Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans
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Figures
- FIG. 1.
Plasma concentrations of glucose and insulin. Data are presented as means ± SD from six subjects studied on four separate occasions: during an LinsuEgluc clamp (□), an LinsuHgluc clamp (○), an HinsuEgluc clamp (▪), and an HinsuHgluc clamp (•). Glucose (left axis) was measured every 5 min; insulin (right axis) was measured at 0, 3, and 6 h.
- FIG. 2.
Hyperglycemia activates coagulation irrespective of insulin levels. Mean ± SD plasma concentrations of TATc (A) and soluble tissue factor (B) measured in six subjects studied on four separate occasions: during an LinsuEgluc clamp (□), an LinsuHgluc clamp (○), an HinsuEgluc clamp (▪), and an HinsuHgluc clamp (•). *P < 0.001 vs. both euglycemic clamps.
- FIG. 3.
Hyperinsulinemia inhibits fibrinolysis irrespective of glucose levels. Mean ± SD plasma concentrations of tPA antigen (A), plasminogen activator activity (PA activity) (B), PAI-1 antigen (C), and PAI-1 activity (D) measured in six subjects studied on four separate occasions: during an LinsuEgluc clamp (□), an LinsuHgluc clamp (○), an HinsuEgluc clamp (▪), and an HinsuHgluc clamp (•). *P < 0.01 vs. both lower insulinemic clamps; †P < 0.05 vs. LinsuEgluc clamp.
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