Promoter Polymorphisms of the TNF-α (G-308A) and IL-6 (C-174G) Genes Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The Finnish Diabetes Prevention Study

Agata Kubaszek; Jussi Pihlajamäki; Vladislav Komarovski; Virpi Lindi; Jaana Lindström; Johan Eriksson; Timo T. Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso

doi:10.2337/diabetes.52.7.1872

Brief Genetics Report

Promoter Polymorphisms of the TNF-α (G-308A) and IL-6 (C-174G) Genes Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes

The Finnish Diabetes Prevention Study

Agata Kubaszek1,
Jussi Pihlajamäki1,
Vladislav Komarovski1,
Virpi Lindi2,
Jaana Lindström3,
Johan Eriksson3,
Timo T. Valle3,
Helena Hämäläinen4,
Pirjo Ilanne-Parikka5,
Sirkka Keinänen-Kiukaanniemi6,
Jaakko Tuomilehto3 7,
Matti Uusitupa2 and
Markku Laakso1

¹Department of Medicine, University of Kuopio, Kuopio, Finland
²Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
³Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
⁴Research and Development Centre, Social Insurance Institution, Turku, Finland
⁵Department of Medicine, Finnish Diabetes Association and University of Tampere, Tampere, Finland
⁶Department of Public Health Science and General Practice, University of Oulu, Oulu University Hospital and Department of Sport Medicine, Oulu Deaconess Institute, Oulu, Finland
⁷Department of Public Health, University of Helsinki, Helsinki, Finland

Address correspondence and reprint requests to Markku Laakso, Professor and Chair, Department of Medicine, University of Kuopio, 70210 Kuopio, Finland. E-mail: markku.laakso{at}kuh.fi

Diabetes 2003 Jul; 52(7): 1872-1876. https://doi.org/10.2337/diabetes.52.7.1872

Article Information

vol. 52 no. 7 1872-1876

DOI

https://doi.org/10.2337/diabetes.52.7.1872

PubMed

12829659

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

April 8, 2003
February 9, 2003
Published in print July 1, 2003.

DIABETES

Author Information

Agata Kubaszek1,
Jussi Pihlajamäki1,
Vladislav Komarovski1,
Virpi Lindi2,
Jaana Lindström3,
Johan Eriksson3,
Timo T. Valle3,
Helena Hämäläinen4,
Pirjo Ilanne-Parikka5,
Sirkka Keinänen-Kiukaanniemi6,
Jaakko Tuomilehto3 7,
Matti Uusitupa2 and
Markku Laakso1

¹Department of Medicine, University of Kuopio, Kuopio, Finland
²Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
³Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
⁴Research and Development Centre, Social Insurance Institution, Turku, Finland
⁵Department of Medicine, Finnish Diabetes Association and University of Tampere, Tampere, Finland
⁶Department of Public Health Science and General Practice, University of Oulu, Oulu University Hospital and Department of Sport Medicine, Oulu Deaconess Institute, Oulu, Finland
⁷Department of Public Health, University of Helsinki, Helsinki, Finland

Address correspondence and reprint requests to Markku Laakso, Professor and Chair, Department of Medicine, University of Kuopio, 70210 Kuopio, Finland. E-mail: markku.laakso{at}kuh.fi

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: June 2003 to January 2021

Rendering graph...

	Abstract	Full	Pdf
Jun 2003	80	28	71
Jul 2003	81	170	216
Aug 2003	37	124	129
Sep 2003	37	154	132
Oct 2003	26	130	123
Nov 2003	24	92	79
Dec 2003	15	89	57
Jan 2004	13	72	52
Feb 2004	9	88	89
Mar 2004	18	79	74
Apr 2004	17	72	50
May 2004	39	95	36
Jun 2004	21	81	36
Jul 2004	28	71	46
Aug 2004	47	104	61
Sep 2004	44	92	53
Oct 2004	34	88	46
Nov 2004	23	89	47
Dec 2004	44	76	43
Jan 2005	30	80	52
Feb 2005	21	62	37
Mar 2005	23	65	32
Apr 2005	5	51	30
May 2005	7	36	33
Jun 2005	15	55	37
Jul 2005	9	50	26
Aug 2005	25	42	38
Sep 2005	11	44	35
Oct 2005	9	49	22
Nov 2005	14	53	46
Dec 2005	11	39	35
Jan 2006	13	35	15
Feb 2006	11	44	26
Mar 2006	5	41	22
Apr 2006	11	33	29
May 2006	9	42	28
Jun 2006	4	30	23
Jul 2006	4	28	17
Aug 2006	13	32	29
Sep 2006	17	29	34
Oct 2006	11	34	31
Nov 2006	13	36	20
Dec 2006	14	30	14
Jan 2007	11	26	16
Feb 2007	13	23	17
Mar 2007	21	45	27
Apr 2007	21	35	22
May 2007	19	47	20
Jun 2007	16	23	16
Jul 2007	18	22	20
Aug 2007	14	38	17
Sep 2007	12	25	19
Oct 2007	11	31	17
Nov 2007	19	22	12
Dec 2007	12	24	14
Jan 2008	12	32	19
Feb 2008	23	34	21
Mar 2008	50	23	20
Apr 2008	23	29	26
May 2008	18	28	17
Jun 2008	12	21	10
Jul 2008	29	41	26
Aug 2008	40	13	14
Sep 2008	80	16	17
Oct 2008	72	24	14
Nov 2008	16	34	22
Dec 2008	15	28	21
Jan 2009	3	22	21
Feb 2009	7	22	19
Mar 2009	27	21	11
Apr 2009	11	38	33
May 2009	7	13	15
Jun 2009	21	29	6
Jul 2009	26	26	16
Aug 2009	14	15	11
Sep 2009	38	18	13
Oct 2009	33	26	19
Nov 2009	20	22	14
Dec 2009	20	25	19
Jan 2010	15	25	8
Feb 2010	26	26	15
Mar 2010	6	42	17
Apr 2010	24	45	22
May 2010	30	67	22
Jun 2010	29	38	10
Jul 2010	17	39	21
Aug 2010	10	66	16
Sep 2010	7	50	21
Oct 2010	9	38	18
Nov 2010	23	51	18
Dec 2010	5	50	15
Jan 2011	12	40	17
Feb 2011	8	44	18
Mar 2011	15	50	28
Apr 2011	17	39	22
May 2011	29	23	18
Jun 2011	21	30	27
Jul 2011	23	18	27
Aug 2011	31	37	31
Sep 2011	26	31	18
Oct 2011	33	33	19
Nov 2011	34	37	23
Dec 2011	20	26	27
Jan 2012	17	33	24
Feb 2012	19	42	12
Mar 2012	31	47	26
Apr 2012	31	39	26
May 2012	29	26	27
Jun 2012	33	30	6
Jul 2012	29	35	24
Aug 2012	35	29	24
Sep 2012	30	35	27
Oct 2012	31	23	16
Nov 2012	30	21	21
Dec 2012	30	29	18
Jan 2013	35	41	15
Feb 2013	26	31	18
Mar 2013	30	17	12
Apr 2013	42	25	18
May 2013	38	30	29
Jun 2013	19	14	17
Jul 2013	13	20	14
Aug 2013	16	32	15
Sep 2013	17	13	13
Oct 2013	20	20	16
Nov 2013	18	14	12
Dec 2013	15	13	6
Jan 2014	25	27	12
Feb 2014	21	16	10
Mar 2014	33	29	18
Apr 2014	29	23	14
May 2014	28	27	11
Jun 2014	23	17	5
Jul 2014	46	38	14
Aug 2014	27	21	14
Sep 2014	17	21	16
Oct 2014	21	25	7
Nov 2014	14	22	12
Dec 2014	18	9	6
Jan 2015	19	14	7
Feb 2015	27	10	15
Mar 2015	28	22	14
Apr 2015	39	21	22
May 2015	23	18	21
Jun 2015	21	10	6
Jul 2015	16	13	9
Aug 2015	15	24	22
Sep 2015	46	12	7
Oct 2015	18	14	9
Nov 2015	21	22	17
Dec 2015	28	16	14
Jan 2016	27	11	6
Feb 2016	33	26	29
Mar 2016	11	26	10
Apr 2016	30	21	25
May 2016	15	33	22
Jun 2016	18	26	10
Jul 2016	6	16	8
Aug 2016	14	31	4
Sep 2016	11	39	13
Oct 2016	13	23	12
Nov 2016	14	40	19
Dec 2016	9	31	11
Jan 2017	12	26	10
Feb 2017	6	25	5
Mar 2017	2	31	14
Apr 2017	6	13	5
May 2017	10	28	10
Jun 2017	4	21	3
Jul 2017	7	21	5
Aug 2017	8	14	12
Sep 2017	7	15	6
Oct 2017	6	47	24
Nov 2017	4	33	27
Dec 2017	3	14	5
Jan 2018	6	23	5
Feb 2018	10	29	7
Mar 2018	4	16	4
Apr 2018	10	28	6
May 2018	4	32	7
Jun 2018	6	23	15
Jul 2018	7	21	12
Aug 2018	7	37	7
Sep 2018	4	78	19
Oct 2018	7	81	9
Nov 2018	11	77	15
Dec 2018	4	46	5
Jan 2019	8	41	7
Feb 2019	11	40	10
Mar 2019	3	22	8
Apr 2019	8	14	7
May 2019	7	15	9
Jun 2019	4	18	17
Jul 2019	3	12	7
Aug 2019	4	14	6
Sep 2019	9	50	10
Oct 2019	4	22	7
Nov 2019	11	23	9
Dec 2019	8	14	14
Jan 2020	6	12	6
Feb 2020	8	14	11
Mar 2020	0	22	8
Apr 2020	2	12	4
May 2020	3	18	9
Jun 2020	5	13	5
Jul 2020	1	8	5
Aug 2020	4	7	5
Sep 2020	7	14	9
Oct 2020	7	15	11
Nov 2020	13	41	19
Dec 2020	2	15	10
Jan 2021	5	14	11