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Obesity Studies

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

  1. Daniela M.L. Tsukumo1,
  2. Marco A. Carvalho-Filho1,
  3. José B.C. Carvalheira1,
  4. Patrícia O. Prada1,
  5. Sandro M. Hirabara2,
  6. André A. Schenka3,
  7. Eliana P. Araújo1,
  8. José Vassallo3,
  9. Rui Curi2,
  10. Lício A. Velloso1 and
  11. Mario J.A. Saad1
  1. 1Department of Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
  2. 2Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
  3. 3Department of Pathology, State University of Campinas, Campinas, São Paulo, Brazil
  1. Address correspondence and reprint requests to Mario J.A. Saad, MD, Departamento de Clínica Médica, FCM-UNICAMP, Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil, 13081-970. E-mail: msaad{at}fcm.unicamp.br
Diabetes 2007 Aug; 56(8): 1986-1998. https://doi.org/10.2337/db06-1595
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Article Information

vol. 56 no. 8 1986-1998
DOI 
https://doi.org/10.2337/db06-1595
PubMed 
17519423

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received November 14, 2006
  • Accepted May 18, 2007
  • Published in print July 27, 2007.
  • Published online ahead of print May 22, 2007.

Article Versions

  • Previous version (May 22, 2007 - 13:23).
  • You are viewing the most recent version of this article.
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DIABETES

Author Information

  1. Daniela M.L. Tsukumo1,
  2. Marco A. Carvalho-Filho1,
  3. José B.C. Carvalheira1,
  4. Patrícia O. Prada1,
  5. Sandro M. Hirabara2,
  6. André A. Schenka3,
  7. Eliana P. Araújo1,
  8. José Vassallo3,
  9. Rui Curi2,
  10. Lício A. Velloso1 and
  11. Mario J.A. Saad1
  1. 1Department of Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
  2. 2Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
  3. 3Department of Pathology, State University of Campinas, Campinas, São Paulo, Brazil
  1. Address correspondence and reprint requests to Mario J.A. Saad, MD, Departamento de Clínica Médica, FCM-UNICAMP, Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil, 13081-970. E-mail: msaad{at}fcm.unicamp.br
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Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Daniela M.L. Tsukumo, Marco A. Carvalho-Filho, José B.C. Carvalheira, Patrícia O. Prada, Sandro M. Hirabara, André A. Schenka, Eliana P. Araújo, José Vassallo, Rui Curi, Lício A. Velloso, Mario J.A. Saad
Diabetes Aug 2007, 56 (8) 1986-1998; DOI: 10.2337/db06-1595

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Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Daniela M.L. Tsukumo, Marco A. Carvalho-Filho, José B.C. Carvalheira, Patrícia O. Prada, Sandro M. Hirabara, André A. Schenka, Eliana P. Araújo, José Vassallo, Rui Curi, Lício A. Velloso, Mario J.A. Saad
Diabetes Aug 2007, 56 (8) 1986-1998; DOI: 10.2337/db06-1595
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Keywords

CLS, crown-like structure
ELISA, enzyme-linked immunosorbent assay
FFA, free fatty acid
HFD, high-fat diet
IGTT, intraperitoneal glucose tolerance test
IκBα, inhibitor of nuclear factor-κB
IKKβ, IκB kinase complex
IL, interleukin
IR, insulin receptor
IRS-1, insulin receptor substrate-1
JNK, c-Jun NH2-terminal kinase
LPS, lipopolysaccharide
NK-κB, nuclear factor-κB
RER, respiratory exchange ratio
TNF, tumor necrosis factor
TLR, Toll-like receptor
WAT, white adipose tissue

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  • Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
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