Diabetes: 53 (suppl 1)

Novel Factors in the Regulation of Beta-Cell Function

February 01 2004; volume 53 issue suppl 1

Editorial

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EditorialNovel Factors in the Regulation of β-Cell Function
Christian Boitard, Erol Cerasi, Suad Efendic, Jean-Claude Henquin, Donald F. Steiner and Ele Ferrannini

Diabetes 2004 Feb; 53 (suppl 1): S1-S3. https://doi.org/10.2337/diabetes.53.2007.S1

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Section I: Genetic Factors in Type 2 Diabetes -- In Search of New Links

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Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 Diabetes
Edward H. Leiter and Peter C. Reifsnyder

Diabetes 2004 Feb; 53 (suppl 1): S4-S11. https://doi.org/10.2337/diabetes.53.2007.S4

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Structure, Activation, and Biology of Calpain
Koichi Suzuki, Shoji Hata, Yukiko Kawabata and Hiroyuki Sorimachi

Diabetes 2004 Feb; 53 (suppl 1): S12-S18. https://doi.org/10.2337/diabetes.53.2007.S12

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Linkage of Calpain 10 to Type 2 DiabetesThe Biological Rationale
Nancy J. Cox, M. Geoffrey Hayes, Cheryl A. Roe, Takafumi Tsuchiya and Graeme I. Bell

Diabetes 2004 Feb; 53 (suppl 1): S19-S25. https://doi.org/10.2337/diabetes.53.2007.S19

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Genetic Factors and Insulin SecretionGene Variants in the IGF Genes
Leen M. ’t Hart, Andreas Fritsche, Ingrid Rietveld, Jacqueline M. Dekker, Giel Nijpels, Fausto Machicao, Michael Stumvoll, Cornelia M. van Duijn, Hans U. Häring, Robert J. Heine, J. Antonie Maassen and Timon W. van Haeften

Diabetes 2004 Feb; 53 (suppl 1): S26-S30. https://doi.org/10.2337/diabetes.53.2007.S26

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Single Nucleotide Polymorphisms in the Proximal Promoter Region of the Adiponectin (APM1) Gene Are Associated With Type 2 Diabetes in Swedish Caucasians
Harvest F. Gu, Adili Abulaiti, Claes-Göran Östenson, Keith Humphreys, Claes Wahlestedt, Anthony J. Brookes and Suad Efendic

Diabetes 2004 Feb; 53 (suppl 1): S31-S35. https://doi.org/10.2337/diabetes.53.2007.S31

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Section II: Nuclear Receptors and Islet Function

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Putative Metabolic Effects of the Liver X Receptor (LXR)
Knut R. Steffensen and Jan-Åke Gustafsson

Diabetes 2004 Feb; 53 (suppl 1): S36-S42. https://doi.org/10.2337/diabetes.53.2007.S36

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The Biology of Peroxisome Proliferator-Activated ReceptorsRelationship With Lipid Metabolism and Insulin Sensitivity
Pascal Ferré

Diabetes 2004 Feb; 53 (suppl 1): S43-S50. https://doi.org/10.2337/diabetes.53.2007.S43

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Aged Transgenic Mice With Increased Glucocorticoid Sensitivity in Pancreatic β-Cells Develop Diabetes
Behrous Davani, Neil Portwood, Galina Bryzgalova, Martina Kvist Reimer, Thomas Heiden, Claes-Göran Östenson, Sam Okret, Bo Ahren, Suad Efendic and Akhtar Khan

Diabetes 2004 Feb; 53 (suppl 1): S51-S59. https://doi.org/10.2337/diabetes.53.2007.S51

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Role of Peroxisome Proliferator-Activated Receptor-γ in the Glucose-Sensing Apparatus of Liver and β-Cells
Ha-il Kim and Yong-ho Ahn

Diabetes 2004 Feb; 53 (suppl 1): S60-S65. https://doi.org/10.2337/diabetes.53.2007.S60

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Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ
So-youn Kim, Ha-il Kim, Sang-Kyu Park, Seung-Soon Im, Tianzhu Li, Hyae Gyeong Cheon and Yong-ho Ahn

Diabetes 2004 Feb; 53 (suppl 1): S66-S70. https://doi.org/10.2337/diabetes.53.2007.S66

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Potential Role of Peroxisome Proliferator-Activated Receptor-α in the Modulation of Glucose-Stimulated Insulin Secretion
Mary C. Sugden and Mark J. Holness

Diabetes 2004 Feb; 53 (suppl 1): S71-S81. https://doi.org/10.2337/diabetes.53.2007.S71

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Nuclear Protein p8 Is Associated With Glucose-Induced Pancreatic β-Cell Growth
Günter Päth, Anne Opel, Anita Knoll and Jochen Seufert

Diabetes 2004 Feb; 53 (suppl 1): S82-S85. https://doi.org/10.2337/diabetes.53.2007.S82

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Novel Players in Pancreatic Islet SignalingFrom Membrane Receptors to Nuclear Channels
Bernat Soria, Ivan Quesada, Ana B. Ropero, José A. Pertusa, Franz Martín and Angel Nadal

Diabetes 2004 Feb; 53 (suppl 1): S86-S91. https://doi.org/10.2337/diabetes.53.2007.S86

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Nutrients Induce Different Ca²⁺ Signals in Cytosol and Nucleus in Pancreatic β-Cells
Ivan Quesada, Franz Martin, Enrique Roche and Bernat Soria

Diabetes 2004 Feb; 53 (suppl 1): S92-S95. https://doi.org/10.2337/diabetes.53.2007.S92

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Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes

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Roles of Mitochondria in Health and Disease
Michael R. Duchen

Diabetes 2004 Feb; 53 (suppl 1): S96-S102. https://doi.org/10.2337/diabetes.53.2007.S96

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Mitochondrial DiabetesMolecular Mechanisms and Clinical Presentation
J. Antonie Maassen, Leen. M. ‘t Hart, Einar van Essen, Rob J. Heine, Giel Nijpels, Roshan S. Jahangir Tafrechi, Anton K. Raap, George M.C. Janssen and Herman H.P.J. Lemkes

Diabetes 2004 Feb; 53 (suppl 1): S103-S109. https://doi.org/10.2337/diabetes.53.2007.S103

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Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in Diabetes
Katherine Green, Martin D. Brand and Michael P. Murphy

Diabetes 2004 Feb; 53 (suppl 1): S110-S118. https://doi.org/10.2337/diabetes.53.2007.S110

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β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes
R. Paul Robertson, Jamie Harmon, Phuong Oanh T. Tran and Vincent Poitout

Diabetes 2004 Feb; 53 (suppl 1): S119-S124. https://doi.org/10.2337/diabetes.53.2007.S119

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ALS/Lt: A New Type 2 Diabetes Mouse Model Associated With Low Free Radical Scavenging Potential
Clayton E. Mathews, Rebecca Bagley and Edward H. Leiter

Diabetes 2004 Feb; 53 (suppl 1): S125-S129. https://doi.org/10.2337/diabetes.53.2007.S125

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The Biology of Mitochondrial Uncoupling Proteins
Sophie Rousset, Marie-Clotilde Alves-Guerra, Julien Mozo, Bruno Miroux, Anne-Marie Cassard-Doulcier, Frédéric Bouillaud and Daniel Ricquier

Diabetes 2004 Feb; 53 (suppl 1): S130-S135. https://doi.org/10.2337/diabetes.53.2007.S130

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Uncoupling Protein 2 and Islet Function
Catherine B. Chan, Monique C. Saleh, Vasilij Koshkin and Michael B. Wheeler

Diabetes 2004 Feb; 53 (suppl 1): S136-S142. https://doi.org/10.2337/diabetes.53.2007.S136

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Section IV: Lipid Modulators of Islet Function

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Update on Adipocyte HormonesRegulation of Energy Balance and Carbohydrate/Lipid Metabolism
Peter J. Havel

Diabetes 2004 Feb; 53 (suppl 1): S143-S151. https://doi.org/10.2337/diabetes.53.2007.S143

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Leptin Effects on Pancreatic β-Cell Gene Expression and Function
Jochen Seufert

Diabetes 2004 Feb; 53 (suppl 1): S152-S158. https://doi.org/10.2337/diabetes.53.2007.S152

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Chronic Effects of Fatty Acids on Pancreatic β-Cell FunctionNew Insights From Functional Genomics
Trevor J. Biden, Darren Robinson, Damien Cordery, William E. Hughes and Anna K. Busch

Diabetes 2004 Feb; 53 (suppl 1): S159-S165. https://doi.org/10.2337/diabetes.53.2007.S159

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Acute ω-3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance
Mark J. Holness, Nicholas D. Smith, Gemma K. Greenwood and Mary C. Sugden

Diabetes 2004 Feb; 53 (suppl 1): S166-S171. https://doi.org/10.2337/diabetes.53.2007.S166

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The Role of Cytosolic Phospholipase A₂ in Insulin Secretion
Peter M. Jones, Christopher J. Burns, Véronique D. Belin, Helen M. Roderigo-Milne and Shanta J. Persaud

Diabetes 2004 Feb; 53 (suppl 1): S172-S178. https://doi.org/10.2337/diabetes.53.2007.S172

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Islet Complex LipidsInvolvement in the Actions of Group VIA Calcium-Independent Phospholipase A₂ in β-Cells
Sasanka Ramanadham, Haowei Song, Shunzhong Bao, Fong-Fu Hsu, Sheng Zhang, Zhongmin Ma, Chun Jin and John Turk

Diabetes 2004 Feb; 53 (suppl 1): S179-S185. https://doi.org/10.2337/diabetes.53.2007.S179

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β-Cell Calcium-Independent Group VIA Phospholipase A₂ (iPLA₂β)Tracking iPLA₂β Movements in Response to Stimulation With Insulin Secretagogues in INS-1 Cells
Shunzhong Bao, Chun Jin, Sheng Zhang, John Turk, Zhongmin Ma and Sasanka Ramanadham

Diabetes 2004 Feb; 53 (suppl 1): S186-S189. https://doi.org/10.2337/diabetes.53.2007.S186

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Glucose-Induced Regulation of COX-2 Expression in Human Islets of Langerhans
Shanta J. Persaud, Chris J. Burns, Véronique D. Belin and Peter M. Jones

Diabetes 2004 Feb; 53 (suppl 1): S190-S192. https://doi.org/10.2337/diabetes.53.2007.S190

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Table of Contents

Novel Factors in the Regulation of Beta-Cell Function

Editorial

Section I: Genetic Factors in Type 2 Diabetes -- In Search of New Links

Section II: Nuclear Receptors and Islet Function

Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes

Section IV: Lipid Modulators of Islet Function

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