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Genetics

A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

  1. Hakon Hakonarson1,2,
  2. Hui-Qi Qu3,
  3. Jonathan P. Bradfield1,
  4. Luc Marchand3,
  5. Cecilia E. Kim1,
  6. Joseph T. Glessner1,
  7. Rosemarie Grabs3,
  8. Tracy Casalunovo1,
  9. Shayne P. Taback4,
  10. Edward C. Frackelton1,
  11. Andrew W. Eckert1,
  12. Kiran Annaiah1,
  13. Margaret L. Lawson5,
  14. F. George Otieno1,
  15. Erin Santa1,
  16. Julie L. Shaner1,
  17. Ryan M. Smith1,
  18. Chioma C. Onyiah1,
  19. Robert Skraban1,
  20. Rosetta M. Chiavacci1,
  21. Luke J. Robinson1,
  22. Charles A. Stanley6,
  23. Susan E. Kirsch7,
  24. Marcella Devoto2,8,
  25. Dimitri S. Monos9,10,
  26. Struan F.A. Grant1,2 and
  27. Constantin Polychronakos3
  1. 1Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  2. 2Department of Pediatrics and Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  3. 3Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
  4. 4Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
  5. 5Division of Endocrinology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
  6. 6Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  7. 7Markham-Stouffville Hospital, Markham, Ontario, Canada
  8. 8Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
  9. 9Department of Pathology and Laboratory Medicine, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  10. 10Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  1. Address correspondence and reprint requests to Hakon Hakonarson, MD, PhD, Director, Center for Applied Genomics, 1216E Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104-4318, E-mail: hakonarson{at}chop.edu; or to Constantin Polychronakos, MD, FRCPC, McGill University Health Center (Children's Hospital), 2300 Tupper, Montréal, QC, Canada, H3H 1P3, E-mail: constantin.polychronakos{at}mcgill.ca
Diabetes 2008 Apr; 57(4): 1143-1146. https://doi.org/10.2337/db07-1305
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Article Information

vol. 57 no. 4 1143-1146
DOI 
https://doi.org/10.2337/db07-1305
PubMed 
18198356

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received September 13, 2007
  • Accepted January 10, 2008
  • Published in print March 27, 2008.
  • Published online ahead of print January 15, 2008.

Article Versions

  • Previous version (January 15, 2008 - 13:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
DIABETES

Author Information

  1. Hakon Hakonarson1,2,
  2. Hui-Qi Qu3,
  3. Jonathan P. Bradfield1,
  4. Luc Marchand3,
  5. Cecilia E. Kim1,
  6. Joseph T. Glessner1,
  7. Rosemarie Grabs3,
  8. Tracy Casalunovo1,
  9. Shayne P. Taback4,
  10. Edward C. Frackelton1,
  11. Andrew W. Eckert1,
  12. Kiran Annaiah1,
  13. Margaret L. Lawson5,
  14. F. George Otieno1,
  15. Erin Santa1,
  16. Julie L. Shaner1,
  17. Ryan M. Smith1,
  18. Chioma C. Onyiah1,
  19. Robert Skraban1,
  20. Rosetta M. Chiavacci1,
  21. Luke J. Robinson1,
  22. Charles A. Stanley6,
  23. Susan E. Kirsch7,
  24. Marcella Devoto2,8,
  25. Dimitri S. Monos9,10,
  26. Struan F.A. Grant1,2 and
  27. Constantin Polychronakos3
  1. 1Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  2. 2Department of Pediatrics and Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  3. 3Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
  4. 4Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
  5. 5Division of Endocrinology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
  6. 6Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  7. 7Markham-Stouffville Hospital, Markham, Ontario, Canada
  8. 8Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
  9. 9Department of Pathology and Laboratory Medicine, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  10. 10Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
  1. Address correspondence and reprint requests to Hakon Hakonarson, MD, PhD, Director, Center for Applied Genomics, 1216E Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104-4318, E-mail: hakonarson{at}chop.edu; or to Constantin Polychronakos, MD, FRCPC, McGill University Health Center (Children's Hospital), 2300 Tupper, Montréal, QC, Canada, H3H 1P3, E-mail: constantin.polychronakos{at}mcgill.ca
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A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study
Hakon Hakonarson, Hui-Qi Qu, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph T. Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton, Andrew W. Eckert, Kiran Annaiah, Margaret L. Lawson, F. George Otieno, Erin Santa, Julie L. Shaner, Ryan M. Smith, Chioma C. Onyiah, Robert Skraban, Rosetta M. Chiavacci, Luke J. Robinson, Charles A. Stanley, Susan E. Kirsch, Marcella Devoto, Dimitri S. Monos, Struan F.A. Grant, Constantin Polychronakos
Diabetes Apr 2008, 57 (4) 1143-1146; DOI: 10.2337/db07-1305

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A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study
Hakon Hakonarson, Hui-Qi Qu, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph T. Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton, Andrew W. Eckert, Kiran Annaiah, Margaret L. Lawson, F. George Otieno, Erin Santa, Julie L. Shaner, Ryan M. Smith, Chioma C. Onyiah, Robert Skraban, Rosetta M. Chiavacci, Luke J. Robinson, Charles A. Stanley, Susan E. Kirsch, Marcella Devoto, Dimitri S. Monos, Struan F.A. Grant, Constantin Polychronakos
Diabetes Apr 2008, 57 (4) 1143-1146; DOI: 10.2337/db07-1305
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Keywords

GWA, genome-wide association
LD, linkage disequilibrium
SNP, single nucleotide polymorphism
WTCCC, Wellcome Trust Case-Control Consortium

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