Production of Nε-(Carboxymethyl)Lysine Is Impaired in Mice Deficient in NADPH Oxidase: A Role for Phagocyte-Derived Oxidants in the Formation of Advanced Glycation End Products During Inflammation

Melissa M. Anderson; Jay W. Heinecke

doi:10.2337/diabetes.52.8.2137

Complications

Production of N^ε-(Carboxymethyl)Lysine Is Impaired in Mice Deficient in NADPH Oxidase

A Role for Phagocyte-Derived Oxidants in the Formation of Advanced Glycation End Products During Inflammation

Melissa M. Anderson1 and
Jay W. Heinecke2

¹Pharmacia Corporation, St. Louis, Missouri
²Department of Medicine, University of Washington, Seattle, Washington

Address correspondence and reprint requests to Jay Heinecke, Division of Endocrinology, Metabolism and Nutrition, Box 356426, University of Washington, Seattle, WA 98195. E-mail: heinecke{at}u.washington.edu

Diabetes 2003 Aug; 52(8): 2137-2143. https://doi.org/10.2337/diabetes.52.8.2137

Article Information

vol. 52 no. 8 2137-2143

DOI

https://doi.org/10.2337/diabetes.52.8.2137

PubMed

12882933

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

May 12, 2003
April 15, 2003
Published in print July 25, 2003.

DIABETES

Author Information

Melissa M. Anderson1 and
Jay W. Heinecke2

¹Pharmacia Corporation, St. Louis, Missouri
²Department of Medicine, University of Washington, Seattle, Washington

Address correspondence and reprint requests to Jay Heinecke, Division of Endocrinology, Metabolism and Nutrition, Box 356426, University of Washington, Seattle, WA 98195. E-mail: heinecke{at}u.washington.edu

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: July 2003 to February 2021

Rendering graph...

	Abstract	Full	Pdf
Jul 2003	28	20	13
Aug 2003	43	87	47
Sep 2003	17	51	10
Oct 2003	18	38	14
Nov 2003	18	25	4
Dec 2003	24	23	10
Jan 2004	12	33	7
Feb 2004	16	35	5
Mar 2004	25	38	11
Apr 2004	15	52	33
May 2004	51	72	25
Jun 2004	17	50	25
Jul 2004	14	47	25
Aug 2004	40	61	14
Sep 2004	20	40	11
Oct 2004	19	45	8
Nov 2004	15	48	6
Dec 2004	21	37	20
Jan 2005	21	68	23
Feb 2005	19	32	7
Mar 2005	20	65	21
Apr 2005	3	23	10
May 2005	7	25	5
Jun 2005	5	32	20
Jul 2005	5	15	9
Aug 2005	9	13	4
Sep 2005	4	20	7
Oct 2005	6	17	5
Nov 2005	6	22	7
Dec 2005	5	19	6
Jan 2006	8	21	8
Feb 2006	6	35	13
Mar 2006	6	31	7
Apr 2006	5	29	5
May 2006	2	27	5
Jun 2006	4	34	7
Jul 2006	2	31	5
Aug 2006	2	27	3
Sep 2006	4	33	6
Oct 2006	2	26	7
Nov 2006	2	47	5
Dec 2006	8	34	7
Jan 2007	4	35	12
Feb 2007	3	33	6
Mar 2007	4	38	15
Apr 2007	9	32	7
May 2007	3	37	12
Jun 2007	9	27	8
Jul 2007	8	31	7
Aug 2007	1	26	12
Sep 2007	1	22	5
Oct 2007	3	22	5
Nov 2007	6	22	5
Dec 2007	1	20	3
Jan 2008	6	25	7
Feb 2008	3	25	8
Mar 2008	11	29	12
Apr 2008	5	19	11
May 2008	9	23	5
Jun 2008	3	49	9
Jul 2008	5	46	6
Aug 2008	18	66	8
Sep 2008	8	38	9
Oct 2008	12	37	8
Nov 2008	13	31	8
Dec 2008	11	46	13
Jan 2009	13	48	4
Feb 2009	3	45	9
Mar 2009	17	39	4
Apr 2009	5	32	5
May 2009	5	27	2
Jun 2009	18	7	7
Jul 2009	20	10	4
Aug 2009	12	9	10
Sep 2009	14	6	2
Oct 2009	20	4	3
Nov 2009	14	12	11
Dec 2009	9	8	12
Jan 2010	7	3	4
Feb 2010	15	1	12
Mar 2010	13	13	15
Apr 2010	6	15	9
May 2010	9	6	10
Jun 2010	3	11	6
Jul 2010	11	12	16
Aug 2010	3	10	5
Sep 2010	6	7	5
Oct 2010	13	31	18
Nov 2010	7	30	5
Dec 2010	9	34	7
Jan 2011	8	28	7
Feb 2011	7	33	11
Mar 2011	6	32	15
Apr 2011	7	27	10
May 2011	11	31	17
Jun 2011	12	31	7
Jul 2011	12	44	12
Aug 2011	24	36	29
Sep 2011	15	51	40
Oct 2011	20	37	21
Nov 2011	26	39	15
Dec 2011	29	35	18
Jan 2012	13	29	14
Feb 2012	12	26	15
Mar 2012	21	25	20
Apr 2012	10	30	9
May 2012	27	28	24
Jun 2012	14	14	10
Jul 2012	16	22	14
Aug 2012	21	20	11
Sep 2012	31	22	11
Oct 2012	16	11	16
Nov 2012	19	30	16
Dec 2012	23	32	16
Jan 2013	15	39	13
Feb 2013	20	27	7
Mar 2013	18	24	8
Apr 2013	15	39	12
May 2013	23	20	9
Jun 2013	8	9	0
Jul 2013	6	12	7
Aug 2013	6	16	10
Sep 2013	7	8	3
Oct 2013	10	7	4
Nov 2013	7	16	4
Dec 2013	17	15	1
Jan 2014	14	21	12
Feb 2014	10	15	1
Mar 2014	6	21	5
Apr 2014	16	33	9
May 2014	10	32	11
Jun 2014	16	29	10
Jul 2014	25	37	7
Aug 2014	8	21	8
Sep 2014	5	22	8
Oct 2014	7	21	10
Nov 2014	16	15	4
Dec 2014	9	19	0
Jan 2015	16	15	8
Feb 2015	16	10	8
Mar 2015	13	24	12
Apr 2015	9	12	4
May 2015	12	33	4
Jun 2015	8	26	4
Jul 2015	13	21	7
Aug 2015	12	17	5
Sep 2015	21	14	2
Oct 2015	5	10	0
Nov 2015	6	16	3
Dec 2015	17	21	6
Jan 2016	14	28	6
Feb 2016	6	21	4
Mar 2016	7	9	8
Apr 2016	14	12	14
May 2016	5	19	16
Jun 2016	2	19	14
Jul 2016	3	13	6
Aug 2016	2	19	9
Sep 2016	3	12	4
Oct 2016	7	24	9
Nov 2016	0	15	8
Dec 2016	3	24	4
Jan 2017	6	12	3
Feb 2017	2	9	3
Mar 2017	3	24	4
Apr 2017	3	12	0
May 2017	1	33	7
Jun 2017	1	19	0
Jul 2017	1	45	1
Aug 2017	0	36	1
Sep 2017	0	30	3
Oct 2017	4	28	13
Nov 2017	1	34	8
Dec 2017	1	7	4
Jan 2018	1	12	7
Feb 2018	2	16	12
Mar 2018	0	24	6
Apr 2018	0	24	4
May 2018	2	31	3
Jun 2018	1	25	3
Jul 2018	1	20	6
Aug 2018	1	19	2
Sep 2018	2	23	3
Oct 2018	0	33	3
Nov 2018	2	29	8
Dec 2018	0	17	2
Jan 2019	2	31	14
Feb 2019	3	19	13
Mar 2019	3	20	16
Apr 2019	4	13	13
May 2019	2	16	17
Jun 2019	7	13	11
Jul 2019	0	11	12
Aug 2019	2	14	11
Sep 2019	1	10	7
Oct 2019	0	13	7
Nov 2019	1	13	6
Dec 2019	1	22	7
Jan 2020	1	12	4
Feb 2020	2	9	4
Mar 2020	1	14	3
Apr 2020	1	12	2
May 2020	1	17	7
Jun 2020	3	6	2
Jul 2020	2	9	3
Aug 2020	0	11	7
Sep 2020	3	33	8
Oct 2020	0	20	9
Nov 2020	6	18	11
Dec 2020	1	18	11
Jan 2021	1	16	7
Feb 2021	1	10	3