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Signal Transduction

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance

The Medical Research Council Ely Prospective Study 1990–2000

  1. Nita G. Forouhi1,
  2. Jian'an Luan1,
  3. Andrew Cooper1,
  4. Barbara J. Boucher2 and
  5. Nicholas J. Wareham1
  1. 1Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, U.K
  2. 2Centre for Diabetes and Metabolic Medicine, Bart's and the London School of Medicine and Dentistry, London, U.K
  1. Corresponding author: Dr. Nita Gandhi Forouhi, nf250{at}medschl.cam.ac.uk
Diabetes 2008 Oct; 57(10): 2619-2625. https://doi.org/10.2337/db08-0593
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The Medical Research Council Ely Prospective Study 1990–2000

Abstract

OBJECTIVE—Accumulating epidemiological evidence suggests that hypovitaminosis D may be associated with type 2 diabetes and related metabolic risks. However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study.

RESEARCH DESIGN AND METHODS—A total of 524 randomly selected nondiabetic men and women, aged 40–69 years at baseline, with measurements for serum 25(OH)D and IGF-1 in the population-based Ely Study, had glycemic status (oral glucose tolerance), lipids, insulin, anthropometry, and blood pressure measured and metabolic syndrome risk (metabolic syndrome z score) derived at baseline and at 10 years of follow-up.

RESULTS—Age-adjusted baseline mean serum 25(OH)D was greater in men (64.5 nmol/l [95% CI 61.2–67.9]) than women (57.2 nmol/l [54.4,60.0]) and varied with season (highest late summer). Baseline 25(OH)D was associated inversely with 10-year risk of hyperglycemia (fasting glucose: β = −0.0023, P = 0.019; 2-h glucose: β = −0.0097, P = 0.006), insulin resistance (fasting insulin β = −0.1467, P = 0.010; homeostasis model assessment of insulin resistance [HOMA-IR]: β = −0.0059, P = 0.005), and metabolic syndrome z score (β = −0.0016, P = 0.048) after adjustment for age, sex, smoking, BMI, season, and baseline value of each metabolic outcome variable. Associations with 2-h glucose, insulin, and HOMA-IR remained significant after further adjustment for IGF-1, parathyroid hormone, calcium, physical activity, and social class.

CONCLUSIONS—This prospective study reports inverse associations between baseline serum 25(OH)D and future glycemia and insulin resistance. These associations are potentially important in understanding the etiology of abnormal glucose metabolism and warrant investigation in larger, specifically designed prospective studies and randomized controlled trials of supplementation.

Footnotes

  • Published ahead of print at http://diabetes.diabetesjournals.org on 30 June 2008.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    See accompanying commentary, p. 2565.

    • Accepted June 20, 2008.
    • Received May 1, 2008.
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Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
Nita G. Forouhi, Jian'an Luan, Andrew Cooper, Barbara J. Boucher, Nicholas J. Wareham
Diabetes Oct 2008, 57 (10) 2619-2625; DOI: 10.2337/db08-0593

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Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
Nita G. Forouhi, Jian'an Luan, Andrew Cooper, Barbara J. Boucher, Nicholas J. Wareham
Diabetes Oct 2008, 57 (10) 2619-2625; DOI: 10.2337/db08-0593
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