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Table of Contents

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December 01 2007; volume 56 issue 12

Editorial

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    Lost in TranslationFacing Up to Translational Research
    James Levine
    Diabetes 2007 Dec; 56 (12): 2841. https://doi.org/10.2337/db07-1371
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Commentaries

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    Genetic Factors in Type 2 DiabetesAll in the (Lipin) Family
    Karen Reue and Jimmy Donkor
    Diabetes 2007 Dec; 56 (12): 2842-2843. https://doi.org/10.2337/db07-1288
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    Genome-Wide AssociationWhich Do You Want First: the Good News, the Bad News, or the Good News?
    Kent D. Taylor, Jill M. Norris and Jerome I. Rotter
    Diabetes 2007 Dec; 56 (12): 2844-2848. https://doi.org/10.2337/db07-1324
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Metabolism

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    Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects
    Rutger W. van der Meer, Sebastiaan Hammer, Johannes W.A. Smit, Marijke Frölich, Jeroen J. Bax, Michaela Diamant, Luuk J. Rijzewijk, Albert de Roos, Johannes A. Romijn and Hildo J. Lamb
    Diabetes 2007 Dec; 56 (12): 2849-2853. https://doi.org/10.2337/db07-0768
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    Calmodulin-Binding Domain of AS160 Regulates Contraction- but Not Insulin-Stimulated Glucose Uptake in Skeletal Muscle
    Henning F. Kramer, Eric B. Taylor, Carol A. Witczak, Nobuharu Fujii, Michael F. Hirshman and Laurie J. Goodyear
    Diabetes 2007 Dec; 56 (12): 2854-2862. https://doi.org/10.2337/db07-0681
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    Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity
    Debby P.Y. Koonen, René L. Jacobs, Maria Febbraio, Martin E. Young, Carrie-Lynn M. Soltys, Huy Ong, Dennis E. Vance and Jason R.B. Dyck
    Diabetes 2007 Dec; 56 (12): 2863-2871. https://doi.org/10.2337/db07-0907
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    Central Insulin Regulates Heart Rate and Arterial Blood FlowAn Endothelial Nitric Oxide Synthase–Dependent Mechanism Altered During Diabetes
    Cendrine Cabou, Patrice D. Cani, Gérard Campistron, Claude Knauf, Caroline Mathieu, Claudio Sartori, Jacques Amar, Urs Scherrer and Rémy Burcelin
    Diabetes 2007 Dec; 56 (12): 2872-2877. https://doi.org/10.2337/db07-0115
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    Splanchnic Spillover of Extracellular Lipase–Generated Fatty Acids in Overweight and Obese Humans
    Robert H. Nelson, Rita Basu, C. Michael Johnson, Robert A. Rizza and John M. Miles
    Diabetes 2007 Dec; 56 (12): 2878-2884. https://doi.org/10.2337/db07-0812
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    Local Nitric Oxide Synthase Inhibition Reduces Skeletal Muscle Glucose Uptake but Not Capillary Blood Flow During In Situ Muscle Contraction in Rats
    Renee M. Ross, Glenn D. Wadley, Michael G. Clark, Stephen Rattigan and Glenn K. McConell
    Diabetes 2007 Dec; 56 (12): 2885-2892. https://doi.org/10.2337/db07-0745
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Signal Transduction

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    Mechanisms of Low-Glucose Sensitivity in Carotid Body Glomus Cells
    María García-Fernández, Patricia Ortega-Sáenz, Antonio Castellano and José López-Barneo
    Diabetes 2007 Dec; 56 (12): 2893-2900. https://doi.org/10.2337/db07-0122
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    Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase–Mediated Gluconeogenesis
    Ning-Chun Liu, Wen-Jye Lin, Eungseok Kim, Loretta L. Collins, Hung-Yun Lin, I-Chen Yu, Janet D. Sparks, Lu-Min Chen, Yi-Fen Lee and Chawnshang Chang
    Diabetes 2007 Dec; 56 (12): 2901-2909. https://doi.org/10.2337/db07-0359
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Obesity Studies

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    Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
    Katherine J. Strissel, Zlatina Stancheva, Hideaki Miyoshi, James W. Perfield, Jason DeFuria, Zoe Jick, Andrew S. Greenberg and Martin S. Obin
    Diabetes 2007 Dec; 56 (12): 2910-2918. https://doi.org/10.2337/db07-0767
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Immunology and Transplantation

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    Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice
    Suzanne D. Burke, Hongmei Dong, Aleah D. Hazan and B. Anne Croy
    Diabetes 2007 Dec; 56 (12): 2919-2926. https://doi.org/10.2337/db07-0773
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Islet Studies

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    Free Fatty Acid–Induced Reduction in Glucose-Stimulated Insulin SecretionEvidence for a Role of Oxidative Stress In Vitro and In Vivo
    Andrei I. Oprescu, George Bikopoulos, Anthony Naassan, Emma M. Allister, Christine Tang, Edward Park, Hiroshi Uchino, Gary F. Lewis, I. George Fantus, Maria Rozakis-Adcock, Michael B. Wheeler and Adria Giacca
    Diabetes 2007 Dec; 56 (12): 2927-2937. https://doi.org/10.2337/db07-0075
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    MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
    Francis C. Lynn, Peter Skewes-Cox, Yasuhiro Kosaka, Michael T. McManus, Brian D. Harfe and Michael S. German
    Diabetes 2007 Dec; 56 (12): 2938-2945. https://doi.org/10.2337/db07-0175
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    Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic β-Cell Survival by Activation of the Prosurvival Kinase Akt
    Tatsuya Yano, Zhengyu Liu, Jennifer Donovan, Melissa K. Thomas and Joel F. Habener
    Diabetes 2007 Dec; 56 (12): 2946-2957. https://doi.org/10.2337/db07-0291
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Pathophysiology

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    Hyperinsulinemia Rapidly Increases Human Muscle Microvascular Perfusion but Fails to Increase Muscle Insulin ClearanceEvidence That a Saturable Process Mediates Muscle Insulin Uptake
    Emma M. Eggleston, Linda A. Jahn and Eugene J. Barrett
    Diabetes 2007 Dec; 56 (12): 2958-2963. https://doi.org/10.2337/db07-0670
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    Childhood Predictors of Young-Onset Type 2 Diabetes
    Paul W. Franks, Robert L. Hanson, William C. Knowler, Carol Moffett, Gleebah Enos, Aniello M. Infante, Jonathan Krakoff and Helen C. Looker
    Diabetes 2007 Dec; 56 (12): 2964-2972. https://doi.org/10.2337/db06-1639
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    Essential Role of Mitochondrial Function in Adiponectin Synthesis in Adipocytes
    Eun Hee Koh, Joong-Yeol Park, Hye-Sun Park, Min Jae Jeon, Je Won Ryu, Mina Kim, Sun Young Kim, Min-Seon Kim, Seung-Whan Kim, In Sun Park, Jang Hyun Youn and Ki-Up Lee
    Diabetes 2007 Dec; 56 (12): 2973-2981. https://doi.org/10.2337/db07-0510
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    Thrombospondin-1 Is an Endogenous Activator of TGF-β in Experimental Diabetic Nephropathy In Vivo
    Christoph Daniel, Kathrin Schaub, Kerstin Amann, Jack Lawler and Christian Hugo
    Diabetes 2007 Dec; 56 (12): 2982-2989. https://doi.org/10.2337/db07-0551
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    A 20-Year Prospective Study of Childbearing and Incidence of Diabetes in Young Women, Controlling for Glycemia Before ConceptionThe Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Erica P. Gunderson, Cora E. Lewis, Ai-Lin Tsai, Vicky Chiang, Mercedes Carnethon, Charles P. Quesenberry and Stephen Sidney
    Diabetes 2007 Dec; 56 (12): 2990-2996. https://doi.org/10.2337/db07-1024
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Complications

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    Protective Effects of Cyclooxygenase-2 Gene Inactivation Against Peripheral Nerve Dysfunction and Intraepidermal Nerve Fiber Loss in Experimental Diabetes
    Aaron P. Kellogg, Tim D. Wiggin, Dennis D. Larkin, John M. Hayes, Martin J. Stevens and Rodica Pop-Busui
    Diabetes 2007 Dec; 56 (12): 2997-3005. https://doi.org/10.2337/db07-0740
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Pharmacology and Therapeutics

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    Incretin Receptors for Glucagon-Like Peptide 1 and Glucose-Dependent Insulinotropic Polypeptide Are Essential for the Sustained Metabolic Actions of Vildagliptin in Mice
    Grace Flock, Laurie L. Baggio, Christine Longuet and Daniel J. Drucker
    Diabetes 2007 Dec; 56 (12): 3006-3013. https://doi.org/10.2337/db07-0697
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    The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic PatientsAn Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study
    Joseph DiChiara, Kevin P. Bliden, Udaya S. Tantry, Miruais S. Hamed, Mark J. Antonino, Thomas A. Suarez, Oscar Bailon, Anand Singla and Paul A. Gurbel
    Diabetes 2007 Dec; 56 (12): 3014-3019. https://doi.org/10.2337/db07-0707
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Genetics

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    LPIN2 Is Associated With Type 2 Diabetes, Glucose Metabolism, and Body Composition
    Yurii S. Aulchenko, Jan Pullen, Wigard P. Kloosterman, Mojgan Yazdanpanah, Albert Hofman, Norbert Vaessen, Pieter J.L.M. Snijders, Dmitry Zubakov, Ian Mackay, Mark Olavesen, Balbinder Sidhu, Vicki E. Smith, Alisoun Carey, Eugene Berezikov, André G. Uitterlinden, Ronald H.A. Plasterk, Ben A. Oostra and Cornelia M. van Duijn
    Diabetes 2007 Dec; 56 (12): 3020-3026. https://doi.org/10.2337/db07-0338
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    Variants in the Plasmacytoma Variant Translocation Gene (PVT1) Are Associated With End-Stage Renal Disease Attributed to Type 1 Diabetes
    Meredith P. Millis, Danielle Bowen, Christopher Kingsley, Richard M. Watanabe and Johanna K. Wolford
    Diabetes 2007 Dec; 56 (12): 3027-3032. https://doi.org/10.2337/db07-0675
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    Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-Wide Association Studies
    M. Geoffrey Hayes, Anna Pluzhnikov, Kazuaki Miyake, Ying Sun, Maggie C.Y. Ng, Cheryl A. Roe, Jennifer E. Below, Raluca I. Nicolae, Anuar Konkashbaev, Graeme I. Bell, Nancy J. Cox and Craig L. Hanis
    Diabetes 2007 Dec; 56 (12): 3033-3044. https://doi.org/10.2337/db07-0482
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    A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array
    Robert L. Hanson, Clifton Bogardus, David Duggan, Sayuko Kobes, Michele Knowlton, Aniello M. Infante, Leslie Marovich, Deb Benitez, Leslie J. Baier and William C. Knowler
    Diabetes 2007 Dec; 56 (12): 3045-3052. https://doi.org/10.2337/db07-0462
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    Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order AmishEvidence for Replication From Diabetes-Related Quantitative Traits and From Independent Populations
    Evadnie Rampersaud, Coleen M. Damcott, Mao Fu, Haiqing Shen, Patrick McArdle, Xiaolian Shi, John Shelton, Jing Yin, Yen-Pei C. Chang, Sandra H. Ott, Li Zhang, Yiju Zhao, Braxton D. Mitchell, Jeffery O'Connell and Alan R. Shuldiner
    Diabetes 2007 Dec; 56 (12): 3053-3062. https://doi.org/10.2337/db07-0457
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    A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart StudyReplication and Integration With Other Genome-Wide Datasets
    Jose C. Florez, Alisa K. Manning, Josée Dupuis, Jarred McAteer, Kathryn Irenze, Lauren Gianniny, Daniel B. Mirel, Caroline S. Fox, L. Adrienne Cupples and James B. Meigs
    Diabetes 2007 Dec; 56 (12): 3063-3074. https://doi.org/10.2337/db07-0451
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    Interleukin-6 Receptor Gene Variations, Plasma Interleukin-6 Levels, and Type 2 Diabetes in U.S. Women
    Lu Qi, Nader Rifai and Frank B. Hu
    Diabetes 2007 Dec; 56 (12): 3075-3081. https://doi.org/10.2337/db07-0505
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    TCF7L2 Is Not a Major Susceptibility Gene for Type 2 Diabetes in Pima IndiansAnalysis of 3,501 Individuals
    Tingwei Guo, Robert L. Hanson, Michael Traurig, Yunhua Li Muller, Lijun Ma, Janel Mack, Sayuko Kobes, William C. Knowler, Clifton Bogardus and Leslie J. Baier
    Diabetes 2007 Dec; 56 (12): 3082-3088. https://doi.org/10.2337/db07-0621
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    Variants in the Cav2.3 (α1E) Subunit of Voltage-Activated Ca2+ Channels Are Associated With Insulin Resistance and Type 2 Diabetes in Pima Indians
    Yunhua Li Muller, Robert L. Hanson, Collin Zimmerman, Inge Harper, Jeff Sutherland, Sayuko Kobes, William C. Knowler, Clifton Bogardus and Leslie J. Baier
    Diabetes 2007 Dec; 56 (12): 3089-3094. https://doi.org/10.2337/db07-0587
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    Effects of Genetic Variation in the Human Retinol Binding Protein-4 Gene (RBP4) on Insulin Resistance and Fat Depot–Specific mRNA Expression
    Peter Kovacs, Michaela Geyer, Janin Berndt, Nora Klöting, Timothy E. Graham, Yvonne Böttcher, Beate Enigk, Anke Tönjes, Dorit Schleinitz, Michael R. Schön, Barbara B. Kahn, Matthias Blüher and Michael Stumvoll
    Diabetes 2007 Dec; 56 (12): 3095-3100. https://doi.org/10.2337/db06-1647
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    Common Variants of the Novel Type 2 Diabetes Genes CDKAL1 and HHEX/IDE Are Associated With Decreased Pancreatic β-Cell Function
    Laura Pascoe, Andrea Tura, Sheila K. Patel, Ibrahim M. Ibrahim, Ele Ferrannini, Eleftheria Zeggini, Michael N. Weedon, Andrea Mari, Andrew T. Hattersley, Mark I. McCarthy, Timothy M. Frayling and Mark Walker
    Diabetes 2007 Dec; 56 (12): 3101-3104. https://doi.org/10.2337/db07-0634
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    Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2 Genes With Type 2 Diabetes and Impaired Insulin Release in 10,705 Danish SubjectsValidation and Extension of Genome-Wide Association Studies
    Niels Grarup, Chrisian S. Rose, Ehm A. Andersson, Gitte Andersen, Arne L. Nielsen, Anders Albrechtsen, Jesper O. Clausen, Signe S. Rasmussen, Torben Jørgensen, Annelli Sandbæk, Torsten Lauritzen, Ole Schmitz, Torben Hansen and Oluf Pedersen
    Diabetes 2007 Dec; 56 (12): 3105-3111. https://doi.org/10.2337/db07-0856
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    Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4α (HNF4A) P2 Region Are Associated With Type 2 Diabetes in Scandinavians
    Stefan Johansson, Helge Ræder, Stig Å Eide, Kristian Midthjell, Kristian Hveem, Oddmund Søvik, Anders Molven and Pål Rasmus Njølstad
    Diabetes 2007 Dec; 56 (12): 3112-3117. https://doi.org/10.2337/db07-0513
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Online Letters to the Editor

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    Comment on: Cani et al. (2007) Metabolic Endotoxemia Initiates Obesity and Insulin Resistance: Diabetes 56:1761–1772
    Toshiyuki Saito, Hideaki Hayashida and Reiko Furugen
    Diabetes 2007 Dec; 56 (12): e20. https://doi.org/10.2337/db07-1181
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    Response to Comment on: Cani et al. (2007) Metabolic Endotoxemia Initiates Obesity and Insulin Resistance: Diabetes 56:1761–1772
    Rémy Burcelin, Patrice D. Cani and Jacques Amar
    Diabetes 2007 Dec; 56 (12): e21. https://doi.org/10.2337/db07-1262
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    Comment on: Chang et al. (2007) Association Study of the Genetic Polymorphisms of the Transcription Factor 7-like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population: Diabetes 56:2631–2637
    Chee-Seng Ku, Moira Khaw and Kee Seng Chia
    Diabetes 2007 Dec; 56 (12): e22. https://doi.org/10.2337/db07-1213
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    Response to Comment on: Chang et al. (2007) Association Study of the Genetic Polymorphisms of the Transcription Factor 7-like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population: Diabetes 56:2631–2637
    Yi-Cheng Chang, Ken C. Chiu and Lee-Ming Chuang
    Diabetes 2007 Dec; 56 (12): e23. https://doi.org/10.2337/db07-1302
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December 2007, 56(12)
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