Effects of Acute Insulin Excess and Deficiency on Gluconeogenesis and Glycogenolysis in Type 1 Diabetes
Article Figures & Tables
Figures
- FIG. 1.
Effects of subcutaneous insulin injection on serum free insulin and plasma glucose levels and on GIRs (□) and GRd in nine patients with type 1 diabetes. Shown are means ± SE. Statistical analysis: *P < 0.04 vs. 1 h; **P < 0.02 vs. 4 h; ***P < 0.01 vs. 0 h.
- FIG. 2.
Effects of subcutaneous insulin on rates of GNG (A), GL (B), and EGP (C) in nine patients with type 1 diabetes. Statistical analysis: *P < 0.03 vs. 0 h; **P < 0.02 vs. 0 h; ***P < 0.001 vs. 0 h; †P < 0.04 vs. 3 h; ††P < 0.01 vs. 3 h; †††P < 0.001 vs. 3 h.
- FIG. 3.
Effects of subcutaneous insulin on plasma FFA (•) and total ketone body (TKB) levels (○) (A), on rates on fat oxidation (FOX) (B), and on plasma levels of five GNG precursors. Statistical analysis: *P < 0.05 vs. 0 h; **P < 0.03 vs. 0 h; †P < 0.05 vs. 4 h; ††P < 0.01 vs. 4 h.
Tables
- TABLE 1
Patients
Sex (M/F) 1/8 Age (years) 24 ± 3 Weight (kg) 68.8 ± 3.1 Height (cm) 169 ± 4 BMI (kg/m2) 24.2 ± 1.2 Duration of type 1 diabetes (years) 7.5 ± 1.5 HbA1c (%) 7.6 ± 0.7 Insulin dose (units/24 h) 33.3 ± 5.1 -
Data are means ± SE.
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- TABLE 2
Hours 2H · C5 (% enrichment) 2H2O (% enrichment) 2H · C5/2H2O GRa (μmol · kg−1 · min−1) 0 0.152 ± 0.017 0.383 ± 0.010 0.357 ± 0.396 17.4 ± 1.16 1 0.179 ± 0.017 0.373 ± 0.010 0.432 ± 0.034 11.7 ± 2.1 2 0.144 ± 0.021 0.368 ± 0.011 0.346 ± 0.047 20.9 ± 3.9 3 0.118 ± 0.021 0.367 ± 0.011 0.285 ± 0.050 19.9 ± 2.1 4 0.103 ± 0.016 0.367 ± 0.012 0.251 ± 0.040 16.0 ± 1.9 5 0.116 ± 0.020 0.369 ± 0.011 0.282 ± 0.048 15.5 ± 1.8 6 0.134 ± 0.015 0.368 ± 0.009 0.325 ± 0.032 16.0 ± 1.7 7 0.138 ± 0.022 0.351 ± 0.012 0.350 ± 0.055 14.9 ± 1.4 8 0.157 ± 0.023 0.355 ± 0.008 0.389 ± 0.053 13.9 ± 1.4 -
Data are means ± SE.
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