Skip to main content
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • My Cart
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in
  • My Cart

Search

  • Advanced search
Diabetes
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Immunology and Transplantation

Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice

  1. Suzanne D. Burke,
  2. Hongmei Dong,
  3. Aleah D. Hazan and
  4. B. Anne Croy
  1. From the Department of Anatomy and Cell Biology, Queen’s University, Kingston, Ontario, Canada
  1. Address correspondence and reprint requests to Suzanne Burke, Department of Anatomy and Cell Biology, Queen’s University, Kingston, Ontario, Canada K7L 3N6. E-mail: 5sb28{at}queensu.ca
Diabetes 2007 Dec; 56(12): 2919-2926. https://doi.org/10.2337/db07-0773
PreviousNext
  • Article
  • Figures & Tables
  • Info & Metrics
  • PDF
Loading

Article Figures & Tables

Figures

  • Tables
  • FIG. 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG. 1.

    Blood glucose values of mated NOD mice. Mice were classified as normoglycemic (n = 5; ▪; <11 mmol/l), pre-diabetic (n = 7; ▴; >11.1–14.9 mmol/l), or diabetic (n = 7; ♦; >15 mmol/l) based on values measured at gd10. Pregnancy elevated blood glucose values in all animals, with the largest increase in diabetic mice before conception. Diabetic NOD mice showed an increase in blood glucose from three previous measurements (P < 0.005).

  • FIG. 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG. 2.

    A litter of gd18 fetuses born to an overtly diabetic NOD dam. Three neural tube defects and widely variable fetal size were noted. At necropsy, only 50% had the potential to survive, all exhibited congenital defects.

  • FIG. 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG. 3.

    uNK cell counts within the (A) MLAp and (B) decidua basalis of NOD.scid, normoglycemic, pre-diabetic, and diabetic NOD implantation sites. *P < 0.05 compared with NOD.scid implantation sites. **P < 0.001 compared with normoglycemic and pre-diabetic NOD implantation sites. Data are means ± SE from n = 3 mice per group (three viable implantation sites per mouse).

  • FIG. 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG. 4.

    A: Spiral artery lumen diameter (μm) in NOD.scid, normoglycemic, pre-diabetic, and diabetic NOD mice at gd10. B: Wall-to-lumen ratios of spiral arteries in NOD.scid, normoglycemic, pre-diabetic, and diabetic implantation sites. All groups are significantly different (P < 0.05), except for NOD.scid versus normoglycemic NOD mice. Data are means ± SE from n = 3 mice per group (three viable implantation sites per mouse).

  • FIG. 5.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG. 5.

    Representative VCAM-1 staining in gd8 mouse tissues. Endothelium in vessels of decidua basalis consistently appeared more reactive in B6 mice (arrow) (A) than in diabetic NOD mice (arrow) (B). Pancreatic islets of B6 mice were unreactive (C) but were strongly reactive in diabetic NOD mice (arrow) (D). The latter showed leukocyte infiltration (arrowhead), consistent with insulitis observed in overt diabetes. Tissues illustrated are from paired single donors. Counterstained with hematoxylin. Bar = 20 μm. (Please see http://dx.doi.org/10.2337/db07-0773 for a high-quality digital representation of this figure.)

  • FIG. 6.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG. 6.

    Human CD56+ cells bound to peripheral lymph node from B6, normoglycemic NOD, pre-diabetic NOD, or diabetic NOD mice per high-powered field (×400 magnification). Data are presented from replicate experiments using the same blood donor. *P < 0.05 vs. B6, **P < 0.05 vs. B6 and diabetic NOD mice.

  • FIG. 7.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG. 7.

    FITC-DX5+ splenic NK cells (A) or DX5+/CMAC+ splenic NK/lymphocytes (B) bound to peripheral lymph node, pancreas, or gd7 uterus from normal B6 mice per high-powered field (×400 magnification). Splenocyte donors are B6, normoglycemic NOD, or diabetic NOD mice. *P < 0.05 vs. B6, **P < 0.05 vs. B6 and normoglycemic NOD splenocyte binding.

Tables

  • Figures
  • TABLE 1

    Fetal loss rate in NOD mice

    Blood glucose at gd10Number of damsTotal embryos% Resorption
    NOD.scid9.63316.3
    Normoglycemic NOD10.23324.0
    Pre-diabetic NOD13.36719.5
    Diabetic NOD26.9*44030.3†
    • *

      * P < 0.0005,

    • †

      † P = 0.021 compared with pre-diabetic, normoglycemic, and NOD.scid mice.

PreviousNext
Back to top

In this Issue

December 2007, 56(12)
  • Table of Contents
  • Index by Author
Sign up to receive current issue alerts
View Selected Citations (0)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice
(Your Name) has forwarded a page to you from Diabetes
(Your Name) thought you would like to see this page from the Diabetes web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice
Suzanne D. Burke, Hongmei Dong, Aleah D. Hazan, B. Anne Croy
Diabetes Dec 2007, 56 (12) 2919-2926; DOI: 10.2337/db07-0773

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice
Suzanne D. Burke, Hongmei Dong, Aleah D. Hazan, B. Anne Croy
Diabetes Dec 2007, 56 (12) 2919-2926; DOI: 10.2337/db07-0773
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • RESEARCH DESIGN AND METHODS
    • RESULTS
    • DISCUSSION
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Tables
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent-Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24
  • Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
  • Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes
Show more Immunology and Transplantation

Similar Articles

Navigate

  • Current Issue
  • Online Ahead of Print
  • Scientific Sessions Abstracts
  • Collections
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • Advertising
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes Care
  • Clinical Diabetes
  • Diabetes Spectrum
  • Scientific Sessions Abstracts
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org

© 2021 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.