabetes and Body Weight Change in the Finnish Diabetes Prevention Study
Virpi I. Lindi, Matti I.J. Uusitupa, Jaana Lindström, Anne Louheranta, Johan G. Eriksson, Timo T. Valle, Helena Hämäläinen, Pirjo Ilanne-Parikka, Sirkka Keinänen-Kiukaanniemi, Markku Laakso and Jaakko Tuomilehto

Diabetes 2002 Aug; 51 (8): 2581-2586. https://doi.org/10.2337/diabetes.51.8.2581

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Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart
Martin E. Young, Patrick H. Guthrie, Peter Razeghi, Brendan Leighton, Shahrzad Abbasi, Sarita Patil, Keith A. Youker and Heinrich Taegtmeyer

Diabetes 2002 Aug; 51 (8): 2587-2595. https://doi.org/10.2337/diabetes.51.8.2587

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Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes
J.A. Paniagua, J. López-Miranda, A. Escribano, F.J. Berral, C. Marín, D. Bravo, E. Paz-Rojas, P. Gómez, M. Barcos, J.A. Moreno and F. Pérez-Jiménez

Diabetes 2002 Aug; 51 (8): 2596-2603. https://doi.org/10.2337/diabetes.51.8.2596

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Complications

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Hepatocyte Growth Factor Prevents Endothelial Cell Death Through Inhibition of bax Translocation From Cytosol to Mitochondrial Membrane
Hironori Nakagami, Ryuichi Morishita, Kei Yamamoto, Yoshiaki Taniyama, Motokuni Aoki, Keita Yamasaki, Kunio Matsumoto, Toshikazu Nakamura, Yasufumi Kaneda and Toshio Ogihara

Diabetes 2002 Aug; 51 (8): 2604-2611. https://doi.org/10.2337/diabetes.51.8.2604

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Effects of Mesangium Glycation on Matrix Metalloproteinase ActivitiesPossible Role in Diabetic Nephropathy
S.V. McLennan, S.K.Y. Martell and D.K. Yue

Diabetes 2002 Aug; 51 (8): 2612-2618. https://doi.org/10.2337/diabetes.51.8.2612

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Dissection of Metabolic, Vascular, and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl-l-Carnitine Administration
Rodica Pop-Busui, Victor Marinescu, Carol Van Huysen, Fei Li, Kelli Sullivan, Douglas A. Greene, Dennis Larkin and Martin J. Stevens

Diabetes 2002 Aug; 51 (8): 2619-2628. https://doi.org/10.2337/diabetes.51.8.2619

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Low Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Are Closely Associated With the Presence of Macrovascular Disease and Hypertension in Type 2 Diabetes
Adrian H. Heald, K.W. Siddals, William Fraser, William Taylor, Kalpana Kaushal, Julie Morris, Robert J. Young, Anne White and J. Martin Gibson

Diabetes 2002 Aug; 51 (8): 2629-2636. https://doi.org/10.2337/diabetes.51.8.2629

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Silent Coronary Atheromatosis in Type 1 Diabetic Patients and Its Relation to Long-Term Glycemic Control
Jakob Larsen, Magne Brekke, Leiv Sandvik, Harald Arnesen, Kristian F. Hanssen and Knut Dahl-Jorgensen

Diabetes 2002 Aug; 51 (8): 2637-2641. https://doi.org/10.2337/diabetes.51.8.2637

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Factor Analysis of Metabolic Syndrome Using Directly Measured Insulin SensitivityThe Insulin Resistance Atherosclerosis Study
Anthony J.G. Hanley, Andrew J. Karter, Andreas Festa, Ralph D’Agostino, Lynne E. Wagenknecht, Peter Savage, Russell P. Tracy, Mohammed F. Saad and Steven Haffner

Diabetes 2002 Aug; 51 (8): 2642-2647. https://doi.org/10.2337/diabetes.51.8.2642

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Glucose Increases Endothelial-Dependent Superoxide Formation in Coronary Arteries by NAD(P)H Oxidase ActivationAttenuation by the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor Atorvastatin
Michael Christ, Johann Bauersachs, Claudia Liebetrau, Marina Heck, Andreas Günther and Martin Wehling

Diabetes 2002 Aug; 51 (8): 2648-2652. https://doi.org/10.2337/diabetes.51.8.2648

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Genetics

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Peroxisome Proliferator-Activated Receptor-γ2 Polymorphism Pro12Ala Is Associated With Nephropathy in Type 2 DiabetesThe Berlin Diabetes Mellitus (BeDiaM) Study
Stefan-Martin Herrmann, Jens Ringel, Ji-Guang Wang, Jan A. Staessen and Eva Brand

Diabetes 2002 Aug; 51 (8): 2653-2657. https://doi.org/10.2337/diabetes.51.8.2653

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Variants in the Calpain-10 Gene Predispose to Insulin Resistance and Elevated Free Fatty Acid Levels
Marju Orho-Melander, Mia Klannemark, Malin K. Svensson, Martin Ridderstråle, Cecilia M. Lindgren and Leif Groop

Diabetes 2002 Aug; 51 (8): 2658-2664. https://doi.org/10.2337/diabetes.51.8.2658

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Erratum

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Errata
Diabetes 2002 Aug; 51 (8): 2665. https://doi.org/10.2337/diabetes.51.8.2665

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Errata
Diabetes 2002 Aug; 51 (8): 2665. https://doi.org/10.2337/diabetes.51.8.2665-a

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Table of Contents

Perspectives in Diabetes

Metabolism and Signal Transduction

Obesity Studies

Immunology and Transplantation

Islet Studies

Pathophysiology

Complications

Genetics

Erratum

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