Diabetes: 53 (6)

June 01 2004; volume 53 issue 6

Rapid Publication

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Human Pancreatic Duct Cells Exert Tissue Factor-Dependent Procoagulant ActivityRelevance to Islet Transplantation
Claire Beuneu, Olivier Vosters, Babak Movahedi, Myriam Remmelink, Isabelle Salmon, Daniel Pipeleers, Olivier Pradier, Michel Goldman and Valérie Verhasselt

Diabetes 2004 Jun; 53 (6): 1407-1411. https://doi.org/10.2337/diabetes.53.6.1407

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Perspective in Diabetes

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Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes
Patrick Schrauwen and Matthijs K.C. Hesselink

Diabetes 2004 Jun; 53 (6): 1412-1417. https://doi.org/10.2337/diabetes.53.6.1412

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Metabolism

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Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo
Michelle A. Vincent, Lucy H. Clerk, Jonathan R. Lindner, Alexander L. Klibanov, Michael G. Clark, Stephen Rattigan and Eugene J. Barrett

Diabetes 2004 Jun; 53 (6): 1418-1423. https://doi.org/10.2337/diabetes.53.6.1418

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Relationship Between Serum Amyloid A Level and Tanis/SelS mRNA Expression in Skeletal Muscle and Adipose Tissue From Healthy and Type 2 Diabetic Subjects
Håkan K.R. Karlsson, Hiroki Tsuchida, Staffan Lake, Heikki A. Koistinen and Anna Krook

Diabetes 2004 Jun; 53 (6): 1424-1428. https://doi.org/10.2337/diabetes.53.6.1424

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Signal Transduction

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AMP Kinase-Induced Skeletal Muscle Glucose But Not Long-Chain Fatty Acid Uptake Is Dependent on Nitric Oxide
Jane Shearer, Patrick T. Fueger, Brittney Vorndick, Deanna P. Bracy, Jeffery N. Rottman, Jeffery A. Clanton and David H. Wasserman

Diabetes 2004 Jun; 53 (6): 1429-1435. https://doi.org/10.2337/diabetes.53.6.1429

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Effects of Insulin, Contraction, and Phorbol Esters on Mitogen-Activated Protein Kinase Signaling in Skeletal Muscle From Lean and ob/ob Mice
Ying Leng, Tatiana L. Steiler and Juleen R. Zierath

Diabetes 2004 Jun; 53 (6): 1436-1444. https://doi.org/10.2337/diabetes.53.6.1436

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Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1
Hubert C. Chen, Meghana Rao, Mini P. Sajan, Mary Standaert, Yoshinori Kanoh, Atsushi Miura, Robert V. Farese and Robert V. Farese

Diabetes 2004 Jun; 53 (6): 1445-1451. https://doi.org/10.2337/diabetes.53.6.1445

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Immunology and Transplantation

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Advanced Glycation End Products Modulate the Maturation and Function of Peripheral Blood Dendritic Cells
Claire L. Price, Patrick S. Sharp, Margaret E. North, Sandra J. Rainbow and Stella C. Knight

Diabetes 2004 Jun; 53 (6): 1452-1458. https://doi.org/10.2337/diabetes.53.6.1452

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Tracking the Recruitment of Diabetogenic CD8⁺ T-Cells to the Pancreas in Real Time
Anna Moore, Jan Grimm, Bingye Han and Pere Santamaria

Diabetes 2004 Jun; 53 (6): 1459-1466. https://doi.org/10.2337/diabetes.53.6.1459

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Islet Study

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Changes in the Dimeric State of Neuronal Nitric Oxide Synthase Affect the Kinetics of Secretagogue-Induced Insulin Response
Anne-Dominique Lajoix, Martine Pugnière, Françoise Roquet, Jean-Claude Mani, Samuel Dietz, Nathalie Linck, Fleur Faurie, Gérard Ribes, Pierre Petit and René Gross

Diabetes 2004 Jun; 53 (6): 1467-1474. https://doi.org/10.2337/diabetes.53.6.1467

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The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade in Glucose Upregulation of Insulin Gene Expression
Xiao Yu, Koji Murao, Yoshitaka Sayo, Hitomi Imachi, Wen M. Cao, Shouji Ohtsuka, Michio Niimi, Hiroshi Tokumitsu, Hiroyuki Inuzuka, Norman C.W. Wong, Ryoji Kobayashi and Toshihiko Ishida

Diabetes 2004 Jun; 53 (6): 1475-1481. https://doi.org/10.2337/diabetes.53.6.1475

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Regulation of α-Cell Function by the β-Cell During Hypoglycemia in Wistar Rats: the “Switch-off” Hypothesis
Huarong Zhou, Phuong Oanh T. Tran, Shilin Yang, Tao Zhang, Eric LeRoy, Elizabeth Oseid and R. Paul Robertson

Diabetes 2004 Jun; 53 (6): 1482-1487. https://doi.org/10.2337/diabetes.53.6.1482

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Regulation of α-Cell Function by the β-Cell in Isolated Human and Rat Islets Deprived of Glucose: the “Switch-off” Hypothesis
Kristine M. Hope, Phuong Oanh T. Tran, Huarong Zhou, Elizabeth Oseid, Eric Leroy and R. Paul Robertson

Diabetes 2004 Jun; 53 (6): 1488-1495. https://doi.org/10.2337/diabetes.53.6.1488

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Glucose and Insulin Treatment of Insulinoma Cells Results in Transcriptional Regulation of a Common Set of Genes
Mitsuru Ohsugi, Corentin Cras-Méneur, Yiyong Zhou, Wesley Warren, Ernesto Bernal-Mizrachi and M. Alan Permutt

Diabetes 2004 Jun; 53 (6): 1496-1508. https://doi.org/10.2337/diabetes.53.6.1496

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Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat)A New Model for Type 2 Diabetes
Alexandra E. Butler, Jennifer Jang, Tatyana Gurlo, Maynard D. Carty, Walter C. Soeller and Peter C. Butler

Diabetes 2004 Jun; 53 (6): 1509-1516. https://doi.org/10.2337/diabetes.53.6.1509

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Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca²⁺-ATPase (SERCA)-2b and -3
Rohit N. Kulkarni, Michael G. Roper, Gabriella Dahlgren, David Q. Shih, Lisa M. Kauri, Jennifer L. Peters, Markus Stoffel and Robert T. Kennedy

Diabetes 2004 Jun; 53 (6): 1517-1525. https://doi.org/10.2337/diabetes.53.6.1517

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Regulation of Rat Pancreatic CCK_B Receptor and Somatostatin Expression by Insulin
Sophie Julien, Jean Laine and Jean Morisset

Diabetes 2004 Jun; 53 (6): 1526-1534. https://doi.org/10.2337/diabetes.53.6.1526

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Pathophysiology

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Influence of Autonomic Neuropathy on QTc Interval Lengthening During Hypoglycemia in Type 1 Diabetes
Stuart P. Lee, Lishan Yeoh, Nigel D. Harris, Catherine M. Davies, Robert T. Robinson, Andrew Leathard, Christopher Newman, Ian A. Macdonald and Simon R. Heller

Diabetes 2004 Jun; 53 (6): 1535-1542. https://doi.org/10.2337/diabetes.53.6.1535

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Muscle Strength in Type 2 Diabetes
Henning Andersen, Søren Nielsen, Carl E. Mogensen and Johannes Jakobsen

Diabetes 2004 Jun; 53 (6): 1543-1548. https://doi.org/10.2337/diabetes.53.6.1543

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Differences in Insulin Resistance in Nondiabetic Subjects With Isolated Impaired Glucose Tolerance or Isolated Impaired Fasting Glucose
Andreas Festa, Ralph D’Agostino, Anthony J.G. Hanley, Andrew J. Karter, Mohammed F. Saad and Steven M. Haffner

Diabetes 2004 Jun; 53 (6): 1549-1555. https://doi.org/10.2337/diabetes.53.6.1549

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Complication

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Molecular Alterations Underlie Nodal and Paranodal Degeneration in Type 1 Diabetic Neuropathy and Are Prevented by C-Peptide
Anders A.F. Sima, Weixian Zhang, Zhen-Guo Li, Yuichi Murakawa and Christopher R. Pierson

Diabetes 2004 Jun; 53 (6): 1556-1563. https://doi.org/10.2337/diabetes.53.6.1556

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Early Endothelial Dysfunction Severely Impairs Skin Blood Flow Response to Local Pressure Application in Streptozotocin-Induced Diabetic Mice
Dominique Sigaudo-Roussel, Claire Demiot, Bérengère Fromy, Audrey Koïtka, Georges Lefthériotis, Pierre Abraham and Jean Louis Saumet

Diabetes 2004 Jun; 53 (6): 1564-1569. https://doi.org/10.2337/diabetes.53.6.1564

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Association Between Mannose-Binding Lectin and Vascular Complications in Type 1 Diabetes
Troels K. Hansen, Lise Tarnow, Steffen Thiel, Rudi Steffensen, Coen D. Stehouwer, Casper G. Schalkwijk, Hans-Henrik Parving and Allan Flyvbjerg

Diabetes 2004 Jun; 53 (6): 1570-1576. https://doi.org/10.2337/diabetes.53.6.1570

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Genetics

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A New Mouse Model of Type 2 Diabetes, Produced by N-Ethyl-Nitrosourea Mutagenesis, Is the Result of a Missense Mutation in the Glucokinase Gene
Ayo A. Toye, Lee Moir, Alison Hugill, Liz Bentley, Julie Quarterman, Vesna Mijat, Tertius Hough, Michelle Goldsworthy, Alison Haynes, A. Jacqueline Hunter, Mick Browne, Nigel Spurr and Roger D. Cox

Diabetes 2004 Jun; 53 (6): 1577-1583. https://doi.org/10.2337/diabetes.53.6.1577

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Interaction and Association Analysis of a Type 1 Diabetes Susceptibility Locus on Chromosome 5q11-q13 and the 7q32 Chromosomal Region in Scandinavian Families
Pernilla Holm, Berit Rydlander, Holger Luthman and Ingrid Kockum

Diabetes 2004 Jun; 53 (6): 1584-1591. https://doi.org/10.2337/diabetes.53.6.1584

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A Novel Syndrome of Autosomal-Dominant Hyperinsulinemic Hypoglycemia Linked to a Mutation in the Human Insulin Receptor Gene
Kurt Højlund, Torben Hansen, Maria Lajer, Jan Erik Henriksen, Klaus Levin, Jörgen Lindholm, Oluf Pedersen and Henning Beck-Nielsen

Diabetes 2004 Jun; 53 (6): 1592-1598. https://doi.org/10.2337/diabetes.53.6.1592

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Brief Genetics Report

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Diabetes-Associated Mutations in Insulin Identify Invariant Receptor Contacts
Bin Xu, Shi-Quan Hu, Ying-Chi Chu, Shuhua Wang, Run-ying Wang, Satoe H. Nakagawa, Panayotis G. Katsoyannis and Michael A. Weiss

Diabetes 2004 Jun; 53 (6): 1599-1602. https://doi.org/10.2337/diabetes.53.6.1599

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Leptin and Leptin Receptor Gene Polymorphisms and Changes in Glucose Homeostasis in Response to Regular Exercise in Nondiabetic IndividualsThe HERITAGE Family Study
Timo A. Lakka, Tuomo Rankinen, S. John Weisnagel, Yvon C. Chagnon, Hanna-Maaria Lakka, Olavi Ukkola, Normand Boulé, Treva Rice, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, D.C. Rao, Richard Bergman and Claude Bouchard

Diabetes 2004 Jun; 53 (6): 1603-1608. https://doi.org/10.2337/diabetes.53.6.1603

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Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25
Maggie C.Y. Ng, Wing-Yee So, Nancy J. Cox, Vincent K.L. Lam, Clive S. Cockram, Julian A.J.H. Critchley, Graeme I. Bell and Juliana C.N. Chan

Diabetes 2004 Jun; 53 (6): 1609-1613. https://doi.org/10.2337/diabetes.53.6.1609

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Pharmacology and Therapeutics

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Lower Within-Subject Variability of Insulin Detemir in Comparison to NPH Insulin and Insulin Glargine in People With Type 1 Diabetes
Tim Heise, Leszek Nosek, Birgitte Biilmann Rønn, Lars Endahl, Lutz Heinemann, Christoph Kapitza and Eberhard Draeger

Diabetes 2004 Jun; 53 (6): 1614-1620. https://doi.org/10.2337/diabetes.53.6.1614

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Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes
Julia Tonelli, Weijie Li, Preeti Kishore, Utpal B. Pajvani, Elize Kwon, Charles Weaver, Philipp E. Scherer and Meredith Hawkins

Diabetes 2004 Jun; 53 (6): 1621-1629. https://doi.org/10.2337/diabetes.53.6.1621

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Table of Contents

Rapid Publication

Perspective in Diabetes

Metabolism

Signal Transduction

Immunology and Transplantation

Islet Study

Pathophysiology

Complication

Genetics

Brief Genetics Report

Pharmacology and Therapeutics

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