Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

Marcela Brissova; Alena Shostak; Masakazu Shiota; Peter O. Wiebe; Greg Poffenberger; Jeannelle Kantz; Zhongyi Chen; Chad Carr; W. Gray Jerome; Jin Chen; H. Scott Baldwin; Wendell Nicholson; David M. Bader; Thomas Jetton; Maureen Gannon; Alvin C. Powers

doi:10.2337/db06-0690

Islet Studies

Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

Marcela Brissova1,
Alena Shostak1,
Masakazu Shiota2,
Peter O. Wiebe2,
Greg Poffenberger1,
Jeannelle Kantz2,
Zhongyi Chen1,
Chad Carr1,
W. Gray Jerome3 4,
Jin Chen4 5,
H. Scott Baldwin6,
Wendell Nicholson1,
David M. Bader7,
Thomas Jetton8,
Maureen Gannon1 2 and
Alvin C. Powers1 2 9

¹Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
²Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee
³Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee
⁴Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee
⁵Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee
⁶Division of Pediatric Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
⁷Stahlman Laboratory, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
⁸Division of Endocrinology and Metabolism, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont
⁹Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee

Address correspondence and reprint requests to Alvin C. Powers, Division of Diabetes, Endocrinology, and Metabolism, 715 PRB, Vanderbilt University, Nashville, TN 37232. E-mail: al.powers{at}vanderbilt.edu

Diabetes 2006 Nov; 55(11): 2974-2985. https://doi.org/10.2337/db06-0690

Article Information

vol. 55 no. 11 2974-2985

DOI

https://doi.org/10.2337/db06-0690

PubMed

17065333

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

July 19, 2006
May 18, 2006
Published in print October 25, 2006.

DIABETES

Author Information

Marcela Brissova1,
Alena Shostak1,
Masakazu Shiota2,
Peter O. Wiebe2,
Greg Poffenberger1,
Jeannelle Kantz2,
Zhongyi Chen1,
Chad Carr1,
W. Gray Jerome3 4,
Jin Chen4 5,
H. Scott Baldwin6,
Wendell Nicholson1,
David M. Bader7,
Thomas Jetton8,
Maureen Gannon1 2 and
Alvin C. Powers1 2 9

¹Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
²Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee
³Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee
⁴Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee
⁵Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee
⁶Division of Pediatric Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
⁷Stahlman Laboratory, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
⁸Division of Endocrinology and Metabolism, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont
⁹Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee

Address correspondence and reprint requests to Alvin C. Powers, Division of Diabetes, Endocrinology, and Metabolism, 715 PRB, Vanderbilt University, Nashville, TN 37232. E-mail: al.powers{at}vanderbilt.edu

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