Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes
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Figures
- FIG. 1.
Hypoglycemia-associated autonomic failure in type 1 diabetes. Modified from ref. 1. © 2004 by the MA Medical Society.
Tables
- TABLE 1
Mechanisms of the fundamental components of hypoglycemia-associated autonomic failure in diabetes
Loss of the glucagon response: the intraislet insulin hypothesis Reduced awareness: the sympathetic neural hypothesis Reduced sympathoadrenal responses The central nervous system premise The systemic mediator hypothesis The brain fuel transport hypothesis The brain metabolism hypothesis The brain glycogen supercompensation hypothesis
In this Issue
December 2005, 54(12)
Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes
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- Article
- Abstract
- THE CLINICAL PROBLEM
- THE PATHOPHYSIOLOGY OF GLUCOSE COUNTERREGULATION IN DIABETES
- HAAF IN DIABETES
- THE MECHANISM OF THE LOSS OF THE GLUCAGON RESPONSE TO HYPOGLYCEMIA IN INSULIN-DEFICIENT DIABETES: THE INTRAISLET INSULIN HYPOTHESIS
- THE MECHANISM OF HYPOGLYCEMIA UNAWARENESS IN DIABETES: THE SYMPATHETIC NEURAL HYPOTHESIS
- THE MECHANISM OF THE SHIFT OF THE GLYCEMIC THRESHOLDS FOR SYMPATHOADRENAL ACTIVATION TO LOWER PLASMA GLUCOSE CONCENTRATIONS BY RECENT ANTECEDENT HYPOGLYCEMIA
- The CNS premise.
- The systemic mediator hypothesis.
- The brain fuel transport hypothesis.
- The brain metabolism hypothesis.
- The brain glycogen supercompensation hypothesis.
- DIVERSE CAUSES OF HAAF IN DIABETES
- COMMENT
- Acknowledgments
- Footnotes
- REFERENCES
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