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Table of Contents

PreviousNext

November 01 2008; volume 57 issue 11

Perspectives in Diabetes

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    Viral Trigger for Type 1 DiabetesPros and Cons
    Christophe M. Filippi and Matthias G. von Herrath
    Diabetes 2008 Nov; 57 (11): 2863-2871. https://doi.org/10.2337/db07-1023
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    Primer: Immunity and Autoimmunity
    Massimo Pietropaolo, Julie M. Surhigh, Patrick W. Nelson and George S. Eisenbarth
    Diabetes 2008 Nov; 57 (11): 2872-2882. https://doi.org/10.2337/db07-1691
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    β-Cell Mass and Type 1 DiabetesGoing, Going, Gone?
    Eitan Akirav, Jake A. Kushner and Kevan C. Herold
    Diabetes 2008 Nov; 57 (11): 2883-2888. https://doi.org/10.2337/db07-1817
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    Learning From Molecular GeneticsNovel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes
    Mark I. McCarthy and Andrew T. Hattersley
    Diabetes 2008 Nov; 57 (11): 2889-2898. https://doi.org/10.2337/db08-0343
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    Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner
    Susan Bonner-Weir and Timothy D. O'Brien
    Diabetes 2008 Nov; 57 (11): 2899-2904. https://doi.org/10.2337/db07-1842
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    Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions
    Stephen O'Rahilly and I. Sadaf Farooqi
    Diabetes 2008 Nov; 57 (11): 2905-2910. https://doi.org/10.2337/db08-0210
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Commentaries

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    Public Health Genomics Approach to Type 2 Diabetes
    Muin J. Khoury, Rodolfo Valdez and Ann Albright
    Diabetes 2008 Nov; 57 (11): 2911-2914. https://doi.org/10.2337/db08-1045
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    Genes Associated With Risk of Type 2 Diabetes Identified by a Candidate-Wide Association ScanAs a Trickle Becomes a Flood
    Stephen S. Rich, Jill M. Norris and Jerome I. Rotter
    Diabetes 2008 Nov; 57 (11): 2915-2917. https://doi.org/10.2337/db08-0941
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    An Appreciation of Robert Turner
    Stephen O'Rahilly, Gordon C. Weir and David R. Matthews
    Diabetes 2008 Nov; 57 (11): 2918-2921. https://doi.org/10.2337/db07-1644
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    Big Mac Attack: Does It Play a Direct Role for Monocytes/Macrophages in Type 1 Diabetes?
    Li-Jun Yang
    Diabetes 2008 Nov; 57 (11): 2922-2923. https://doi.org/10.2337/db08-1007
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Metabolism

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    Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3
    Heiko Bugger, Sihem Boudina, Xiao Xuan Hu, Joseph Tuinei, Vlad G. Zaha, Heather A. Theobald, Ui Jeong Yun, Alfred P. McQueen, Benjamin Wayment, Sheldon E. Litwin and E. Dale Abel
    Diabetes 2008 Nov; 57 (11): 2924-2932. https://doi.org/10.2337/db08-0079
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    Endurance Exercise as a Countermeasure for Aging
    Ian R. Lanza, Daniel K. Short, Kevin R. Short, Sreekumar Raghavakaimal, Rita Basu, Michael J. Joyner, Joseph P. McConnell and K. Sreekumaran Nair
    Diabetes 2008 Nov; 57 (11): 2933-2942. https://doi.org/10.2337/db08-0349
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    Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
    Esther Phielix, Vera B. Schrauwen-Hinderling, Marco Mensink, Ellen Lenaers, Ruth Meex, Joris Hoeks, Marianne Eline Kooi, Esther Moonen-Kornips, Jean-Pierre Sels, Matthijs K.C. Hesselink and Patrick Schrauwen
    Diabetes 2008 Nov; 57 (11): 2943-2949. https://doi.org/10.2337/db08-0391
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    Lymphocytes of Type 2 Diabetic Women Carry a High Load of Stable Chromosomal AberrationsA Novel Risk Factor for Disease-Related Early Death
    Bernhard O. Boehm, Peter Möller, Josef Högel, Bernhard R. Winkelmann, Wilfried Renner, Silke Rosinger, Ursula Seelhorst, Britta Wellnitz, Winfried März, Julia Melzner and Silke Brüderlein
    Diabetes 2008 Nov; 57 (11): 2950-2957. https://doi.org/10.2337/db08-0274
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    Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice
    Nobuharu Fujii, Richard C. Ho, Yasuko Manabe, Niels Jessen, Taro Toyoda, William L. Holland, Scott A. Summers, Michael F. Hirshman and Laurie J. Goodyear
    Diabetes 2008 Nov; 57 (11): 2958-2966. https://doi.org/10.2337/db07-1187
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Signal Transduction

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    Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
    Takafumi Senokuchi, Chien-Ping Liang, Tracie A. Seimon, Seongah Han, Michihiro Matsumoto, Alexander S. Banks, Ji-Hye Paik, Ronald A. DePinho, Domenico Accili, Ira Tabas and Alan R. Tall
    Diabetes 2008 Nov; 57 (11): 2967-2976. https://doi.org/10.2337/db08-0520
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Obesity Studies

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    Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats
    Ruben Nogueiras, Christelle Veyrat-Durebex, Paula M. Suchanek, Marcella Klein, Johannes Tschöp, Charles Caldwell, Stephen C. Woods, Gabor Wittmann, Masahiko Watanabe, Zsolt Liposits, Csaba Fekete, Ofer Reizes, Francoise Rohner-Jeanrenaud and Matthias H. Tschöp
    Diabetes 2008 Nov; 57 (11): 2977-2991. https://doi.org/10.2337/db08-0161
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    Oxidative Stress Regulates Adipocyte Apolipoprotein E and Suppresses Its Expression in Obesity
    Doris Joy Espiritu and Theodore Mazzone
    Diabetes 2008 Nov; 57 (11): 2992-2998. https://doi.org/10.2337/db08-0592
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    Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease
    Hong Lan, Lizbeth M. Hoos, Li Liu, Glen Tetzloff, Weiwen Hu, Susan J. Abbondanzo, Galya Vassileva, Eric L. Gustafson, Joseph A. Hedrick and Harry R. Davis
    Diabetes 2008 Nov; 57 (11): 2999-3006. https://doi.org/10.2337/db08-0596
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    Persistence of Pre-Diabetes in Overweight and Obese Hispanic ChildrenAssociation With Progressive Insulin Resistance, Poor β-Cell Function, and Increasing Visceral Fat
    Michael I. Goran, Christianne Lane, Claudia Toledo-Corral and Marc J. Weigensberg
    Diabetes 2008 Nov; 57 (11): 3007-3012. https://doi.org/10.2337/db08-0445
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Immunology and Transplantation

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    Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes
    Paolo Fiorina, Andrea Vergani, Shirine Dada, Mollie Jurewicz, Masie Wong, Kenneth Law, Erxi Wu, Ze Tian, Reza Abdi, Indira Guleria, Scott Rodig, Kyri Dunussi-Joannopoulos, Jeffrey Bluestone and Mohamed H. Sayegh
    Diabetes 2008 Nov; 57 (11): 3013-3024. https://doi.org/10.2337/db08-0420
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    Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes
    Andrea P. Martin, Sara Rankin, Simon Pitchford, Israel F. Charo, Glaucia C. Furtado and Sergio A. Lira
    Diabetes 2008 Nov; 57 (11): 3025-3033. https://doi.org/10.2337/db08-0625
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Islet Studies

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    Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
    Mia C. Åkerfeldt, Jennifer Howes, Jeng Yie Chan, Veronica A. Stevens, Nacer Boubenna, Helen M. McGuire, Cecile King, Trevor J. Biden and D. Ross Laybutt
    Diabetes 2008 Nov; 57 (11): 3034-3044. https://doi.org/10.2337/db07-1802
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    Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
    Lucy Marzban, Alejandra Tomas, Thomas C. Becker, Lawrence Rosenberg, Jose Oberholzer, Paul E. Fraser, Philippe A. Halban and C. Bruce Verchere
    Diabetes 2008 Nov; 57 (11): 3045-3055. https://doi.org/10.2337/db08-0485
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    Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
    Irene Cozar-Castellano, George Harb, Karen Selk, Karen Takane, Rupangi Vasavada, Brian Sicari, Brian Law, Pili Zhang, Donald K. Scott, Nathalie Fiaschi-Taesch and Andrew F. Stewart
    Diabetes 2008 Nov; 57 (11): 3056-3068. https://doi.org/10.2337/db08-0393
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    β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1
    Amanda Ackermann Misfeldt, Robert H. Costa and Maureen Gannon
    Diabetes 2008 Nov; 57 (11): 3069-3077. https://doi.org/10.2337/db08-0878
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Pathophysiology

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    Plasma YKL-40A BMI-Independent Marker of Type 2 Diabetes
    Anders R. Nielsen, Christian Erikstrup, Julia S. Johansen, Christian P. Fischer, Peter Plomgaard, Rikke Krogh-Madsen, Sarah Taudorf, Birgitte Lindegaard and Bente K. Pedersen
    Diabetes 2008 Nov; 57 (11): 3078-3082. https://doi.org/10.2337/db08-0182
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Complications

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    Diffusion Tensor Imaging Identifies Deficits in White Matter Microstructure in Subjects With Type 1 Diabetes That Correlate With Reduced Neurocognitive Function
    Christopher T. Kodl, Daniel T. Franc, Jyothi P. Rao, Fiona S. Anderson, William Thomas, Bryon A. Mueller, Kelvin O. Lim and Elizabeth R. Seaquist
    Diabetes 2008 Nov; 57 (11): 3083-3089. https://doi.org/10.2337/db08-0724
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    High Glucose Induces Toll-Like Receptor Expression in Human MonocytesMechanism of Activation
    Mohan R. Dasu, Sridevi Devaraj, Ling Zhao, Daniel H. Hwang and Ishwarlal Jialal
    Diabetes 2008 Nov; 57 (11): 3090-3098. https://doi.org/10.2337/db08-0564
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    Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats
    Taiga Shibata, Keiko Naruse, Hideki Kamiya, Mika Kozakae, Masaki Kondo, Yutaka Yasuda, Nobuhisa Nakamura, Kimiko Ota, Takahiro Tosaki, Takashi Matsuki, Eitaro Nakashima, Yoji Hamada, Yutaka Oiso and Jiro Nakamura
    Diabetes 2008 Nov; 57 (11): 3099-3107. https://doi.org/10.2337/db08-0031
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    Association of Organochlorine Pesticides with Peripheral Neuropathy in Patients with Diabetes or Impaired Fasting Glucose
    Duk-Hee Lee, David R. Jacobs and Michael Steffes
    Diabetes 2008 Nov; 57 (11): 3108-3111. https://doi.org/10.2337/db08-0668
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Genetics

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    Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
    Marju Orho-Melander, Olle Melander, Candace Guiducci, Pablo Perez-Martinez, Dolores Corella, Charlotta Roos, Ryan Tewhey, Mark J. Rieder, Jennifer Hall, Goncalo Abecasis, E. Shyong Tai, Cullan Welch, Donna K. Arnett, Valeriya Lyssenko, Eero Lindholm, Richa Saxena, Paul I.W. de Bakker, Noel Burtt, Benjamin F. Voight, Joel N. Hirschhorn, Katherine L. Tucker, Thomas Hedner, Tiinamaija Tuomi, Bo Isomaa, Karl-Fredrik Eriksson, Marja-Riitta Taskinen, Björn Wahlstrand, Thomas E. Hughes, Laurence D. Parnell, Chao-Qiang Lai, Göran Berglund, Leena Peltonen, Erkki Vartiainen, Pekka Jousilahti, Aki S. Havulinna, Veikko Salomaa, Peter Nilsson, Leif Groop, David Altshuler, Jose M. Ordovas and Sekar Kathiresan
    Diabetes 2008 Nov; 57 (11): 3112-3121. https://doi.org/10.2337/db08-0516
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    Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association StudiesA Population-Based Study
    Mandy van Hoek, Abbas Dehghan, Jacqueline C.M. Witteman, Cornelia M. van Duijn, André G. Uitterlinden, Ben A. Oostra, Albert Hofman, Eric J.G. Sijbrands and A. Cecile J.W. Janssens
    Diabetes 2008 Nov; 57 (11): 3122-3128. https://doi.org/10.2337/db08-0425
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    Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk
    Hana Lango, Colin N.A. Palmer, Andrew D. Morris, Eleftheria Zeggini, Andrew T. Hattersley, Mark I. McCarthy, Timothy M. Frayling and Michael N. Weedon
    Diabetes 2008 Nov; 57 (11): 3129-3135. https://doi.org/10.2337/db08-0504
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    Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
    Kyle J. Gaulton, Cristen J. Willer, Yun Li, Laura J. Scott, Karen N. Conneely, Anne U. Jackson, William L. Duren, Peter S. Chines, Narisu Narisu, Lori L. Bonnycastle, Jingchun Luo, Maurine Tong, Andrew G. Sprau, Elizabeth W. Pugh, Kimberly F. Doheny, Timo T. Valle, Gonçalo R. Abecasis, Jaakko Tuomilehto, Richard N. Bergman, Francis S. Collins, Michael Boehnke and Karen L. Mohlke
    Diabetes 2008 Nov; 57 (11): 3136-3144. https://doi.org/10.2337/db07-1731
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    Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With ObesityLongitudinal Analyses in Two Cohort Studies and Functional Test
    Lu Qi, Kihwa Kang, Cuilin Zhang, Rob M. van Dam, Peter Kraft, David Hunter, Chih-Hao Lee and Frank B. Hu
    Diabetes 2008 Nov; 57 (11): 3145-3151. https://doi.org/10.2337/db08-0006
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    Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA GenotypePotential for Rapid Screening
    Jennifer M. Barker, Taylor M. Triolo, Theresa A. Aly, Erin E. Baschal, Sunanda R. Babu, Adam Kretowski, Marian J. Rewers and George S. Eisenbarth
    Diabetes 2008 Nov; 57 (11): 3152-3155. https://doi.org/10.2337/db08-0605
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    PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians
    Lijun Ma, Robert L. Hanson, Lorem N. Que, Yan Guo, Sayuko Kobes, Clifton Bogardus and Leslie J. Baier
    Diabetes 2008 Nov; 57 (11): 3156-3160. https://doi.org/10.2337/db07-1800
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    Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter VariantsA Lesson for Replication Studies
    Inês Barroso, Jian’an Luan, Eleanor Wheeler, Pamela Whittaker, Jon Wasson, Eleftheria Zeggini, Michael N. Weedon, Sarah Hunt, Ranganath Venkatesh, Timothy M. Frayling, Marcos Delgado, Rosalind J. Neuman, Jinghua Zhao, Richard Sherva, Benjamin Glaser, Mark Walker, Graham Hitman, Mark I. McCarthy, Andrew T. Hattersley, M. Alan Permutt, Nicholas J. Wareham and Panagiotis Deloukas
    Diabetes 2008 Nov; 57 (11): 3161-3165. https://doi.org/10.2337/db08-0719
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Erratum

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    Erratum
    Diabetes 2008 Nov; 57 (11): 3166. https://doi.org/10.2337/db08-er11
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Online Letters to the Editor

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    Comment on: Hosogai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation. Diabetes 56:901–911, 2007
    Maria Rita Negrão, Rosário Monteiro, Conceição Calhau, Raquel Soares and Isabel Azevedo
    Diabetes 2008 Nov; 57 (11): e15. https://doi.org/10.2337/db08-0603
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November 2008, 57(11)
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  • Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
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  • The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion
  • A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels
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