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Genetics

Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism

The San Antonio Family Heart Study

  1. Guowen Cai12,
  2. Shelley A. Cole1,
  3. Jeanne H. Freeland-Graves2,
  4. Jean W. MacCluer1,
  5. John Blangero1 and
  6. Anthony G. Comuzzie1
  1. 1Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
  2. 2Department of Human Ecology, Nutrition Division, University of Texas at Austin, Austin, Texas
  1. Address correspondence and reprint requests to Anthony G. Comuzzie, Department of Genetics Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227-5301. E-mail: agcom{at}darwin.sfbr.org
Diabetes 2004 May; 53(5): 1369-1374. https://doi.org/10.2337/diabetes.53.5.1369
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  • FIG. 1.
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    FIG. 1.

    The multipoint analyses of insulin response to glucose index (IRG) and the abdominal skinfold average (ABDOM) on chromosome 8.

  • FIG. 2.
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    FIG. 2.

    The multipoint analysis of correct insulin response to glucose index (CIR) on chromosome 13.

Tables

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  • TABLE 1

    Relative pairs in this study

    Relative relationshipSize
    Parent-offspring403
    Siblings450
    Grandparent-grandchild308
    Avuncular717
    Half-siblings104
    Great grandparent–grandchild92
    Grand avuncular231
    Half avuncular114
    First cousins882
    First cousins, once removed634
    First cousins, twice removed65
    Half first cousins62
    Second cousins190
    Total4,252
  • TABLE 2

    Characteristics of study population

    TraitMeanSizeh2*
    Fasting glucose (mg/dl)85.76 ± 10.118180.24 ± 0.05
    2-h glucose (mg/dl)97.5 ± 29.997650.27 ± 0.06
    Fasting insulin (units/ml)†11.8 ± 7.47670.32 ± 0.07
    2-h insulin (units/ml)†68.78 ± 56.537710.34 ± 0.07
    QUICKI × 10016.85 ± 0.938090.40 ± 0.06
    IRG†132.45 ± 649.458190.13 ± 0.08
    CIR†0.0165 ± 0.42086310.30 ± 0.07
    HOMA-IR†2.84 ± 2.167890.39 ± 0.06
    ABDOM (mm)41.2 ± 13.99610.38 ± 0.07
    • Data are means ± SD.

    • *

      * P < 0.05;

    • †

      † logarithm transformed. ABDOM, abdominal skinfold average.

  • TABLE 3

    Genome scan results with LOD >1.86 or repeat signal (LOD >1.30)

    Chromosome nearest markerTraitLOD score
    8D8S1130-D8S1106 (22–26 cM)IRG*3.09
    D8S1106 (26 cM)ABDOM2.68
    9D9S301 (66 cM)Fasting glucose2.19
    12D12S1090 (56 cM)IRG*1.9
    D12S395-D12S1045 (137–161 cM)CIR*2.24
    13D13S787-D13S252 (9–16 cM)CIR*2.98
    D13S285 (111 cM)HOMA IR*1.35
    D13S285 (111 cM)QUICKI1.86
    18D18S858 (80 cM)2-h insulin*1.87
    • *

      * Logarithm transformed.

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Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism
Guowen Cai, Shelley A. Cole, Jeanne H. Freeland-Graves, Jean W. MacCluer, John Blangero, Anthony G. Comuzzie
Diabetes May 2004, 53 (5) 1369-1374; DOI: 10.2337/diabetes.53.5.1369

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Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism
Guowen Cai, Shelley A. Cole, Jeanne H. Freeland-Graves, Jean W. MacCluer, John Blangero, Anthony G. Comuzzie
Diabetes May 2004, 53 (5) 1369-1374; DOI: 10.2337/diabetes.53.5.1369
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