Errata
Article Figures & Tables
Tables
- TABLE 3
Allele frequencies of CAPN10 SNPs in Finland
A. Marker Allele Botnia I Botnia II Pooled Type 2 diabetes Control subjects P Type 2 diabetes Control subjects P Type 2 diabetes Control subjects P SNP-44 1 (T) 293 (78.3) 288 (75.0) 0.28 327 (80.5) 173 (81.6) 0.75 620 (79.5) 461 (77.3) 0.34 2 (C) 81 (21.7) 96 (25.0) 79 (19.5) 39 (18.4) 160 (20.5) 135 (22.7) SNP-43 1 (G) 294 (76.6) 259 (67.4) 0.0049 301 (74.5) 153 (72.9) 0.66 595 (75.5) 412 (69.4) 0.011 2 (A) 90 (23.4) 125 (32.6) 103 (25.5) 57 (27.1) 193 (24.5) 182 (30.6) SNP-19 2 (ins) 217 (56.5) 236 (61.5) 0.16 229 (56.4) 112 (52.8) 0.40 446 (56.5) 348 (58.4) 0.47 1 (del) 167 (43.5) 148 (38.5) 177 (43.6) 100 (47.2) 344 (43.5) 248 (41.6) SNP-63 1 (C) 356 (92.7) 369 (96.6) 0.017 346 (85.2) 183 (86.3) 0.71 702 (88.9) 552 (92.9) 0.010 2 (T) 28 (7.3) 13 (3.4) 60 (14.8) 29 (13.7) 88 (11.1) 42 (7.1) -
Data are n (%). All SNPs were genotyped in 395 patients with type 2 diabetes and 298 control subjects. In all, 0.3% of the genotypes could not be provided despite repeated genotyping. Allele frequencies of SNP-43 and -44 did not significantly differ between Botnia I and II samples, whereas SNP-19 allele 1 was more common among control subjects from Botnia II compared with control subjects from Botnia I (47.2 vs. 38.5%; P = 0.041). The SNP-63 allele 2 was substantially more common among both type 2 diabetic patients and control subjects in Botnia II than in Botnia I (14.8 vs 7.3, [P = 0.00080] and 13.7 vs. 3.4% [P = 0.000013] for type 2 diabetic patients and control subjects in Botnia II and I, respectively). All genotype frequencies were in Hardy-Weinberg equilibrium, and those of SNP-43 and -63 differed significantly between type 2 diabetic patients and healthy control subjects (SNP-43: 57.6, 35.8, and 6.6 vs. 48.2, 42.4, and 9.4%; P = 0.039; SNP-63: 79.8, 18.2, and 2.0 vs. 87.2, 11.5, and 1.4%, P = 0.036 for genotypes 11, 12, and 22, respectively).
-