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Table of Contents

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October 01 2006; volume 55 issue 10

Signal Transduction

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    Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice
    Sarah L. Gray, Edoardo Dalla Nora, Johannes Grosse, Monia Manieri, Tobias Stoeger, Gema Medina-Gomez, Keith Burling, Sigrid Wattler, Andreas Russ, Giles S.H. Yeo, V. Krishna Chatterjee, Stephen O’Rahilly, Peter J. Voshol, Saverio Cinti and Antonio Vidal-Puig
    Diabetes 2006 Oct; 55 (10): 2669-2677. https://doi.org/10.2337/db06-0389
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    Bradykinin Augments Insulin-Stimulated Glucose Transport in Rat Adipocytes via Endothelial Nitric Oxide Synthase–Mediated Inhibition of Jun NH2-Terminal Kinase
    Kristin M. Beard, Huogen Lu, Karen Ho and I. George Fantus
    Diabetes 2006 Oct; 55 (10): 2678-2687. https://doi.org/10.2337/db05-1538
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    Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
    Andrew L. Carey, Gregory R. Steinberg, S. Lance Macaulay, Walter G. Thomas, Anna G. Holmes, Georg Ramm, Oja Prelovsek, Cordula Hohnen-Behrens, Matthew J. Watt, David E. James, Bruce E. Kemp, Bente K. Pedersen and Mark A. Febbraio
    Diabetes 2006 Oct; 55 (10): 2688-2697. https://doi.org/10.2337/db05-1404
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    Mechanisms of the Depot Specificity of Peroxisome Proliferator–Activated Receptor γ Action on Adipose Tissue Metabolism
    Mathieu Laplante, William T. Festuccia, Geneviève Soucy, Yves Gélinas, Josée Lalonde, Joel P. Berger and Yves Deshaies
    Diabetes 2006 Oct; 55 (10): 2771-2778. https://doi.org/10.2337/db06-0551
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    Palmitate-Mediated Downregulation of Peroxisome Proliferator–Activated Receptor-γ Coactivator 1α in Skeletal Muscle Cells Involves MEK1/2 and Nuclear Factor-κB Activation
    Teresa Coll, Mireia Jové, Ricardo Rodríguez-Calvo, Elena Eyre, Xavier Palomer, Rosa M. Sánchez, Manuel Merlos, Juan Carlos Laguna and Manuel Vázquez-Carrera
    Diabetes 2006 Oct; 55 (10): 2779-2787. https://doi.org/10.2337/db05-1494
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    Central and Opposing Effects of IGF-I and IGF-Binding Protein-3 on Systemic Insulin Action
    Radhika H. Muzumdar, Xiaohui Ma, Sigal Fishman, Xiaoman Yang, Gil Atzmon, Patricia Vuguin, Francine H. Einstein, David Hwang, Pinchas Cohen and Nir Barzilai
    Diabetes 2006 Oct; 55 (10): 2788-2796. https://doi.org/10.2337/db06-0318
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    Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase–Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat–Fed Rats
    Ji-Ming Ye, Nick Dzamko, Andrew J. Hoy, Miguel A. Iglesias, Bruce Kemp and Edward Kraegen
    Diabetes 2006 Oct; 55 (10): 2797-2804. https://doi.org/10.2337/db05-1315
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Obesity Studies

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    Impaired Adipose Tissue Development in Mice With Inactivation of Placental Growth Factor Function
    H. Roger Lijnen, Valerie Christiaens, Ilse Scroyen, Gabor Voros, Marc Tjwa, Peter Carmeliet and Désiré Collen
    Diabetes 2006 Oct; 55 (10): 2698-2704. https://doi.org/10.2337/db06-0526
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    Retinol-Binding Protein 4 in Human Obesity
    Jürgen Janke, Stefan Engeli, Michael Boschmann, Frauke Adams, Jana Böhnke, Friedrich C. Luft, Arya M. Sharma and Jens Jordan
    Diabetes 2006 Oct; 55 (10): 2805-2810. https://doi.org/10.2337/db06-0616
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    Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator–Activated Receptor γ Activation
    Aiwei Yao-Borengasser, Neda Rasouli, Vijayalakshmi Varma, Leslie M. Miles, Bounleut Phanavanh, Tasha N. Starks, Jack Phan, Horace J. Spencer, Robert E. McGehee, Karen Reue and Philip A. Kern
    Diabetes 2006 Oct; 55 (10): 2811-2818. https://doi.org/10.2337/db05-1688
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Islet Studies

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    STAT5 Activity in Pancreatic β-Cells Influences the Severity of Diabetes in Animal Models of Type 1 and 2 Diabetes
    Malene Jackerott, Annette Møldrup, Peter Thams, Elisabeth D. Galsgaard, Jakob Knudsen, Ying C. Lee and Jens Høiriis Nielsen
    Diabetes 2006 Oct; 55 (10): 2705-2712. https://doi.org/10.2337/db06-0244
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    Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets
    Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier and Marc Y. Donath
    Diabetes 2006 Oct; 55 (10): 2713-2722. https://doi.org/10.2337/db05-1430
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    Impact of Defined Matrix Interactions on Insulin Production by Cultured Human β-CellsEffect on Insulin Content, Secretion, and Gene Transcription
    Thomas Kaido, Mayra Yebra, Vincenzo Cirulli, Christopher Rhodes, Giuseppe Diaferia and Anthony M. Montgomery
    Diabetes 2006 Oct; 55 (10): 2723-2729. https://doi.org/10.2337/db06-0120
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    Foxa1-Deficient Mice Exhibit Impaired Insulin Secretion due to Uncoupled Oxidative Phosphorylation
    Marko Z. Vatamaniuk, Rana K. Gupta, Kristen A. Lantz, Nicolai M. Doliba, Franz M. Matschinsky and Klaus H. Kaestner
    Diabetes 2006 Oct; 55 (10): 2730-2736. https://doi.org/10.2337/db05-0470
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    Suppressed Insulin Signaling and Increased Apoptosis in Cd38-Null Islets
    James D. Johnson, Eric L. Ford, Ernesto Bernal-Mizrachi, Kim L. Kusser, Dan S. Luciani, Zhiqiang Han, Hung Tran, Troy D. Randall, Frances E. Lund and Kenneth S. Polonsky
    Diabetes 2006 Oct; 55 (10): 2737-2746. https://doi.org/10.2337/db05-1455
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    Imaging Docking and Fusion of Insulin Granules Induced by Antidiabetes AgentsSulfonylurea and Glinide Drugs Preferentially Mediate the Fusion of Newcomer, but Not Previously Docked, Insulin Granules
    Shinya Nagamatsu, Mica Ohara-Imaizumi, Yoko Nakamichi, Toshiteru Kikuta and Chiyono Nishiwaki
    Diabetes 2006 Oct; 55 (10): 2819-2825. https://doi.org/10.2337/db06-0105
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    C16:0 Sulfatide Inhibits Insulin Secretion in Rat β-Cells by Reducing the Sensitivity of KATP Channels to ATP Inhibition
    Karsten Buschard, Maria Blomqvist, Jan-Eric Månsson, Pam Fredman, Kirstine Juhl and Jesper Gromada
    Diabetes 2006 Oct; 55 (10): 2826-2834. https://doi.org/10.2337/db05-1355
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    Identification of Insulin Signaling Elements in Human β-CellsAutocrine Regulation of Insulin Gene Expression
    Dany Muller, Guo Cai Huang, Stephanie Amiel, Peter M. Jones and Shanta J. Persaud
    Diabetes 2006 Oct; 55 (10): 2835-2842. https://doi.org/10.2337/db06-0532
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Complications

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    Altered Gene Expression Related to Glomerulogenesis and Podocyte Structure in Early Diabetic Nephropathy of db/db Mice and Its Restoration by Pioglitazone
    Hisashi Makino, Yoshihiro Miyamoto, Kazutomo Sawai, Kiyoshi Mori, Masashi Mukoyama, Kazuwa Nakao, Yasunao Yoshimasa and Shin-ichi Suga
    Diabetes 2006 Oct; 55 (10): 2747-2756. https://doi.org/10.2337/db05-1683
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    A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy
    Wei Sun, Peter J. Oates, James B. Coutcher, Chiara Gerhardinger and Mara Lorenzi
    Diabetes 2006 Oct; 55 (10): 2757-2762. https://doi.org/10.2337/db06-0138
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    Insulin Restores Metabolic Function in Cultured Cortical Neurons Subjected to Oxidative Stress
    Ana I. Duarte, Teresa Proença, Catarina R. Oliveira, Maria S. Santos and A. Cristina Rego
    Diabetes 2006 Oct; 55 (10): 2863-2870. https://doi.org/10.2337/db06-0030
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Genetics

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    Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes
    Teresa Soccio, Yuan-Yuan Zhang, Simonetta Bacci, Wojciech Mlynarski, Grzegorz Placha, Greer Raggio, Rosa Di Paola, Antonella Marucci, Michael T. Johnstone, Ernest V. Gervino, Nada A. Abumrad, Samuel Klein, Vincenzo Trischitta and Alessandro Doria
    Diabetes 2006 Oct; 55 (10): 2763-2770. https://doi.org/10.2337/db06-0613
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    Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians
    Michael Benzinou, Andrew Walley, Stephan Lobbens, Marie-Aline Charles, Béatrice Jouret, Frédéric Fumeron, Beverley Balkau, David Meyre and Philippe Froguel
    Diabetes 2006 Oct; 55 (10): 2876-2882. https://doi.org/10.2337/db06-0337
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    A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 Diabetes
    Suna Onengut-Gumuscu, Jane H. Buckner and Patrick Concannon
    Diabetes 2006 Oct; 55 (10): 2883-2889. https://doi.org/10.2337/db06-0225
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Pathophysiology

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    Immunoneutralization of Endogenous Glucagon Reduces Hepatic Glucose Output and Improves Long-Term Glycemic Control in Diabetic ob/ob Mice
    Heidi Sørensen, Christian L. Brand, Susanne Neschen, Jens Juul Holst, Keld Fosgerau, Erica Nishimura and Gerald I. Shulman
    Diabetes 2006 Oct; 55 (10): 2843-2848. https://doi.org/10.2337/db06-0222
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    Whole-Body Proteolysis Rate Is Elevated in HIV-Associated Insulin Resistance
    Dominic N. Reeds, W. Todd Cade, Bruce W. Patterson, William G. Powderly, Samuel Klein and Kevin E. Yarasheski
    Diabetes 2006 Oct; 55 (10): 2849-2855. https://doi.org/10.2337/db06-0255
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    Vitamin E and Risk of Type 2 Diabetes in the Women’s Health Study Randomized Controlled Trial
    Simin Liu, I-Min Lee, Yiqing Song, Martin Van Denburgh, Nancy R. Cook, JoAnn E. Manson and Julie E. Buring
    Diabetes 2006 Oct; 55 (10): 2856-2862. https://doi.org/10.2337/db06-0456
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Pharmacology and Therapeutics

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    Serum Visfatin Increases With Progressive β-Cell Deterioration
    Abel López-Bermejo, Berta Chico-Julià, Mercè Fernàndez-Balsells, Mònica Recasens, Eduardo Esteve, Roser Casamitjana, Wifredo Ricart and José-Manuel Fernández-Real
    Diabetes 2006 Oct; 55 (10): 2871-2875. https://doi.org/10.2337/db06-0259
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Brief Genetics Reports

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    Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals
    Richa Saxena, Lauren Gianniny, Noël P. Burtt, Valeriya Lyssenko, Candace Giuducci, Marketa Sjögren, Jose C. Florez, Peter Almgren, Bo Isomaa, Marju Orho-Melander, Ulf Lindblad, Mark J. Daly, Tiinamaija Tuomi, Joel N. Hirschhorn, Kristin G. Ardlie, Leif C. Groop and David Altshuler
    Diabetes 2006 Oct; 55 (10): 2890-2895. https://doi.org/10.2337/db06-0381
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    Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population
    Swneke D. Bailey, J C. Loredo-Osti, Pierre Lepage, Janet Faith, Joelle Fontaine, Katia M. Desbiens, Thomas J. Hudson, Claude Bouchard, Daniel Gaudet, Louis Pérusse, Marie-Claude Vohl and James C. Engert
    Diabetes 2006 Oct; 55 (10): 2896-2902. https://doi.org/10.2337/db06-0189
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    Transcription Factor TCF7L2 Genetic Study in the French PopulationExpression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes
    Stéphane Cauchi, David Meyre, Christian Dina, Hélène Choquet, Chantal Samson, Sophie Gallina, Beverley Balkau, Guillaume Charpentier, François Pattou, Volodymyr Stetsyuk, Raphaël Scharfmann, Bart Staels, Gema Frühbeck and Philippe Froguel
    Diabetes 2006 Oct; 55 (10): 2903-2908. https://doi.org/10.2337/db06-0474
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    Role of a Proline Insertion in the Insulin Promoter Factor 1 (IPF1) Gene in African Americans With Type 2 Diabetes
    Steven C. Elbein, Xiaoqin Wang, Mohammad A. Karim, Barry I. Freedman, Donald W. Bowden, Alan R. Shuldiner, Frederick L. Brancati and Wen Hong Linda Kao
    Diabetes 2006 Oct; 55 (10): 2909-2914. https://doi.org/10.2337/db06-0434
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    IL6 Gene Promoter Polymorphisms and Type 2 DiabetesJoint Analysis of Individual Participants’ Data From 21 Studies
    Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, Johanna K. Wolford, Birgit Langer, Barbara Thorand, Norman Klopp, Yasmin H. Hamid, Oluf Pedersen, Torben Hansen, Valeriya Lyssenko, Leif Groop, Christa Meisinger, Angela Döring, Hannelore Löwel, Wolfgang Lieb, Christian Hengstenberg, Wolfgang Rathmann, Stephan Martin, Jeffrey W. Stephens, Helen Ireland, Hugh Mather, George J. Miller, Heather M. Stringham, Michael Boehnke, Jaakko Tuomilehto, Heiner Boeing, Matthias Möhlig, Joachim Spranger, Andreas Pfeiffer, Ingrid Wernstedt, Anders Niklason, Abel López-Bermejo, José-Manuel Fernández-Real, Robert L. Hanson, Luis Gallart, Joan Vendrell, Anastasia Tsiavou, Erifili Hatziagelaki, Steve E. Humphries, H.-Erich Wichmann, Christian Herder and Thomas Illig
    Diabetes 2006 Oct; 55 (10): 2915-2921. https://doi.org/10.2337/db06-0600
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    The α-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes
    Mojgan Yazdanpanah, Fakhredin A. Sayed-Tabatabaei, Albert Hofman, Yurii S. Aulchenko, Ben A. Oostra, Bruno H.C. Stricker, Huibert A.P. Pols, Steven W.J. Lamberts, Jacqueline C.M. Witteman, Joop A.M.J.L. Janssen and Cornelia M. van Duijn
    Diabetes 2006 Oct; 55 (10): 2922-2927. https://doi.org/10.2337/db06-0302
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October 2006, 55(10)
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