Diabetes: 52 (10)

October 01 2003; volume 52 issue 10

Metabolism

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Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog
Stella P. Kim, Martin Ellmerer, Gregg W. Van Citters and Richard N. Bergman

Diabetes 2003 Oct; 52 (10): 2453-2460. https://doi.org/10.2337/diabetes.52.10.2453

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A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes
Sangeeta Kashyap, Renata Belfort, Amalia Gastaldelli, Thongchai Pratipanawatr, Rachele Berria, Wilailak Pratipanawatr, Mandeep Bajaj, Lawrence Mandarino, Ralph DeFronzo and Kenneth Cusi

Diabetes 2003 Oct; 52 (10): 2461-2474. https://doi.org/10.2337/diabetes.52.10.2461

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Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using ²H Nuclear Magnetic Resonance Spectroscopy
O. Kunert, H. Stingl, E. Rosian, M. Krššák, E. Bernroider, W. Seebacher, K. Zangger, P. Staehr, V. Chandramouli, B.R. Landau, P. Nowotny, W. Waldhäusl, E. Haslinger and M. Roden

Diabetes 2003 Oct; 52 (10): 2475-2482. https://doi.org/10.2337/diabetes.52.10.2475

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Signal Transduction

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Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 ComplexRelative Roles of Growth Hormone and IGF-1 in Insulin Resistance
Martin Haluzik, Shoshana Yakar, Oksana Gavrilova, Jennifer Setser, Yves Boisclair and Derek LeRoith

Diabetes 2003 Oct; 52 (10): 2483-2489. https://doi.org/10.2337/diabetes.52.10.2483

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Obesity Studies

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Insulin Sensitivity, Insulin Secretion, and Abdominal FatThe Insulin Resistance Atherosclerosis Study (IRAS) Family Study
Lynne E. Wagenknecht, Carl D. Langefeld, Ann L. Scherzinger, Jill M. Norris, Steven M. Haffner, Mohammed F. Saad and Richard N. Bergman

Diabetes 2003 Oct; 52 (10): 2490-2496. https://doi.org/10.2337/diabetes.52.10.2490

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Immunology and Transplantation

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Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH₂-Terminal Kinase Signaling
Zhidong Ling, Mark Van de Casteele, Jing Dong, Harry Heimberg, Jacques-Antoine Haefliger, Gérard Waeber, Frans Schuit and Daniel Pipeleers

Diabetes 2003 Oct; 52 (10): 2497-2502. https://doi.org/10.2337/diabetes.52.10.2497

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Islet Studies

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Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet
Mary Kay Treutelaar, Jennifer M. Skidmore, Claudia L. Dias-Leme, Manami Hara, Lizhi Zhang, Diane Simeone, Donna M. Martin and Charles F. Burant

Diabetes 2003 Oct; 52 (10): 2503-2512. https://doi.org/10.2337/diabetes.52.10.2503

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NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat
Richard D. Carr, Christian L. Brand, Thora B. Bodvarsdottir, John B. Hansen and Jeppe Sturis

Diabetes 2003 Oct; 52 (10): 2513-2518. https://doi.org/10.2337/diabetes.52.10.2513

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Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas
Rohan K. Humphrey, Nathan Bucay, Gillian M. Beattie, Ana Lopez, Conrad A. Messam, Vincenzo Cirulli and Alberto Hayek

Diabetes 2003 Oct; 52 (10): 2519-2525. https://doi.org/10.2337/diabetes.52.10.2519

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Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism
Frits Kamp, Nadeem Kizilbash, Barbara E. Corkey, Per-Olof Berggren and James A. Hamilton

Diabetes 2003 Oct; 52 (10): 2526-2531. https://doi.org/10.2337/diabetes.52.10.2526

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Pathophysiology

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Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance4-Year Results From the Finnish Diabetes Prevention Study
Matti Uusitupa, Virpi Lindi, Anne Louheranta, Titta Salopuro, Jaana Lindström and Jaakko Tuomilehto

Diabetes 2003 Oct; 52 (10): 2532-2538. https://doi.org/10.2337/diabetes.52.10.2532

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Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys ObesusA Model of Insulin Resistance and Type 2 Diabetes
Monika Zoltowska, Ehud Ziv, Edgard Delvin, Daniel Sinnett, Ronny Kalman, Carole Garofalo, Ernest Seidman and Emile Levy

Diabetes 2003 Oct; 52 (10): 2539-2545. https://doi.org/10.2337/diabetes.52.10.2539

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Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes
Seppo M. Pöykkö, Eija Kellokoski, Sohvi Hörkkö, Heikki Kauma, Y. Antero Kesäniemi and Olavi Ukkola

Diabetes 2003 Oct; 52 (10): 2546-2553. https://doi.org/10.2337/diabetes.52.10.2546

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Complications

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Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation
Nica M. Borradaile, Linda E. de Dreu and Murray W. Huff

Diabetes 2003 Oct; 52 (10): 2554-2561. https://doi.org/10.2337/diabetes.52.10.2554

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Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways
Cecilia C. Low Wang, Inga Gurevich and Boris Draznin

Diabetes 2003 Oct; 52 (10): 2562-2569. https://doi.org/10.2337/diabetes.52.10.2562

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Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial CellsPotential Role in Diabetic Nephropathy
Shinsuke Kiritoshi, Takeshi Nishikawa, Kazuhiro Sonoda, Daisuke Kukidome, Takahumi Senokuchi, Tomoko Matsuo, Takeshi Matsumura, Hiroshi Tokunaga, Michael Brownlee and Eiichi Araki

Diabetes 2003 Oct; 52 (10): 2570-2577. https://doi.org/10.2337/diabetes.52.10.2570

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Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy
Thierry C. Coste, Alain Gerbi, Philippe Vague, Gérard Pieroni and Denis Raccah

Diabetes 2003 Oct; 52 (10): 2578-2585. https://doi.org/10.2337/diabetes.52.10.2578

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Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes
Shinichi Okada, Kenichi Shikata, Mitsuhiro Matsuda, Daisuke Ogawa, Hitomi Usui, Yuichi Kido, Ryo Nagase, Jun Wada, Yasushi Shikata and Hirofumi Makino

Diabetes 2003 Oct; 52 (10): 2586-2593. https://doi.org/10.2337/diabetes.52.10.2586

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Glucose Induces Clonal Selection and Reversible Dinucleotide Repeat Expansion in Mesangial Cells Isolated from Glomerulosclerosis-Prone Mice
Alessia Fornoni, Oliver Lenz, Liliane J. Striker and Gary E. Striker

Diabetes 2003 Oct; 52 (10): 2594-2602. https://doi.org/10.2337/diabetes.52.10.2594

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Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy
Munehiro Kitada, Daisuke Koya, Toshiro Sugimoto, Motohide Isono, Shin-ichi Araki, Atsunori Kashiwagi and Masakazu Haneda

Diabetes 2003 Oct; 52 (10): 2603-2614. https://doi.org/10.2337/diabetes.52.10.2603

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Endoneurial Capillary Abnormalities Presage Deterioration of Glucose Tolerance and Accompany Peripheral Neuropathy in Man
Soley Thrainsdottir, Rayez A. Malik, Lars B. Dahlin, Peter Wiksell, Karl F. Eriksson, Ingmar Rosén, Jesper Petersson, Douglas A. Greene and Göran Sundkvist

Diabetes 2003 Oct; 52 (10): 2615-2622. https://doi.org/10.2337/diabetes.52.10.2615

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Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial
Jonathan Q. Purnell, Raj K. Dev, Michael W. Steffes, Patricia A. Cleary, Jerry P. Palmer, Irl B. Hirsch, John E. Hokanson and John D. Brunzell

Diabetes 2003 Oct; 52 (10): 2623-2629. https://doi.org/10.2337/diabetes.52.10.2623

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Brief Genetics Reports

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Kir6.2 Polymorphisms Sensitize β-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAsA Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?
Michael J. Riedel, Parveen Boora, Diana Steckley, Gerda de Vries and Peter E. Light

Diabetes 2003 Oct; 52 (10): 2630-2635. https://doi.org/10.2337/diabetes.52.10.2630

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A Novel Gene for Neonatal Diabetes Maps to Chromosome 10p12.1-p13
Gabrielle S. Sellick, Christine Garrett and Richard S. Houlston

Diabetes 2003 Oct; 52 (10): 2636-2638. https://doi.org/10.2337/diabetes.52.10.2636

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KIR in Type 1 DiabetesDisparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects
Arno R. van der Slik, Bobby P.C. Koeleman, Willem Verduijn, G. Jan Bruining, Bart O. Roep and Marius J. Giphart

Diabetes 2003 Oct; 52 (10): 2639-2642. https://doi.org/10.2337/diabetes.52.10.2639

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Erratum

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Erratum
Diabetes 2003 Oct; 52 (10): 2643. https://doi.org/10.2337/diabetes.52.10.2643

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Table of Contents

Metabolism

Signal Transduction

Obesity Studies

Immunology and Transplantation

Islet Studies

Pathophysiology

Complications

Brief Genetics Reports

Erratum

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