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Table of Contents

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April 01 2007; volume 56 issue 4

Obesity Studies

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    Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
    Naomi Hosogai, Atsunori Fukuhara, Kazuya Oshima, Yugo Miyata, Sachiyo Tanaka, Katsumori Segawa, Shigetada Furukawa, Yoshihiro Tochino, Ryutaro Komuro, Morihiro Matsuda and Iichiro Shimomura
    Diabetes 2007 Apr; 56 (4): 901-911. https://doi.org/10.2337/db06-0911
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    Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production
    Emmanuel Chevillotte, Marta Giralt, Bruno Miroux, Daniel Ricquier and Francesc Villarroya
    Diabetes 2007 Apr; 56 (4): 1042-1050. https://doi.org/10.2337/db06-1300
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    Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats
    Deborah J. Clegg, Lynda M. Brown, Jeffrey M. Zigman, Christopher J. Kemp, April D. Strader, Stephen C. Benoit, Stephen C. Woods, Michela Mangiaracina and Nori Geary
    Diabetes 2007 Apr; 56 (4): 1051-1058. https://doi.org/10.2337/db06-0015
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Immunology and Transplantation

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    Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21A Novel Strategy to Prolong Islet Allograft Survival
    Paolo Fiorina, Mollie Jurewicz, Katsunori Tanaka, Negin Behazin, Andrea Augello, Andrea Vergani, Uli Von Adrian, Neal R. Smith, Mohamed H. Sayegh and Reza Abdi
    Diabetes 2007 Apr; 56 (4): 912-920. https://doi.org/10.2337/db06-1445
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    Minimal Impact of a De Novo–Expressed β-Cell Autoantigen on Spontaneous Diabetes Development in NOD Mice
    Marianne M. Martinic, Amy E. Juedes, Damien Bresson, Dirk Homann, Kresten Skak, Christoph Huber, Eleanor Ling, Mette Ejrnaes, Tom Wolfe, Lisa Togher, Urs Christen and Matthias G. von Herrath
    Diabetes 2007 Apr; 56 (4): 1059-1068. https://doi.org/10.2337/db05-0062
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Islet Studies

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    Insulin-Expressing Colonies Developed From Murine Embryonic Stem Cell–Derived Progenitors
    Hsun Teresa Ku, Jing Chai, Yoon-Jung Kim, Peter White, Sheetal Purohit-Ghelani, Klaus H. Kaestner and Jonathan S. Bromberg
    Diabetes 2007 Apr; 56 (4): 921-929. https://doi.org/10.2337/db06-0468
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    Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy
    Natalia A. Kaniuk, Michael Kiraly, Holly Bates, Mladen Vranic, Allen Volchuk and John H. Brumell
    Diabetes 2007 Apr; 56 (4): 930-939. https://doi.org/10.2337/db06-1160
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    Phenotype and Functional Characteristics of Islet-Infiltrating B-Cells Suggest the Existence of Immune Regulatory Mechanisms in Islet Milieu
    Maria Carmen Puertas, Jorge Carrillo, Xavier Pastor, Rosa Maria Ampudia, Aurora Alba, Raquel Planas, Ricardo Pujol-Borrell, Marta Vives-Pi and Joan Verdaguer
    Diabetes 2007 Apr; 56 (4): 940-949. https://doi.org/10.2337/db06-0428
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    Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas
    Aouatef Ait-Lounis, Dominique Baas, Emmanuèle Barras, Carine Benadiba, Anne Charollais, Rachel Nlend Nlend, Delphine Liègeois, Paolo Meda, Bénédicte Durand and Walter Reith
    Diabetes 2007 Apr; 56 (4): 950-959. https://doi.org/10.2337/db06-1187
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    Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells
    Pierre Pirot, Fernanda Ortis, Miriam Cnop, Yanjun Ma, Linda M. Hendershot, Décio L. Eizirik and Alessandra K. Cardozo
    Diabetes 2007 Apr; 56 (4): 1069-1077. https://doi.org/10.2337/db06-1253
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    Cx36-Mediated Coupling Reduces β-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics
    Stephan Speier, Asllan Gjinovci, Anne Charollais, Paolo Meda and Marjan Rupnik
    Diabetes 2007 Apr; 56 (4): 1078-1086. https://doi.org/10.2337/db06-0232
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    GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo
    Martin G. Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L. Jetton, Jian Luo, Daniel C.-H. Lin and Vincent Poitout
    Diabetes 2007 Apr; 56 (4): 1087-1094. https://doi.org/10.2337/db06-1532
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    Effects of Diazoxide on Gene Expression in Rat Pancreatic Islets Are Largely Linked to Elevated Glucose and Potentially Serve to Enhance β-Cell Sensitivity
    Zuheng Ma, Neil Portwood, David Brodin, Valdemar Grill and Anneli Björklund
    Diabetes 2007 Apr; 56 (4): 1095-1106. https://doi.org/10.2337/db06-0322
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    Zinc, Not Insulin, Regulates the Rat α-Cell Response to Hypoglycemia In Vivo
    Huarong Zhou, Tao Zhang, Jamie S. Harmon, Joseph Bryan and R. Paul Robertson
    Diabetes 2007 Apr; 56 (4): 1107-1112. https://doi.org/10.2337/db06-1454
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Complications

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    Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells
    Sergio Caballero, Nilanjana Sengupta, Aqeela Afzal, Kyung-Hee Chang, Sergio Li Calzi, Dennis L. Guberski, Timothy S. Kern and Maria B. Grant
    Diabetes 2007 Apr; 56 (4): 960-967. https://doi.org/10.2337/db06-1254
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    Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes
    Richard J.M. Coward, Gavin I. Welsh, Ania Koziell, Sagair Hussain, Rachel Lennon, Lan Ni, Jeremy M. Tavaré, Peter W. Mathieson and Moin A. Saleem
    Diabetes 2007 Apr; 56 (4): 1127-1135. https://doi.org/10.2337/db06-0693
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    Effects of Palmitate on Ca2+ Handling in Adult Control and ob/ob Cardiomyocytes Impact of Mitochondrial Reactive Oxygen Species
    Jérémy Fauconnier, Daniel C. Andersson, Shi-Jin Zhang, Johanna T. Lanner, Rolf Wibom, Abram Katz, Joseph D. Bruton and Håkan Westerblad
    Diabetes 2007 Apr; 56 (4): 1136-1142. https://doi.org/10.2337/db06-0739
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    Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated Receptor-γ–Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages
    Bardia Askari, Jenny E. Kanter, Ashley M. Sherrid, Deidre L. Golej, Andrew T. Bender, Joey Liu, Willa A. Hsueh, Joseph A. Beavo, Rosalind A. Coleman and Karin E. Bornfeldt
    Diabetes 2007 Apr; 56 (4): 1143-1152. https://doi.org/10.2337/db06-0267
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Pharmacology and Therapeutics

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    Renal Effects of S18886 (Terutroban), a TP Receptor Antagonist, in an Experimental Model of Type 2 Diabetes
    Katarína Šebeková, Timo Eifert, André Klassen, August Heidland and Kerstin Amann
    Diabetes 2007 Apr; 56 (4): 968-974. https://doi.org/10.2337/db06-1136
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    Factors Associated With Diabetes Onset During Metformin Versus Placebo Therapy in the Diabetes Prevention Program
    John M. Lachin, Costas A. Christophi, Sharon L. Edelstein, David A. Ehrmann, Richard F. Hamman, Steven E. Kahn, William C. Knowler and David M. Nathan
    Diabetes 2007 Apr; 56 (4): 1153-1159. https://doi.org/10.2337/db06-0918
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Genetics

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    Identification of PVT1 as a Candidate Gene for End-Stage Renal Disease in Type 2 Diabetes Using a Pooling-Based Genome-Wide Single Nucleotide Polymorphism Association Study
    Robert L. Hanson, David W. Craig, Meredith P. Millis, Kimberly A. Yeatts, Sayuko Kobes, John V. Pearson, Anne M. Lee, William C. Knowler, Robert G. Nelson and Johanna K. Wolford
    Diabetes 2007 Apr; 56 (4): 975-983. https://doi.org/10.2337/db06-1072
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    Genome-Wide Linkage Analyses to Identify Loci for Diabetic Retinopathy
    Helen C. Looker, Robert G. Nelson, Emily Chew, Ronald Klein, Barbara E.K. Klein, William C. Knowler and Robert L. Hanson
    Diabetes 2007 Apr; 56 (4): 1160-1166. https://doi.org/10.2337/db06-1299
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    A Genome-Wide Linkage Scan for Diabetic Retinopathy Susceptibility Genes in Mexican Americans With Type 2 Diabetes From Starr County, Texas
    D. Michael Hallman, Eric Boerwinkle, Victor H. Gonzalez, Barbara E. K. Klein, Ronald Klein and Craig L. Hanis
    Diabetes 2007 Apr; 56 (4): 1167-1173. https://doi.org/10.2337/db06-1373
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Metabolism

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    Serial Metabolic Measurements and Conversion to Type 2 Diabetes in the West of Scotland Coronary Prevention StudySpecific Elevations in Alanine Aminotransferase and Triglycerides Suggest Hepatic Fat Accumulation as a Potential Contributing Factor
    Naveed Sattar, Alex McConnachie, Ian Ford, Allan Gaw, Stephen J. Cleland, Nita G. Forouhi, Peter McFarlane, James Shepherd, Stuart Cobbe and Chris Packard
    Diabetes 2007 Apr; 56 (4): 984-991. https://doi.org/10.2337/db06-1256
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    Acute Hyperglycemia Induces a Global Downregulation of Gene Expression in Adipose Tissue and Skeletal Muscle of Healthy Subjects
    Emmanuelle Meugnier, May Faraj, Sophie Rome, Geneviève Beauregard, Angélique Michaut, Véronique Pelloux, Jean-Louis Chiasson, Martine Laville, Karine Clement, Hubert Vidal and Rémi Rabasa-Lhoret
    Diabetes 2007 Apr; 56 (4): 992-999. https://doi.org/10.2337/db06-1242
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    Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1
    Yasuo Okamoto, Wataru Ogawa, Akihiko Nishizawa, Hiroshi Inoue, Kiyoshi Teshigawara, Shinichi Kinoshita, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue, Tetsuo Noda and Masato Kasuga
    Diabetes 2007 Apr; 56 (4): 1000-1009. https://doi.org/10.2337/db06-1322
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    Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans
    Luigi Fontana, J. Christopher Eagon, Maria E. Trujillo, Philipp E. Scherer and Samuel Klein
    Diabetes 2007 Apr; 56 (4): 1010-1013. https://doi.org/10.2337/db06-1656
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Signal Transduction

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    Defective Insulin and Acetylcholine Induction of Endothelial Cell–Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats
    Henrique G. Zecchin, Fernanda B.M. Priviero, Claudio T. Souza, Karina G. Zecchin, Patrícia O. Prada, José B.C. Carvalheira, Licio A. Velloso, Edson Antunes and Mario J.A. Saad
    Diabetes 2007 Apr; 56 (4): 1014-1024. https://doi.org/10.2337/db05-1147
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    Chronic Treatment With Sildenafil Improves Energy Balance and Insulin Action in High Fat–Fed Conscious Mice
    Julio E. Ayala, Deanna P. Bracy, Brianna M. Julien, Jeffrey N. Rottman, Patrick T. Fueger and David H. Wasserman
    Diabetes 2007 Apr; 56 (4): 1025-1033. https://doi.org/10.2337/db06-0883
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    n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner
    Susanne Neschen, Katsutaro Morino, Jianying Dong, Yanlin Wang-Fischer, Gary W. Cline, Anthony J. Romanelli, Jörg C. Rossbacher, Irene K. Moore, Werner Regittnig, David S. Munoz, Jung H. Kim and Gerald I. Shulman
    Diabetes 2007 Apr; 56 (4): 1034-1041. https://doi.org/10.2337/db06-1206
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Pathophysiology

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    Effects of Nonglucose Nutrients on Insulin Secretion and Action in People With Pre-Diabetes
    Gerlies Bock, Chiara Dalla Man, Marco Campioni, Elizabeth Chittilapilly, Rita Basu, Gianna Toffolo, Claudio Cobelli and Robert Rizza
    Diabetes 2007 Apr; 56 (4): 1113-1119. https://doi.org/10.2337/db06-1272
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    ATP-Sensitive K+ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia
    Owen Chan, Marcus Lawson, Wanling Zhu, Joseph Lee Beverly and Robert S. Sherwin
    Diabetes 2007 Apr; 56 (4): 1120-1126. https://doi.org/10.2337/db06-1102
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Brief Reports

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    Toward Further Mapping of the Association Between the IL2RA Locus and Type 1 Diabetes
    Hui-Qi Qu, Alexander Montpetit, Bing Ge, Thomas J. Hudson and Constantin Polychronakos
    Diabetes 2007 Apr; 56 (4): 1174-1176. https://doi.org/10.2337/db06-1555
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    SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes
    Hsing-Yi Lin, Chiao-Ling Wang, Pi-Jung Hsiao, Yung-Chuan Lu, Su-Yu Chen, Kun-Der Lin, Shih-Chie Hsin, Ming-Chia Hsieh and Shyi-Jang Shin
    Diabetes 2007 Apr; 56 (4): 1177-1180. https://doi.org/10.2337/db06-1283
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    Single Nucleotide Polymorphisms of the Peroxisome Proliferator–Activated Receptor-α Gene (PPARA) Influence the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes The STOP-NIDDM Trial
    Laura Andrulionytė, Teemu Kuulasmaa, Jean-Louis Chiasson and Markku Laakso
    Diabetes 2007 Apr; 56 (4): 1181-1186. https://doi.org/10.2337/db06-1110
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April 2007, 56(4)
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  • Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
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  • A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels
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