β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler; Juliette Janson; Susan Bonner-Weir; Robert Ritzel; Robert A. Rizza; Peter C. Butler

doi:10.2337/diabetes.52.1.102

Islet Studies

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler1,
Juliette Janson2,
Susan Bonner-Weir3,
Robert Ritzel1,
Robert A. Rizza4 and
Peter C. Butler1

¹Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California
²Karolinska Institute, Stockholm, Sweden
³Joslin Diabetes Center, Boston, Massachusetts
⁴Division of Endocrinology, Mayo Clinic, Rochester, Minnesota

Diabetes 2003 Jan; 52(1): 102-110. https://doi.org/10.2337/diabetes.52.1.102

Article Information

vol. 52 no. 1 102-110

DOI

https://doi.org/10.2337/diabetes.52.1.102

PubMed

12502499

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Published in print January 1, 2003.

DIABETES

Author Information

Alexandra E. Butler1,
Juliette Janson2,
Susan Bonner-Weir3,
Robert Ritzel1,
Robert A. Rizza4 and
Peter C. Butler1

¹Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California
²Karolinska Institute, Stockholm, Sweden
³Joslin Diabetes Center, Boston, Massachusetts
⁴Division of Endocrinology, Mayo Clinic, Rochester, Minnesota

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: December 2002 to March 2020

Rendering graph...

	Abstract	Full	Pdf
Dec 2002	76	17	77
Jan 2003	152	422	348
Feb 2003	73	254	144
Mar 2003	64	211	133
Apr 2003	64	164	83
May 2003	47	146	91
Jun 2003	40	106	59
Jul 2003	49	127	63
Aug 2003	61	97	36
Sep 2003	66	92	61
Oct 2003	73	119	53
Nov 2003	86	118	68
Dec 2003	42	74	60
Jan 2004	30	98	110
Feb 2004	50	142	161
Mar 2004	54	149	132
Apr 2004	35	116	78
May 2004	54	118	112
Jun 2004	34	111	133
Jul 2004	32	144	184
Aug 2004	50	125	157
Sep 2004	44	136	136
Oct 2004	48	155	142
Nov 2004	64	184	164
Dec 2004	62	103	99
Jan 2005	49	121	113
Feb 2005	63	144	158
Mar 2005	68	154	208
Apr 2005	44	145	181
May 2005	52	205	146
Jun 2005	29	129	108
Jul 2005	36	117	122
Aug 2005	33	142	105
Sep 2005	19	120	126
Oct 2005	44	166	129
Nov 2005	63	204	189
Dec 2005	36	115	96
Jan 2006	37	150	120
Feb 2006	37	154	128
Mar 2006	58	154	162
Apr 2006	69	199	157
May 2006	44	141	127
Jun 2006	58	142	141
Jul 2006	54	131	138
Aug 2006	44	116	126
Sep 2006	39	123	109
Oct 2006	54	154	151
Nov 2006	47	149	150
Dec 2006	35	137	96
Jan 2007	68	154	148
Feb 2007	43	137	151
Mar 2007	51	176	128
Apr 2007	90	218	178
May 2007	46	149	175
Jun 2007	50	108	129
Jul 2007	53	144	127
Aug 2007	38	100	117
Sep 2007	40	115	111
Oct 2007	50	132	154
Nov 2007	84	157	175
Dec 2007	90	126	139
Jan 2008	114	129	154
Feb 2008	119	157	193
Mar 2008	135	175	213
Apr 2008	218	185	215
May 2008	299	163	204
Jun 2008	246	183	135
Jul 2008	186	147	171
Aug 2008	135	162	167
Sep 2008	47	159	157
Oct 2008	70	163	186
Nov 2008	76	156	183
Dec 2008	60	104	120
Jan 2009	58	151	153
Feb 2009	60	160	191
Mar 2009	74	227	206
Apr 2009	60	211	173
May 2009	38	111	116
Jun 2009	73	136	107
Jul 2009	94	242	174
Aug 2009	73	242	107
Sep 2009	77	341	138
Oct 2009	137	512	179
Nov 2009	148	313	218
Dec 2009	83	295	155
Jan 2010	74	263	161
Feb 2010	113	301	197
Mar 2010	113	387	236
Apr 2010	96	408	161
May 2010	120	348	176
Jun 2010	106	378	183
Jul 2010	72	275	121
Aug 2010	67	364	158
Sep 2010	91	376	150
Oct 2010	86	535	214
Nov 2010	89	469	186
Dec 2010	50	354	145
Jan 2011	84	527	174
Feb 2011	101	593	228
Mar 2011	262	444	248
Apr 2011	347	289	235
May 2011	321	269	312
Jun 2011	241	247	249
Jul 2011	216	239	238
Aug 2011	255	298	227
Sep 2011	397	291	209
Oct 2011	500	404	258
Nov 2011	446	270	268
Dec 2011	226	212	311
Jan 2012	303	258	203
Feb 2012	302	211	167
Mar 2012	388	329	269
Apr 2012	440	379	256
May 2012	430	311	226
Jun 2012	325	206	215
Jul 2012	277	231	195
Aug 2012	234	205	181
Sep 2012	311	233	184
Oct 2012	422	284	247
Nov 2012	391	340	272
Dec 2012	305	258	229
Jan 2013	402	391	212
Feb 2013	347	319	185
Mar 2013	437	333	263
Apr 2013	610	424	269
May 2013	506	385	289
Jun 2013	284	294	179
Jul 2013	716	292	216
Aug 2013	525	253	169
Sep 2013	560	319	220
Oct 2013	704	347	264
Nov 2013	669	379	235
Dec 2013	813	350	205
Jan 2014	1706	394	263
Feb 2014	1533	393	261
Mar 2014	2528	513	330
Apr 2014	2239	499	274
May 2014	1851	453	243
Jun 2014	1148	324	168
Jul 2014	1092	363	220
Aug 2014	1104	379	181
Sep 2014	2556	490	207
Oct 2014	2279	457	234
Nov 2014	1178	490	338
Dec 2014	1765	267	178
Jan 2015	985	308	226
Feb 2015	1106	417	210
Mar 2015	1128	448	321
Apr 2015	2386	435	222
May 2015	1067	398	235
Jun 2015	1004	376	227
Jul 2015	1921	347	238
Aug 2015	654	401	153
Sep 2015	1017	411	207
Oct 2015	2655	400	803
Nov 2015	993	479	1004
Dec 2015	1262	382	663
Jan 2016	1411	328	192
Feb 2016	1106	342	567
Mar 2016	1241	526	300
Apr 2016	1656	485	239
May 2016	1048	713	259
Jun 2016	302	578	318
Jul 2016	301	476	206
Aug 2016	297	541	210
Sep 2016	484	839	301
Oct 2016	604	775	283
Nov 2016	541	877	307
Dec 2016	354	644	326
Jan 2017	355	486	319
Feb 2017	368	717	228
Mar 2017	452	558	222
Apr 2017	496	408	214
May 2017	363	435	223
Jun 2017	236	385	138
Jul 2017	247	422	162
Aug 2017	305	524	167
Sep 2017	365	514	200
Oct 2017	486	589	244
Nov 2017	481	580	286
Dec 2017	310	608	224
Jan 2018	300	521	195
Feb 2018	374	543	219
Mar 2018	505	573	355
Apr 2018	450	553	255
May 2018	374	641	253
Jun 2018	237	794	235
Jul 2018	234	1227	285
Aug 2018	226	990	284
Sep 2018	388	1480	417
Oct 2018	463	1189	455
Nov 2018	514	635	516
Dec 2018	385	575	507
Jan 2019	226	599	289
Feb 2019	94	512	119
Mar 2019	99	415	169
Apr 2019	102	319	152
May 2019	101	434	191
Jun 2019	67	332	124
Jul 2019	70	297	142
Aug 2019	54	405	146
Sep 2019	46	1606	133
Oct 2019	39	488	136
Nov 2019	27	382	115
Dec 2019	33	267	142
Jan 2020	47	293	128
Feb 2020	23	287	86
Mar 2020	52	287	129