Circulating Adiponectin Levels Are Reduced in Nonobese but Insulin-Resistant First-Degree Relatives of Type 2 Diabetic Patients
Article Figures & Tables
Tables
- TABLE 1
Basic characteristics, metabolic variables, lipoprotein concentrations, inflammatory markers, endothelial injury markers, and other markers in relatives and control subjects
Relatives Control subjects P Sex Male (n = 45) Male (n = 40) Age (years) 43.1 ± 8.6 45.1 ± 6.9 BMI (kg/m2) 25.8 ± 2.6 24.6 ± 2.6 <0.05 Waist circumference (cm) 94 ± 0.9 90 ± 0.9 <0.05 Body fat (kg) 19.5 ± 6.1 16.5 ± 6.6 <0.03 Blood pressure Systolic (mmHg) 128 ± 16 118 ± 9 <0.01 Diastolic (mmHg) 76 ± 6 73 ± 7 <0.05 Oral glucose tolerance test Fasting plasma proinsulin (pmol/l) 11 ± 7 9 ± 6 Fasting plasma glucose (mmol/l) 4.9 ± 0.5 4.4 ± 0.3 <0.0001 Fasting plasma insulin (pmol/l) 54 ± 24 48 ± 30 Plasma glucose at 120 min (mmol/l) 5.0 ± 1.2 4.0 ± 1.1 <0.0001 Plasma insulin at 120 min (pmol/l) 246 ± 174 168 ± 126 <0.05 Si (×10−4 × min−1 per μU/ml) 3.3 ± 2.4 4.5 ± 2.6 <0.01 Insulin secretion rate First-phase insulin response (0–10 min) (μU/min) 409 ± 305 412 ± 300 Lipoprotein concentration Fasting serum total cholesterol (mmol/l) 4.9 ± 0.9 4.4 ± 1.2 Fasting serum HDL cholesterol (mmol/l) 1.15 ± 0.23 1.15 ± 0.45 Fasting serum LDL cholesterol (mmol/l) 3.2 ± 0.8 2.7 ± 0.9 <0.01 Fasting serum triglyceride (mmol/l) 1.26 ± 0.60 1.37 ± 1.20 Fasting plasma free fatty acid (mmol/l) 0.48 ± 0.18 0.49 ± 0.23 LDL size (nm) 26.0 ± 1.22 26.0 ± 1.20 Inflammatory markers Serum C-reactive protein, (mg/l) 1.28 ± 2.04 0.76 ± 0.68 <0.1 Plasma fibrinogen (g/l) 2.55 ± 0.38 2.49 ± 0.52 Endothelial injury markers Serum VCAM-1 (ng/ml) 438 ± 72 462 ± 76 Serum ICAM-1 (ng/ml) 249 ± 50 233 ± 58 Serum E-selectin (ng/ml) 56.8 ± 19.6 51.2 ± 16.4 Other markers Serum adiponectin (μg/ml) 6.6 ± 1.8 8.1 ± 3.0 <0.03 Plasma PAI-1 (IU/ml) 19.4 ± 15.4 13.0 ± 14.7 <0.01 -
Data are mean ± SD. ICAM, intercellular adhesion molecule; VCAM, vascular cell adhesion molecule.
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- TABLE 2
Partial correlation coefficients (r) between adiponectin and selected variables in the relatives (n = 45)
Parameter Model 1 Model 2 Model 3 Fasting plasma insulin −0.55* −0.52* −0.43† Fasting plasma proinsulin −0.64* −0.61* −0.56* Si 0.41† 0.34‡ — Acute insulin response −0.40‡ −0.34† −0.26 HDL cholesterol 0.48† 0.43‡ 0.39‡ PAI-1 activity −0.56* −0.54* −0.53* -
Data are r. Model 1 is adjusted for age; model 2 is adjusted for age and waist; model 3 is adjusted for age, waist, and Si
- *
* P < 0.001;
- †
† P < 0.01;
- ‡
‡ P < 0.05.
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In this Issue
May 2003, 52(5)
Circulating Adiponectin Levels Are Reduced in Nonobese but Insulin-Resistant First-Degree Relatives of Type 2 Diabetic Patients
