Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25

Brief Genetics Report

¹Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
²Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois
³Department of Human Genetics, University of Chicago, Chicago, Illinois
⁴Department of Medicine, University of Chicago, Chicago, Illinois

Address correspondence and reprint requests to Dr. Maggie C.Y. Ng, Howard Hughes Medical Institute, University of Chicago, 5841 S. Maryland Ave., MC1028, Chicago, IL 60637. E-mail: maggieng{at}uchicago.edu

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FIG. 1.
Multipoint linkage analyses for diabetes and glucose intolerance. The horizontal axis is centimorgans from the p-terminus.

TABLE 1

Regions showing nominal evidence of linkage to type 2 diabetes in Hong Kong Chinese*

Chromosome	Flanking markers	Position (cM)†	LOD	P_pointwise
1	APOA2-D1S194	173.9	3.09	0.00008
3	D3S4545	26.3	1.27	0.008
4	D4S2394-D4S1644	135.3	2.63	0.0003
5	D5S816	139.3	0.84	0.02
6	D6S1277-D6S1027	178.9	1.91	0.002
12	D12S1042	48.7	1.99	0.0012
18	D18S843	28.1	1.00	0.02

*
* Evidence of linkage is determined as LOD >0.59, P_pointwise < 0.05;
†
† marker positions are indicated in Haldane centimorgans from the p-terminus obtained from the Marshfield Medical Research Foundation.

TABLE 2

Regions showing nominal evidence for linkage with type 2 diabetes in Hong Kong Chinese and their replications in other studies

Chromosome	Location (cM from pter)	Study/trait (reference)
1	173.9	Chinese (Shanghai)/young-onset GIT (12)
		Old Order Amish/GIT (13)
		Caucasian (Utah)/type 2 diabetes (2–4)
		Pima Indian/young-onset type 2 diabetes (10)
		Caucasian (U.K.)/type 2 diabetes (11)
		Caucasian (France)/lean type 2 diabetes (14)
		Caucasian (Framingham)/HbA_1c (4)
3	26.3	Caucasian (Scandinavian)/young-onset type 2 diabetes (26)
4	135.3	Old Order Amish/GIT (13)
5	139.3	Chinese (Shanghai)/GIT (12)
		Caucasian (Finland/Sweden)/young-onset type 2 diabetes (27)
6	178.9	African American/type 2 diabetes (28)
12	48.7	Caucasian (France)/young-onset GIT (14)
18	28.1	Chinese (Shanghai)/GIT (12)
		Caucasian (Finland/Sweden)/obese type 2 diabetes (27)
		Caucasian (Netherlands)/obese type 2 diabetes (29)