Diabetes: 51 (9)

September 01 2002; volume 51 issue 9

Perspectives in Diabetes

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The Succinate Mechanism of Insulin Release
Leonard A. Fahien and Michael J. MacDonald

Diabetes 2002 Sep; 51 (9): 2669-2676. https://doi.org/10.2337/diabetes.51.9.2669

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Metabolism and Signal Transduction

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Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker RatA Euglycemic-Hyperinsulinemic Clamp Study
John A. Pospisilik, Sara G. Stafford, Hans-Ulrich Demuth, Christopher H.S. McIntosh and Raymond A. Pederson

Diabetes 2002 Sep; 51 (9): 2677-2683. https://doi.org/10.2337/diabetes.51.9.2677

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Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle
Kevin Evans, Graham C. Burdge, Stephen A. Wootton, Mo L. Clark and Keith N. Frayn

Diabetes 2002 Sep; 51 (9): 2684-2690. https://doi.org/10.2337/diabetes.51.9.2684

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Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes
Marco M. Meyer, Klaus Levin, Thomas Grimmsmann, Nina Perwitz, Alexandra Eirich, Henning Beck-Nielsen and Harald H. Klein

Diabetes 2002 Sep; 51 (9): 2691-2697. https://doi.org/10.2337/diabetes.51.9.2691

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Muscle Glucose Uptake Does Not Increase When Only Local Arterial Glucose Concentration Is Increased
Kenneth Zierler and Reubin Andres

Diabetes 2002 Sep; 51 (9): 2698-2702. https://doi.org/10.2337/diabetes.51.9.2698

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Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction
Brian R. Barnes, Jeffrey W. Ryder, Tatiana L. Steiler, Lee G.D. Fryer, David Carling and Juleen R. Zierath

Diabetes 2002 Sep; 51 (9): 2703-2708. https://doi.org/10.2337/diabetes.51.9.2703

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Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes
Kerrie J. Way, Keiji Isshiki, Kiyoshi Suzuma, Tamotsu Yokota, Dmitriy Zvagelsky, Frederick J. Schoen, George E. Sandusky, Penelope A. Pechous, Chris J. Vlahos, Hisao Wakasaki and George L. King

Diabetes 2002 Sep; 51 (9): 2709-2718. https://doi.org/10.2337/diabetes.51.9.2709

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Need for GLUT4 Activation to Reach Maximum Effect of Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice
Daniel Konrad, Philip J. Bilan, Zafar Nawaz, Gary Sweeney, Wenyan Niu, Zhi Liu, Costin N. Antonescu, Assaf Rudich and Amira Klip

Diabetes 2002 Sep; 51 (9): 2719-2726. https://doi.org/10.2337/diabetes.51.9.2719

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Obesity Studies

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Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy
Carlo Colombo, Jaime J. Cutson, Toshimasa Yamauchi, Charles Vinson, Takashi Kadowaki, Oksana Gavrilova and Marc L. Reitman

Diabetes 2002 Sep; 51 (9): 2727-2733. https://doi.org/10.2337/diabetes.51.9.2727

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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Hitoshi Nishizawa, Iichiro Shimomura, Ken Kishida, Norikazu Maeda, Hiroshi Kuriyama, Hiroyuki Nagaretani, Morihiro Matsuda, Hidehiko Kondo, Naoki Furuyama, Shinji Kihara, Tadashi Nakamura, Yoshihiro Tochino, Tohru Funahashi and Yuji Matsuzawa

Diabetes 2002 Sep; 51 (9): 2734-2741. https://doi.org/10.2337/diabetes.51.9.2734

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Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects
Mikaela Sjöstrand, Soffia Gudbjörnsdottir, Agneta Holmäng, Lars Lönn, Lena Strindberg and Peter Lönnroth

Diabetes 2002 Sep; 51 (9): 2742-2748. https://doi.org/10.2337/diabetes.51.9.2742

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Islet Studies

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Role of ATP Production and Uncoupling Protein-2 in the Insulin Secretory Defect Induced by Chronic Exposure to High Glucose or Free Fatty Acids and Effects of Peroxisome Proliferator-Activated Receptor-γ Inhibition
Giovanni Patanè, Marcello Anello, Salvatore Piro, Riccardo Vigneri, Francesco Purrello and Agata Maria Rabuazzo

Diabetes 2002 Sep; 51 (9): 2749-2756. https://doi.org/10.2337/diabetes.51.9.2749

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Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells
Frank Reimann and Fiona M. Gribble

Diabetes 2002 Sep; 51 (9): 2757-2763. https://doi.org/10.2337/diabetes.51.9.2757

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Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic β-Cells by Transcriptional Activation of the GAD67 Promoter and Its Possible Effect on the Development of Diabetes
Kyung Soo Kim, Yup Kang, Sung E. Choi, Ju Hee Kim, Hyeon Man Kim, Beichen Sun, Hee-Sook Jun and Ji-Won Yoon

Diabetes 2002 Sep; 51 (9): 2764-2772. https://doi.org/10.2337/diabetes.51.9.2764

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Plasma Membrane Ca²⁺-ATPase Overexpression Reduces Ca²⁺ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells
Adama Kamagate, André Herchuelz and Françoise Van Eylen

Diabetes 2002 Sep; 51 (9): 2773-2788. https://doi.org/10.2337/diabetes.51.9.2773

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Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1
Ann Maria K. Hansen, Inge T. Christensen, John Bondo Hansen, Richard D. Carr, Frances M. Ashcroft and Philip Wahl

Diabetes 2002 Sep; 51 (9): 2789-2795. https://doi.org/10.2337/diabetes.51.9.2789

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Pathophysiology

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Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women
Thomas A. Buchanan, Anny H. Xiang, Ruth K. Peters, Siri L. Kjos, Aura Marroquin, Jose Goico, Cesar Ochoa, Sylvia Tan, Kathleen Berkowitz, Howard N. Hodis and Stanley P. Azen

Diabetes 2002 Sep; 51 (9): 2796-2803. https://doi.org/10.2337/diabetes.51.9.2796

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Complications

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Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy
Yuji Hiramatsu, Naotaka Sekiguchi, Michio Hayashi, Keiji Isshiki, Tamotsu Yokota, George L. King and Mary R. Loeken

Diabetes 2002 Sep; 51 (9): 2804-2810. https://doi.org/10.2337/diabetes.51.9.2804

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Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid
Billy W.H. Chan, Kwok-siu Chan, Tsuyoshi Koide, Sau-man Yeung, Maran B.W. Leung, Andrew J. Copp, Mary R. Loeken, Toshihiko Shiroishi and Alisa S.W. Shum

Diabetes 2002 Sep; 51 (9): 2811-2816. https://doi.org/10.2337/diabetes.51.9.2811

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Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes
Robert D. Hoeldtke, Kimberly D. Bryner, Daniel R. McNeill, Gerald R. Hobbs, Jack E. Riggs, Sarah S. Warehime, Ian Christie, Gary Ganser and Knox Van Dyke

Diabetes 2002 Sep; 51 (9): 2817-2825. https://doi.org/10.2337/diabetes.51.9.2817

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The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes
Alan Stitt, Thomas A. Gardiner, Nathan L. Anderson, Paul Canning, Norma Frizzell, Noel Duffy, Cliona Boyle, Andrzej S. Januszewski, Mark Chachich, John W. Baynes and Suzanne R. Thorpe

Diabetes 2002 Sep; 51 (9): 2826-2832. https://doi.org/10.2337/diabetes.51.9.2826

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Peroxynitrite Induces Formation of N^ε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From GlucoseNovel Pathways for Protein Modification by Peroxynitrite
Ryoji Nagai, Yuka Unno, Miki Cristina Hayashi, Shuichi Masuda, Fumitaka Hayase, Naohide Kinae and Seikoh Horiuchi

Diabetes 2002 Sep; 51 (9): 2833-2839. https://doi.org/10.2337/diabetes.51.9.2833

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Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles
Florence Sabatier, Patrice Darmon, Benedicte Hugel, Valery Combes, Marielle Sanmarco, Jean-Gabriel Velut, Dominique Arnoux, Phillipe Charpiot, Jean-Marie Freyssinet, Charles Oliver, Jose Sampol and Francoise Dignat-George

Diabetes 2002 Sep; 51 (9): 2840-2845. https://doi.org/10.2337/diabetes.51.9.2840

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Augmentation of the Neutrophil Respiratory Burst Through the Action of Advanced Glycation End ProductsA Potential Contributor to Vascular Oxidant Stress
Richard K.M. Wong, Andrew I. Pettit, Joan E. Davies and Leong L. Ng

Diabetes 2002 Sep; 51 (9): 2846-2853. https://doi.org/10.2337/diabetes.51.9.2846

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Genetics

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The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia
Otto Tschritter, Michael Stumvoll, Fausto Machicao, Martin Holzwarth, Melanie Weisser, Elke Maerker, Anna Teigeler, Hans Häring and Andreas Fritsche

Diabetes 2002 Sep; 51 (9): 2854-2860. https://doi.org/10.2337/diabetes.51.9.2854

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Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians
Hua Wang, Winston Chu, Swapan K. Das, Qianfang Ren, Sandra J. Hasstedt and Steven C. Elbein

Diabetes 2002 Sep; 51 (9): 2861-2865. https://doi.org/10.2337/diabetes.51.9.2861

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Brief Genetics Report

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A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes
Gillian C.L. Johnson, Felicity Payne, Sarah Nutland, Helen Stevens, Eva Tuomilehto-Wolf, Jaakko Tuomilehto and John A. Todd

Diabetes 2002 Sep; 51 (9): 2866-2870. https://doi.org/10.2337/diabetes.51.9.2866

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Polymorphic Susceptibility to the Molecular Causes of Neural Tube Defects During Diabetic Embryopathy
Lydie Pani, Melissa Horal and Mary R. Loeken

Diabetes 2002 Sep; 51 (9): 2871-2874. https://doi.org/10.2337/diabetes.51.9.2871

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Perspectives in Diabetes

Metabolism and Signal Transduction

Obesity Studies

Islet Studies

Pathophysiology

Complications

Genetics

Brief Genetics Report

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