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Pathophysiology

Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans

  1. Michiel E. Stegenga12,
  2. Saskia N. van der Crabben3,
  3. Marcel Levi4,
  4. Alex F. de Vos12,
  5. Michael W. Tanck5,
  6. Hans P. Sauerwein3 and
  7. Tom van der Poll12
  1. 1Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
  2. 2Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
  3. 3Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
  4. 4Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
  5. 5Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
  1. Address correspondence and reprint requests to Michiel E. Stegenga, MD, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, G2-130, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. E-mail: m.e.stegenga{at}amc.uva.nl
Diabetes 2006 Jun; 55(6): 1807-1812. https://doi.org/10.2337/db05-1543
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    FIG. 1.

    Plasma concentrations of glucose and insulin. Data are presented as means ± SD from six subjects studied on four separate occasions: during an LinsuEgluc clamp (□), an LinsuHgluc clamp (○), an HinsuEgluc clamp (▪), and an HinsuHgluc clamp (•). Glucose (left axis) was measured every 5 min; insulin (right axis) was measured at 0, 3, and 6 h.

  • FIG. 2.
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    FIG. 2.

    Hyperglycemia activates coagulation irrespective of insulin levels. Mean ± SD plasma concentrations of TATc (A) and soluble tissue factor (B) measured in six subjects studied on four separate occasions: during an LinsuEgluc clamp (□), an LinsuHgluc clamp (○), an HinsuEgluc clamp (▪), and an HinsuHgluc clamp (•). *P < 0.001 vs. both euglycemic clamps.

  • FIG. 3.
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    FIG. 3.

    Hyperinsulinemia inhibits fibrinolysis irrespective of glucose levels. Mean ± SD plasma concentrations of tPA antigen (A), plasminogen activator activity (PA activity) (B), PAI-1 antigen (C), and PAI-1 activity (D) measured in six subjects studied on four separate occasions: during an LinsuEgluc clamp (□), an LinsuHgluc clamp (○), an HinsuEgluc clamp (▪), and an HinsuHgluc clamp (•). *P < 0.01 vs. both lower insulinemic clamps; †P < 0.05 vs. LinsuEgluc clamp.

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June 2006, 55(6)
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Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans
Michiel E. Stegenga, Saskia N. van der Crabben, Marcel Levi, Alex F. de Vos, Michael W. Tanck, Hans P. Sauerwein, Tom van der Poll
Diabetes Jun 2006, 55 (6) 1807-1812; DOI: 10.2337/db05-1543

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Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans
Michiel E. Stegenga, Saskia N. van der Crabben, Marcel Levi, Alex F. de Vos, Michael W. Tanck, Hans P. Sauerwein, Tom van der Poll
Diabetes Jun 2006, 55 (6) 1807-1812; DOI: 10.2337/db05-1543
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