Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

Daniela M.L. Tsukumo; Marco A. Carvalho-Filho; José B.C. Carvalheira; Patrícia O. Prada; Sandro M. Hirabara; André A. Schenka; Eliana P. Araújo; José Vassallo; Rui Curi; Lício A. Velloso; Mario J.A. Saad

doi:10.2337/db06-1595

Obesity Studies

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

Daniela M.L. Tsukumo1,
Marco A. Carvalho-Filho1,
José B.C. Carvalheira1,
Patrícia O. Prada1,
Sandro M. Hirabara2,
André A. Schenka3,
Eliana P. Araújo1,
José Vassallo3,
Rui Curi2,
Lício A. Velloso1 and
Mario J.A. Saad1

¹Department of Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
²Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
³Department of Pathology, State University of Campinas, Campinas, São Paulo, Brazil

Address correspondence and reprint requests to Mario J.A. Saad, MD, Departamento de Clínica Médica, FCM-UNICAMP, Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil, 13081-970. E-mail: msaad{at}fcm.unicamp.br

Diabetes 2007 Aug; 56(8): 1986-1998. https://doi.org/10.2337/db06-1595

Article Information

vol. 56 no. 8 1986-1998

DOI

https://doi.org/10.2337/db06-1595

PubMed

17519423

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Received November 14, 2006
Accepted May 18, 2007
Published in print July 27, 2007.
Published online ahead of print May 22, 2007.

Article Versions

Previous version (May 22, 2007 - 13:23).
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DIABETES

Author Information

Daniela M.L. Tsukumo1,
Marco A. Carvalho-Filho1,
José B.C. Carvalheira1,
Patrícia O. Prada1,
Sandro M. Hirabara2,
André A. Schenka3,
Eliana P. Araújo1,
José Vassallo3,
Rui Curi2,
Lício A. Velloso1 and
Mario J.A. Saad1

¹Department of Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
²Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
³Department of Pathology, State University of Campinas, Campinas, São Paulo, Brazil

Address correspondence and reprint requests to Mario J.A. Saad, MD, Departamento de Clínica Médica, FCM-UNICAMP, Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil, 13081-970. E-mail: msaad{at}fcm.unicamp.br

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