Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans

Michiel E. Stegenga; Saskia N. van der Crabben; Marcel Levi; Alex F. de Vos; Michael W. Tanck; Hans P. Sauerwein; Tom van der Poll

doi:10.2337/db05-1543

Pathophysiology

Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans

Michiel E. Stegenga1 2,
Saskia N. van der Crabben3,
Marcel Levi4,
Alex F. de Vos1 2,
Michael W. Tanck5,
Hans P. Sauerwein3 and
Tom van der Poll1 2

¹Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
²Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
³Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
⁴Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
⁵Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Address correspondence and reprint requests to Michiel E. Stegenga, MD, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, G2-130, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. E-mail: m.e.stegenga{at}amc.uva.nl

Diabetes 2006 Jun; 55(6): 1807-1812. https://doi.org/10.2337/db05-1543

Article Information

vol. 55 no. 6 1807-1812

DOI

https://doi.org/10.2337/db05-1543

PubMed

16731846

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

February 22, 2006
November 29, 2005
Published in print May 26, 2006.

DIABETES

Author Information

Michiel E. Stegenga1 2,
Saskia N. van der Crabben3,
Marcel Levi4,
Alex F. de Vos1 2,
Michael W. Tanck5,
Hans P. Sauerwein3 and
Tom van der Poll1 2

¹Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
²Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
³Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
⁴Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
⁵Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Address correspondence and reprint requests to Michiel E. Stegenga, MD, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, G2-130, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. E-mail: m.e.stegenga{at}amc.uva.nl

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