Quantitative Trait Loci for Fasting Glucose in Young Europeans Replicate Previous Findings for Type 2 Diabetes in 2q23–24 and Other Locations

Brief Reports

¹Department of Pediatric Endocrinology, Hôpital Saint-Vincent de Paul and U561 Institut National de la Santé et de la Recherche Médicale, Paris, France
²Centre National de Génotypage, Evry, France
³Equipe d'Accueil University Paris V, Paris, France

Address correspondence and reprint requests to Delphine Fradin, INSERM U561, Hôpital Saint Vincent de Paul, 82 Avenue Denfert Rochereau, 75014 Paris, France. E-mail: fradin{at}paris5.inserm.fr

Diabetes 2007 Jun; 56(6): 1742-1745. https://doi.org/10.2337/db06-1329

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FIG. 1.
Graph of the multipoint LOD scores from the genome-wide scan in the 412 Caucasians sibling pairs with 418 DNA markers, using the variance component analysis. The x-axis represents few markers in all autosomes, whereas the y-axis represents the multipoint LOD score.

TABLE 1

Regions displaying multipoint LOD scores ≥1 in the current cohort and other studies of fasting glucose or type 2 diabetes

LOD scores for fasting glucose
Chr.	Markers	Regions	Nonadjusted	Adjusted for age and sex	Adjusted for age, sex, and BMI	Candidate genes
2	D2S367	2p21	1.00			PRKCE, SOS1, ARHQ
	D2S2259	2p16	1.15
	D2S142	2q23	1.78	2.07	3.00	GPD2, IGRP
	D2S2330	2q24.1	1.61	2.00	1.98
6	D6S257	6p12–p11	1.11
7	D7S640	7q33	1.66	1.18
	D7S684	7q34	2.09	2.03	2.03
	D7S661	7q35	1.58	1.39	1.70
8	D8S514	8q24.13	1.66	1.66	1.28
11	D11S4046	11p15.5	2.02	1.99	1.33	SUR, Kir6.2, INS
	D11S1338	11p15.5	1.68	1.44
	D11S902	11p15–p13	1.41
	D11S904	11p14–p13	1.25	1.02
	D11S4191	11p13–q11	1.28	1.30
	D11S1314	11q13–q14	1.49	1.35
	D11S937	11q13–q14	1.27
17	D17S831	17p13.3			2.12	GLUT4
	D17S798	17q12			1.40

Results from other studies
LOD scores	Phenotypes and populations	Reference
2.28 at 2p21–p16	Type 2 diabetes in Europeans	Vionnet et al. (15)
1.25 at 2q23–q24	Type 2 diabetes in Europeans	Vionnet et al. (15)
2.61 at 2q24	Type 2 diabetes in Australians	Busfield et al. (16)
1.41 at 8q24	Type 2 diabetes in the U.K.	Wiltshire et al. (17)
0.9 at 11p15.1	Type 2 diabetes in the Netherlands	Van Tilburg et al. (18)
11p15.1	Fasting glucose in the Framingham Heart Study	Chen et al. (25)

ARHQ, Ras homolog gene family, member Q; Chr., chromosome; GPD2, mitochondrial glycerophosphate dehyfrogenase; IGRP, islet-specific glucose-6-phosphate catalytic subunit–related protein; INS, insulin; PRKCE, protein kinase C epsilo; SOS1, son of sevenless drosophila homolog 1; SUR, sulfonylurea receptor.