A Novel Insulin Analog With Unique Properties: LysB3,GluB29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1

Irini Rakatzi; Stefanie Ramrath; Daniela Ledwig; Olaf Dransfeld; Thomas Bartels; Gerhard Seipke; Jürgen Eckel

doi:10.2337/diabetes.52.9.2227

Signal Transduction

A Novel Insulin Analog With Unique Properties

Lys^B3,Glu^B29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1

Irini Rakatzi1,
Stefanie Ramrath1,
Daniela Ledwig1,
Olaf Dransfeld1,
Thomas Bartels2,
Gerhard Seipke2 and
Jürgen Eckel1

¹Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Research Institute, Düsseldorf, Germany
²Aventis Pharma GmbH, Frankfurt, Germany

Address correspondence and reprint requests to Prof. Dr. Jürgen Eckel, German Diabetes Research Institute, Auf’m Hennekamp 65, D-40225 Düsseldorf, Germany. E-mail: eckel{at}uni-duesseldorf.de

Diabetes 2003 Sep; 52(9): 2227-2238. https://doi.org/10.2337/diabetes.52.9.2227

Article Information

vol. 52 no. 9 2227-2238

DOI

https://doi.org/10.2337/diabetes.52.9.2227

PubMed

12941761

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

June 5, 2003
October 8, 2002
Published in print August 26, 2003.

DIABETES

Author Information

Irini Rakatzi1,
Stefanie Ramrath1,
Daniela Ledwig1,
Olaf Dransfeld1,
Thomas Bartels2,
Gerhard Seipke2 and
Jürgen Eckel1

¹Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Research Institute, Düsseldorf, Germany
²Aventis Pharma GmbH, Frankfurt, Germany

Address correspondence and reprint requests to Prof. Dr. Jürgen Eckel, German Diabetes Research Institute, Auf’m Hennekamp 65, D-40225 Düsseldorf, Germany. E-mail: eckel{at}uni-duesseldorf.de

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