Genetics

Protein Tyrosine Phosphatase-1B Gene PTPN1

Selection of Tagging Single Nucleotide Polymorphisms and Association With Body Fat, Insulin Sensitivity, and the Metabolic Syndrome in a Normal Female Population

  1. Nicola J. Spencer-Jones1,
  2. Xiaoling Wang2,
  3. Harold Snieder2,3,
  4. Tim D. Spector3,
  5. Nicholas D. Carter1 and
  6. Sandra D. O’Dell1
  1. 1Department of Clinical Developmental Sciences, St. George’s, University of London, London, U.K
  2. 2Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia
  3. 3Twin Research and Genetic Epidemiology Unit, St. Thomas’ Hospital, London, U.K
  1. Address correspondence and reprint requests to Dr. Sandra D. O’Dell, Nutrition Food and Health Centre, King’s College London, Franklin-Wilkins Building, 150 Stamford St., London SE19H, U.K. E-mail: sandra.o'dell{at}kcl.ac.uk
Diabetes 2005 Nov; 54(11): 3296-3304. https://doi.org/10.2337/diabetes.54.11.3296

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November 2005, 54(11)
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Protein Tyrosine Phosphatase-1B Gene PTPN1
Nicola J. Spencer-Jones, Xiaoling Wang, Harold Snieder, Tim D. Spector, Nicholas D. Carter, Sandra D. O’Dell
Diabetes Nov 2005, 54 (11) 3296-3304; DOI: 10.2337/diabetes.54.11.3296
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Keywords

DBP, diastolic blood pressure
GEE, generalized estimating equation
MAF, minor allele frequency
PTP-1B, protein tyrosine phosphatase-1B
SBP, systolic blood pressure
SiM, Avignon’s insulin sensitivity index based on both fasting and 2-h insulin and glucose values
SNP, single nucleotide polymorphism
TDT, transmission-disequilibrium test
tSNP, tagging SNP

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