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OtherComplications

Glycation Inactivation of the Complement Regulatory Protein CD59

A Possible Role in the Pathogenesis of the Vascular Complications of Human Diabetes

Xuebin Qin, Allison Goldfine, Nicole Krumrei, Luciano Grubissich, Juan Acosta, Michael Chorev, Arthur P. Hays, Jose A. Halperin
DOI: 10.2337/diabetes.53.10.2653 Published 1 October 2004
Xuebin Qin
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Allison Goldfine
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Nicole Krumrei
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Luciano Grubissich
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Juan Acosta
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Michael Chorev
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Arthur P. Hays
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Jose A. Halperin
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FIG. 3.

FIG. 3.
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FIG. 3.

Glycated hCD59 colocalizes with MAC in diabetic human kidneys. Serial sections of the same glomerulus in a diabetic (D) and nondiabetic (ND) kidney stained with anti-MAC or anti–glycated hCD59 antibodies. The arrows indicate positive staining areas for glycated CD59 and MAC in the same glomerulus. (The minor distortion in the anatomy of the glomeruli shown is due to the different planes of the serial sections and the incubation with sodium borohydride before staining with anti–glycated hCD59.) Magnification ×20.

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