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Islet Studies

Mechanisms of Glucose-Induced Secretion of Pancreatic-Derived Factor (PANDER or FAM3B) in Pancreatic β-Cells

  1. Jichun Yang,
  2. Claudia E. Robert,
  3. Brant R. Burkhardt,
  4. Robert A. Young,
  5. Jianmei Wu,
  6. Zhiyong Gao and
  7. Bryan A. Wolf
  1. From the Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  1. Address correspondence and reprint requests to Dr. Bryan A. Wolf, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, 5135 Main Bldg, 34th St. and Civic Center Blvd., Philadelphia, PA 19104-4399. E-mail: wolfb{at}mail.med.upenn.edu
Diabetes 2005 Nov; 54(11): 3217-3228. https://doi.org/10.2337/diabetes.54.11.3217
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Article Information

vol. 54 no. 11 3217-3228
DOI 
https://doi.org/10.2337/diabetes.54.11.3217
PubMed 
16249448

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received May 6, 2005
  • Accepted August 3, 2005
  • Published in print October 25, 2005.

Copyright & Usage 
DIABETES

Author Information

  1. Jichun Yang,
  2. Claudia E. Robert,
  3. Brant R. Burkhardt,
  4. Robert A. Young,
  5. Jianmei Wu,
  6. Zhiyong Gao and
  7. Bryan A. Wolf
  1. From the Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  1. Address correspondence and reprint requests to Dr. Bryan A. Wolf, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, 5135 Main Bldg, 34th St. and Civic Center Blvd., Philadelphia, PA 19104-4399. E-mail: wolfb{at}mail.med.upenn.edu
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Mechanisms of Glucose-Induced Secretion of Pancreatic-Derived Factor (PANDER or FAM3B) in Pancreatic β-Cells
Jichun Yang, Claudia E. Robert, Brant R. Burkhardt, Robert A. Young, Jianmei Wu, Zhiyong Gao, Bryan A. Wolf
Diabetes Nov 2005, 54 (11) 3217-3228; DOI: 10.2337/diabetes.54.11.3217

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Mechanisms of Glucose-Induced Secretion of Pancreatic-Derived Factor (PANDER or FAM3B) in Pancreatic β-Cells
Jichun Yang, Claudia E. Robert, Brant R. Burkhardt, Robert A. Young, Jianmei Wu, Zhiyong Gao, Bryan A. Wolf
Diabetes Nov 2005, 54 (11) 3217-3228; DOI: 10.2337/diabetes.54.11.3217
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Keywords

CCH, carbachol
FBS, fetal bovine serum
IFN, interferon
IL, interleukin
KRBB, Krebs-Ringer bicarbonate buffer
PANDER, pancreatic-derived factor (or FAM3B)
TBST, Tris-buffered saline with Tween
TNF, tumor necrosis factor

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  • Retinol-Binding Protein 4 Activates STRA6, Provoking Pancreatic β-Cell Dysfunction in Type 2 Diabetes
  • Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction
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