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Table of Contents

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April 01 2008; volume 57 issue 4

Commentaries

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    Thioredoxin-Interacting Protein Is Killing My β-cells!
    John A. Corbett
    Diabetes 2008 Apr; 57 (4): 797-798. https://doi.org/10.2337/db08-0055
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    Insulin Mutations in DiabetesThe Clinical Spectrum
    Benjamin Glaser
    Diabetes 2008 Apr; 57 (4): 799-800. https://doi.org/10.2337/db08-0116
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Metabolism

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    Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary SyndromeEx Vivo and In Vivo Regulation of Omentin-1 by Insulin and Glucose
    Bee K. Tan, Raghu Adya, S. Farhatullah, Kris C. Lewandowski, Paul O’Hare, Hendrik Lehnert and Harpal S. Randeva
    Diabetes 2008 Apr; 57 (4): 801-808. https://doi.org/10.2337/db07-0990
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    PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases The Boston Puerto Rican Health Study
    Chao-Qiang Lai, Katherine L. Tucker, Laurence D. Parnell, Xian Adiconis, Bibiana García-Bailo, John Griffith, Mohsen Meydani and José M. Ordovás
    Diabetes 2008 Apr; 57 (4): 809-816. https://doi.org/10.2337/db07-1238
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    Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro
    Yin Li, Changtao Jiang, Guoheng Xu, Nanping Wang, Yi Zhu, Chaoshu Tang and Xian Wang
    Diabetes 2008 Apr; 57 (4): 817-827. https://doi.org/10.2337/db07-0617
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    Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal
    Jenny D. Chiu, Joyce M. Richey, L. Nicole Harrison, Edward Zuniga, Cathryn M. Kolka, Erlinda Kirkman, Martin Ellmerer and Richard N. Bergman
    Diabetes 2008 Apr; 57 (4): 828-835. https://doi.org/10.2337/db07-1444
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    Activation of Central Lactate Metabolism Lowers Glucose Production in Uncontrolled Diabetes and Diet-Induced Insulin Resistance
    Madhu Chari, Carol K.L. Lam, Penny Y.T. Wang and Tony K.T. Lam
    Diabetes 2008 Apr; 57 (4): 836-840. https://doi.org/10.2337/db07-1464
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    Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate
    Jose E. Galgani, Leonie K. Heilbronn, Koichiro Azuma, David E. Kelley, Jeanine B. Albu, Xavier Pi-Sunyer, Steven R. Smith, Eric Ravussin and , and the Look AHEAD Adipose Research Group
    Diabetes 2008 Apr; 57 (4): 841-845. https://doi.org/10.2337/db08-0043
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Signal Transduction

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    Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis
    Sara C. Martinez, Katsuya Tanabe, Corentin Cras-Méneur, Nada A. Abumrad, Ernesto Bernal-Mizrachi and M. Alan Permutt
    Diabetes 2008 Apr; 57 (4): 846-859. https://doi.org/10.2337/db07-0595
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    AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5
    Sean L. McGee, Bryce J.W. van Denderen, Kirsten F. Howlett, Janelle Mollica, Jonathan D. Schertzer, Bruce E. Kemp and Mark Hargreaves
    Diabetes 2008 Apr; 57 (4): 860-867. https://doi.org/10.2337/db07-0843
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    Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets
    Byung-Ju Kim, Kwang-Hyun Park, Chang-Yeol Yim, Shin Takasawa, Hiroshi Okamoto, Mie-Jae Im and Uh-Hyun Kim
    Diabetes 2008 Apr; 57 (4): 868-878. https://doi.org/10.2337/db07-0443
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    Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes
    Narkunarajaa Shanmugam, James L. Figarola, Yan Li, Piotr M. Swiderski, Samual Rahbar and Rama Natarajan
    Diabetes 2008 Apr; 57 (4): 879-888. https://doi.org/10.2337/db07-1204
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    Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes
    Tayyeba K. Ali, Suraporn Matragoon, Bindu A. Pillai, Gregory I. Liou and Azza B. El-Remessy
    Diabetes 2008 Apr; 57 (4): 889-898. https://doi.org/10.2337/db07-1669
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Obesity Studies

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    Physiological and Molecular Determinants of Insulin Action in the Baboon
    Alberto O. Chavez, Juan C. Lopez-Alvarenga, M. Elizabeth Tejero, Curtis Triplitt, Raul A. Bastarrachea, Apiradee Sriwijitkamol, Puntip Tantiwong, V. Saroja Voruganti, Nicolas Musi, Anthony G. Comuzzie, Ralph A. DeFronzo and Franco Folli
    Diabetes 2008 Apr; 57 (4): 899-908. https://doi.org/10.2337/db07-0790
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Immunology and Transplantation

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    B-Cells Promote Intra-Islet CD8+ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes
    Gillian M. Brodie, Maja Wallberg, Pere Santamaria, F. Susan Wong and E. Allison Green
    Diabetes 2008 Apr; 57 (4): 909-917. https://doi.org/10.2337/db07-1256
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    Targeting of Pancreatic Glia in Type 1 Diabetes
    Hubert Tsui, Yin Chan, Lan Tang, Shawn Winer, Roy K. Cheung, Geoffrey Paltser, Thirumahal Selvanantham, Alisha R. Elford, James R. Ellis, Dorothy J. Becker, Pamela S. Ohashi and Hans-Michael Dosch
    Diabetes 2008 Apr; 57 (4): 918-928. https://doi.org/10.2337/db07-0226
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    Association of IL-1ra and Adiponectin With C-Peptide and Remission in Patients With Type 1 Diabetes
    Christian Pfleger, Henrik B. Mortensen, Lars Hansen, Christian Herder, Bart O. Roep, Hillary Hoey, Henk-Jan Aanstoot, Mirjana Kocova, Nanette C. Schloot and , on behalf of the Hvidøre Study Group on Childhood Diabetes
    Diabetes 2008 Apr; 57 (4): 929-937. https://doi.org/10.2337/db07-1697
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Islet Studies

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    Thioredoxin-Interacting ProteinA Critical Link Between Glucose Toxicity and β-Cell Apoptosis
    Junqin Chen, Geetu Saxena, Imran N. Mungrue, Aldons J. Lusis and Anath Shalev
    Diabetes 2008 Apr; 57 (4): 938-944. https://doi.org/10.2337/db07-0715
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    mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
    Merav Fraenkel, Mali Ketzinel-Gilad, Yafa Ariav, Orit Pappo, Melis Karaca, Julien Castel, Marie-France Berthault, Christophe Magnan, Erol Cerasi, Nurit Kaiser and Gil Leibowitz
    Diabetes 2008 Apr; 57 (4): 945-957. https://doi.org/10.2337/db07-0922
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    Regulated β-Cell Regeneration in the Adult Mouse Pancreas
    David A. Cano, Ingrid C. Rulifson, Patrick W. Heiser, Lamorna B. Swigart, Stella Pelengaris, Mike German, Gerard I. Evan, Jeffrey A. Bluestone and Matthias Hebrok
    Diabetes 2008 Apr; 57 (4): 958-966. https://doi.org/10.2337/db07-0913
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    Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function
    Riccarda Granata, Fabio Settanni, Davide Gallo, Letizia Trovato, Luigi Biancone, Vincenzo Cantaluppi, Rita Nano, Marta Annunziata, Pietro Campiglia, Elisa Arnoletti, Corrado Ghè, Marco Volante, Mauro Papotti, Giampiero Muccioli and Ezio Ghigo
    Diabetes 2008 Apr; 57 (4): 967-979. https://doi.org/10.2337/db07-1104
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Pathophysiology

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    Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program
    Kieren J. Mather, Tohru Funahashi, Yuji Matsuzawa, Sharon Edelstein, George A. Bray, Steven E. Kahn, Jill Crandall, Santica Marcovina, Barry Goldstein, Ronald Goldberg and , for the Diabetes Prevention Program
    Diabetes 2008 Apr; 57 (4): 980-986. https://doi.org/10.2337/db07-1419
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    Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content
    Frederico G.S. Toledo, Elizabeth V. Menshikova, Koichiro Azuma, Zofia Radiková, Carol A. Kelley, Vladimir B. Ritov and David E. Kelley
    Diabetes 2008 Apr; 57 (4): 987-994. https://doi.org/10.2337/db07-1429
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Complications

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    Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited
    John M. Lachin, Saul Genuth, David M. Nathan, Bernard Zinman, Brandy N. Rutledge and , for the DCCT/EDIC Research Group
    Diabetes 2008 Apr; 57 (4): 995-1001. https://doi.org/10.2337/db07-1618
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    Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy
    Cory Toth, Ling Ling Rong, Christina Yang, Jose Martinez, Fei Song, Noor Ramji, Valentine Brussee, Wei Liu, Jeff Durand, Minh Dang Nguyen, Ann Marie Schmidt and Douglas W. Zochodne
    Diabetes 2008 Apr; 57 (4): 1002-1017. https://doi.org/10.2337/db07-0339
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    ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes
    Chris Tikellis, Katarzyna Bialkowski, Josepha Pete, Karen Sheehy, Qui Su, Colin Johnston, Mark E. Cooper and Merlin C. Thomas
    Diabetes 2008 Apr; 57 (4): 1018-1025. https://doi.org/10.2337/db07-1212
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Original Articles

  • Pharmacology and Therapeutics

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      Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier Through Differential Regulation of VEGF-A and Its Receptors in Early Diabetic Rat Retinas
      Xinyuan Zhang, Shisan Bao, Donna Lai, Robert W. Rapkins and Mark C. Gillies
      Diabetes 2008 Apr; 57 (4): 1026-1033. https://doi.org/10.2337/db07-0982
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Genetics

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    Insulin Mutation Screening in 1,044 Patients With DiabetesMutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood
    Emma L. Edghill, Sarah E. Flanagan, Ann-Marie Patch, Chris Boustred, Andrew Parrish, Beverley Shields, Maggie H. Shepherd, Khalid Hussain, Ritika R. Kapoor, Maciej Malecki, Michael J. MacDonald, Julie Støy, Donald F. Steiner, Louis H. Philipson, Graeme I. Bell, the Neonatal Diabetes International Collaborative Group, Andrew T. Hattersley and Sian Ellard
    Diabetes 2008 Apr; 57 (4): 1034-1042. https://doi.org/10.2337/db07-1405
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    A Polymorphism in the Zinc Transporter Gene SLC30A8 Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients
    Eun Seok Kang, Myoung Soo Kim, Yu Seun Kim, Chul Hoon Kim, Seung Jin Han, Sung Wan Chun, Kyu Yeon Hur, Chung Mo Nam, Chul Woo Ahn, Bong Soo Cha, Soon Il Kim and Hyun Chul Lee
    Diabetes 2008 Apr; 57 (4): 1043-1047. https://doi.org/10.2337/db07-0761
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    Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans
    Mary Helen Black, Tasha E. Fingerlin, Hooman Allayee, Weiming Zhang, Anny H. Xiang, Enrique Trigo, Jaana Hartiala, Allison B. Lehtinen, Steven M. Haffner, Richard N. Bergman, Richard C. McEachin, Siri L. Kjos, Jean M. Lawrence, Thomas A. Buchanan and Richard M. Watanabe
    Diabetes 2008 Apr; 57 (4): 1048-1056. https://doi.org/10.2337/db07-0848
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    Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy
    Keith L. Keene, Josyf C. Mychaleckyj, Shelly G. Smith, Tennille S. Leak, Peter S. Perlegas, Carl D. Langefeld, Barry I. Freedman, Stephen S. Rich, Donald W. Bowden and Michèle M. Sale
    Diabetes 2008 Apr; 57 (4): 1057-1062. https://doi.org/10.2337/db07-0886
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    The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men
    Nadir Cheurfa, Danièle Dubois-Laforgue, Daniela A.F. Ferrarezi, André F. Reis, Guilherme M. Brenner, Clara Bouché, Claude Le Feuvre, Frédéric Fumeron, José Timsit, Michel Marre and Gilberto Velho
    Diabetes 2008 Apr; 57 (4): 1063-1068. https://doi.org/10.2337/db07-1292
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    HNF4α and the Ca-Channel TRPC1 Are Novel Disease Candidate Genes in Diabetic Nephropathy
    Monika Niehof and Jürgen Borlak
    Diabetes 2008 Apr; 57 (4): 1069-1077. https://doi.org/10.2337/db07-1065
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    Variations of the Perforin Gene in Patients With Type 1 Diabetes
    Elisabetta Orilieri, Giuseppe Cappellano, Rita Clementi, Angela Cometa, Massimo Ferretti, Elisa Cerutti, Francesco Cadario, Miryam Martinetti, Daniela Larizza, Valeria Calcaterra, Giuseppe D’Annunzio, Renata Lorini, Franco Cerutti, Graziella Bruno, Annalisa Chiocchetti and Umberto Dianzani
    Diabetes 2008 Apr; 57 (4): 1078-1083. https://doi.org/10.2337/db07-0947
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    HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes RiskAnalysis of the Type 1 Diabetes Genetics Consortium Families
    Henry Erlich, Ana Maria Valdes, Janelle Noble, Joyce A. Carlson, Mike Varney, Pat Concannon, Josyf C. Mychaleckyj, John A. Todd, Persia Bonella, Anna Lisa Fear, Eva Lavant, Anthony Louey, Priscilla Moonsamy and , for the Type 1 Diabetes Genetics Consortium
    Diabetes 2008 Apr; 57 (4): 1084-1092. https://doi.org/10.2337/db07-1331
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    Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D. Palmer, Mark O. Goodarzi, Carl D. Langefeld, Julie Ziegler, Jill M. Norris, Steven M. Haffner, Michael Bryer-Ash, Richard N. Bergman, Lynne E. Wagenknecht, Kent D. Taylor, Jerome I. Rotter and Donald W. Bowden
    Diabetes 2008 Apr; 57 (4): 1093-1100. https://doi.org/10.2337/db07-1169
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    Genetic Variants in the UCP2-UCP3 Gene Cluster and Risk of Diabetes in the Women's Health Initiative Observational Study
    Yi-Hsiang Hsu, Tianhua Niu, Yiqing Song, Lesley Tinker, Lewis H. Kuller and Simin Liu
    Diabetes 2008 Apr; 57 (4): 1101-1107. https://doi.org/10.2337/db07-1269
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    Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study
    Allison B. Lehtinen, Christopher Newton-Cheh, Julie T. Ziegler, Carl D. Langefeld, Barry I. Freedman, Kurt R. Daniel, David M. Herrington and Donald W. Bowden
    Diabetes 2008 Apr; 57 (4): 1108-1114. https://doi.org/10.2337/db07-1365
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    Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early InfancyA Report From the French ND (Neonatal Diabetes) Study Group
    Michel Polak, Aurélie Dechaume, Hélène Cavé, Revital Nimri, Hélène Crosnier, Véronique Sulmont, Marc de Kerdanet, Raphael Scharfmann, Yael Lebenthal, Philippe Froguel and Martine Vaxillaire
    Diabetes 2008 Apr; 57 (4): 1115-1119. https://doi.org/10.2337/db07-1358
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    Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort
    Mario Falchi, Scott G. Wilson, Dimitrios Paximadas, Ramasamyiyer Swaminathan and Tim D. Spector
    Diabetes 2008 Apr; 57 (4): 1120-1124. https://doi.org/10.2337/db07-0708
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    The ENPP1 K121Q Polymorphism Is Associated With Type 2 Diabetes in European PopulationsEvidence From an Updated Meta-Analysis in 42,042 Subjects
    Jarred B. McAteer, Sabrina Prudente, Simonetta Bacci, Helen N. Lyon, Joel N. Hirschhorn, Vincenzo Trischitta, Jose C. Florez and , for the ENPP1 Consortium
    Diabetes 2008 Apr; 57 (4): 1125-1130. https://doi.org/10.2337/db07-1336
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    Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes
    Anders Molven, Monika Ringdal, Anita M. Nordbø, Helge Ræder, Julie Støy, Gregory M. Lipkind, Donald F. Steiner, Louis H. Philipson, Ines Bergmann, Dagfinn Aarskog, Dag E. Undlien, Geir Joner, Oddmund Søvik, , the Norwegian Childhood Diabetes Study Group, Graeme I. Bell and Pål R. Njølstad
    Diabetes 2008 Apr; 57 (4): 1131-1135. https://doi.org/10.2337/db07-1467
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    Association of Variants in the Sterol Regulatory Element-Binding Factor 1 (SREBF1) Gene With Type 2 Diabetes, Glycemia, and Insulin ResistanceA Study of 15,734 Danish Subjects
    Niels Grarup, Kirstine L. Stender-Petersen, Ehm A. Andersson, Torben Jørgensen, Knut Borch-Johnsen, Annelli Sandbæk, Torsten Lauritzen, Ole Schmitz, Torben Hansen and Oluf Pedersen
    Diabetes 2008 Apr; 57 (4): 1136-1142. https://doi.org/10.2337/db07-1534
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    A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study
    Hakon Hakonarson, Hui-Qi Qu, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph T. Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton, Andrew W. Eckert, Kiran Annaiah, Margaret L. Lawson, F. George Otieno, Erin Santa, Julie L. Shaner, Ryan M. Smith, Chioma C. Onyiah, Robert Skraban, Rosetta M. Chiavacci, Luke J. Robinson, Charles A. Stanley, Susan E. Kirsch, Marcella Devoto, Dimitri S. Monos, Struan F.A. Grant and Constantin Polychronakos
    Diabetes 2008 Apr; 57 (4): 1143-1146. https://doi.org/10.2337/db07-1305
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    Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study
    Ron Do, Swneke D. Bailey, Katia Desbiens, Alexandre Belisle, Alexandre Montpetit, Claude Bouchard, Louis Pérusse, Marie-Claude Vohl and James C. Engert
    Diabetes 2008 Apr; 57 (4): 1147-1150. https://doi.org/10.2337/db07-1267
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April 2008, 57(4)
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  • Commentaries
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  • Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
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  • Poverty and Obesity in the U.S.
  • The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion
  • A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels
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