(How) Can We Prevent Type 2 Diabetes?
- Thomas A. Buchanan
- From the Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California
- Address correspondence and reprint requests to Thomas A. Buchanan, MD, Room 6602, General Hospital, 1200 N. State St., Los Angeles, CA 90033. E-mail: buchanan{at}usc.edu
Article Figures & Tables
Figures
- FIG. 1.
Schematic representation of two interventions that would lead to a reduction in diabetes incidence rates in a clinical trial. Stepped lines represent cumulative incidence rates based on intermittent testing for diabetes. Straight lines are slopes of the cumulative incidence curves during and after treatment. Inserts depict the absolute risk reductions (fraction of cases in control − fraction of cases in intervention group) at intervals indicated by arrows along the x-axis. A: Intervention that slows rates of deterioration during treatment. Slopes are different during treatment and, following withdrawal of treatment, remain parallel. The difference in cumulative incidence rates achieved during treatment persists. B: Intervention that lowers glucose levels during treatment without altering their rate of deterioration. Slopes are parallel during treatment and, following withdrawal of treatment, cumulative incidence curves converge.
- FIG. 2.
Annual absolute risk reductions in intervention groups compared with control groups during treatment in six studies using six different interventions for diabetes prevention in high-risk individuals. Interventions appear below study acronyms. Plots were made using data from the figures in the publications describing the primary trial results (1–6).
