Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism
The San Antonio Family Heart Study
Article Figures & Tables
Figures
- FIG. 1.
The multipoint analyses of insulin response to glucose index (IRG) and the abdominal skinfold average (ABDOM) on chromosome 8.
- FIG. 2.
The multipoint analysis of correct insulin response to glucose index (CIR) on chromosome 13.
Tables
- TABLE 1
Relative pairs in this study
Relative relationship Size Parent-offspring 403 Siblings 450 Grandparent-grandchild 308 Avuncular 717 Half-siblings 104 Great grandparent–grandchild 92 Grand avuncular 231 Half avuncular 114 First cousins 882 First cousins, once removed 634 First cousins, twice removed 65 Half first cousins 62 Second cousins 190 Total 4,252 - TABLE 2
Characteristics of study population
Trait Mean Size h2* Fasting glucose (mg/dl) 85.76 ± 10.11 818 0.24 ± 0.05 2-h glucose (mg/dl) 97.5 ± 29.99 765 0.27 ± 0.06 Fasting insulin (units/ml)† 11.8 ± 7.4 767 0.32 ± 0.07 2-h insulin (units/ml)† 68.78 ± 56.53 771 0.34 ± 0.07 QUICKI × 100 16.85 ± 0.93 809 0.40 ± 0.06 IRG† 132.45 ± 649.45 819 0.13 ± 0.08 CIR† 0.0165 ± 0.4208 631 0.30 ± 0.07 HOMA-IR† 2.84 ± 2.16 789 0.39 ± 0.06 ABDOM (mm) 41.2 ± 13.9 961 0.38 ± 0.07 Data are means ± SD.
- *
* P < 0.05;
- †
† logarithm transformed. ABDOM, abdominal skinfold average.
- TABLE 3
Genome scan results with LOD >1.86 or repeat signal (LOD >1.30)
Chromosome nearest marker Trait LOD score 8 D8S1130-D8S1106 (22–26 cM) IRG* 3.09 D8S1106 (26 cM) ABDOM 2.68 9 D9S301 (66 cM) Fasting glucose 2.19 12 D12S1090 (56 cM) IRG* 1.9 D12S395-D12S1045 (137–161 cM) CIR* 2.24 13 D13S787-D13S252 (9–16 cM) CIR* 2.98 D13S285 (111 cM) HOMA IR* 1.35 D13S285 (111 cM) QUICKI 1.86 18 D18S858 (80 cM) 2-h insulin* 1.87 - *
* Logarithm transformed.
- *
In this Issue
May 2004, 53(5)
Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism
