Diabetes: 57 (5)

May 01 2008; volume 57 issue 5

Commentaries

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Abdominal Adiposity and Diabetes RiskThe Importance of Precise Measures and Longitudinal Studies
Anthony J.G. Hanley and Lynne E. Wagenknecht

Diabetes 2008 May; 57 (5): 1153-1155. https://doi.org/10.2337/db08-0286

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Islet Autoreactive CD8 T-cells in Type 1 DiabetesLicensed to Kill?
Bart O. Roep

Diabetes 2008 May; 57 (5): 1156. https://doi.org/10.2337/db08-0264

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Central Versus Peripheral Glucose Sensing and the Response to Hypoglycemia
Alan D. Cherrington

Diabetes 2008 May; 57 (5): 1158-1159. https://doi.org/10.2337/db08-0315

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Genetic Similarities Between Latent Autoimmune Diabetes and Type 1 and Type 2 Diabetes
Andrea K. Steck and George S. Eisenbarth

Diabetes 2008 May; 57 (5): 1160-1162. https://doi.org/10.2337/db07-1786

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Editorial

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Intensive Glycemic Control and Cardiovascular Disease Observations From the ACCORD StudyNow What Can a Clinician Possibly Think?
William T. Cefalu and Karol Watson

Diabetes 2008 May; 57 (5): 1163-1165. https://doi.org/10.2337/db08-0220

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Metabolism

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Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance
K. Sreekumaran Nair, Maureen L. Bigelow, Yan W. Asmann, Lisa S. Chow, Jill M. Coenen-Schimke, Katherine A. Klaus, Zeng-Kui Guo, Raghavakaimal Sreekumar and Brian A. Irving

Diabetes 2008 May; 57 (5): 1166-1175. https://doi.org/10.2337/db07-1556

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Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism
Christopher R. Cederroth, Manlio Vinciguerra, Asllan Gjinovci, Françoise Kühne, Marcella Klein, Manon Cederroth, Dorothée Caille, Mariane Suter, Dietbert Neumann, Richard W. James, Daniel R. Doerge, Theo Wallimann, Paolo Meda, Michelangelo Foti, Françoise Rohner-Jeanrenaud, Jean-Dominique Vassalli and Serge Nef

Diabetes 2008 May; 57 (5): 1176-1185. https://doi.org/10.2337/db07-0630

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Plasma Free Fatty Acid Storage in Subcutaneous and Visceral Adipose Tissue in Postabsorptive Women
Christina Koutsari, Daniel A. Dumesic, Bruce W. Patterson, Susanne B. Votruba and Michael D. Jensen

Diabetes 2008 May; 57 (5): 1186-1194. https://doi.org/10.2337/db07-0664

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Signal Transduction

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Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells
Karim Bouzakri, Pascale Ribaux, Alejandra Tomas, Geraldine Parnaud, Katharina Rickenbach and Philippe A. Halban

Diabetes 2008 May; 57 (5): 1195-1204. https://doi.org/10.2337/db07-1469

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Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH₂-Terminal Kinase Pathway
Mourad Ferdaoussi, Saida Abdelli, Jiang-Yan Yang, Marion Cornu, Guy Niederhauser, Dimitri Favre, Christian Widmann, Romano Regazzi, Bernard Thorens, Gérard Waeber and Amar Abderrahmani

Diabetes 2008 May; 57 (5): 1205-1215. https://doi.org/10.2337/db07-1214

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FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes
Damien Demozay, Jean-Christophe Mas, Stephane Rocchi and Emmanuel Van Obberghen

Diabetes 2008 May; 57 (5): 1216-1226. https://doi.org/10.2337/db07-0389

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STAT3 Sensitizes Insulin Signaling by Negatively Regulating Glycogen Synthase Kinase-3β
Akira Moh, Wenjun Zhang, Sidney Yu, Jun Wang, Xuming Xu, Jiliang Li and Xin-Yuan Fu

Diabetes 2008 May; 57 (5): 1227-1235. https://doi.org/10.2337/db06-1582

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Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways
Zeynep Dogusan, Mónica García, Daisy Flamez, Lena Alexopoulou, Michel Goldman, Conny Gysemans, Chantal Mathieu, Claude Libert, Decio L. Eizirik and Joanne Rasschaert

Diabetes 2008 May; 57 (5): 1236-1245. https://doi.org/10.2337/db07-0844

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Obesity Studies

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Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans
Xinmei Zhang, Dennis C.Y. Yeung, Michal Karpisek, David Stejskal, Zhi-Guang Zhou, Feng Liu, Rachel L.C. Wong, Wing-Sun Chow, Annette W.K. Tso, Karen S.L. Lam and Aimin Xu

Diabetes 2008 May; 57 (5): 1246-1253. https://doi.org/10.2337/db07-1476

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Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue
Elizabeth A. Kirk, Zachary K. Sagawa, Thomas O. McDonald, Kevin D. O'Brien and Jay W. Heinecke

Diabetes 2008 May; 57 (5): 1254-1261. https://doi.org/10.2337/db07-1061

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The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids
Tara M. D'Eon, Kerry A. Pierce, Jeffery J. Roix, Andrew Tyler, Hong Chen and Sandra R. Teixeira

Diabetes 2008 May; 57 (5): 1262-1268. https://doi.org/10.2337/db07-1186

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Visceral Adiposity, Not Abdominal Subcutaneous Fat Area, Is Associated With an Increase in Future Insulin Resistance in Japanese Americans
Tomoshige Hayashi, Edward J. Boyko, Marguerite J. McNeely, Donna L. Leonetti, Steven E. Kahn and Wilfred Y. Fujimoto

Diabetes 2008 May; 57 (5): 1269-1275. https://doi.org/10.2337/db07-1378

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Immunology and Transplantation

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Identification of Tyrosine Phosphatase 2_(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic PatientsThe Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2
Claudio Tiberti, Carla Giordano, Mattia Locatelli, Emanuele Bosi, Gian Franco Bottazzo, Raffaella Buzzetti, Domenico Cucinotta, Aldo Galluzzo, Alberto Falorni and Francesco Dotta

Diabetes 2008 May; 57 (5): 1276-1283. https://doi.org/10.2337/db07-0874

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Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells
Mark D. McKenzie, Emma M. Carrington, Thomas Kaufmann, Andreas Strasser, David C.S. Huang, Thomas W.H. Kay, Janette Allison and Helen E. Thomas

Diabetes 2008 May; 57 (5): 1284-1292. https://doi.org/10.2337/db07-1692

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COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity
Gustavo Fenalti, Christiane S. Hampe, Yasir Arafat, Ruby H.P. Law, J. Paul Banga, Ian R. Mackay, James C. Whisstock, Ashley M. Buckle and Merrill J. Rowley

Diabetes 2008 May; 57 (5): 1293-1301. https://doi.org/10.2337/db07-1461

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Regulatory T-Cells Protect From Type 1 Diabetes After Induction by Coxsackievirus Infection in the Context of Transforming Growth Factor-β
Martin J. Richer, Nadine Straka, Dianne Fang, Iryna Shanina and Marc S. Horwitz

Diabetes 2008 May; 57 (5): 1302-1311. https://doi.org/10.2337/db07-1460

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The Frequency and Immunodominance of Islet-Specific CD8⁺ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment
Emanuela Martinuzzi, Giulia Novelli, Matthieu Scotto, Philippe Blancou, Jean-Marie Bach, Lucy Chaillous, Graziella Bruno, Lucienne Chatenoud, Peter van Endert and Roberto Mallone

Diabetes 2008 May; 57 (5): 1312-1320. https://doi.org/10.2337/db07-1594

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On the Pathogenicity of Autoantigen-Specific T-Cell Receptors
Amanda R. Burton, Erica Vincent, Paula Y. Arnold, Greig P. Lennon, Matthew Smeltzer, Chin-Shang Li, Kathryn Haskins, John Hutton, Roland M. Tisch, Eli E. Sercarz, Pere Santamaria, Creg J. Workman and Dario A.A. Vignali

Diabetes 2008 May; 57 (5): 1321-1330. https://doi.org/10.2337/db07-1129

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Inhibition of Dipeptidyl Peptidase IV With Sitagliptin (MK0431) Prolongs Islet Graft Survival in Streptozotocin-Induced Diabetic Mice
Su-Jin Kim, Cuilan Nian, Doris J. Doudet and Christopher H.S. McIntosh

Diabetes 2008 May; 57 (5): 1331-1339. https://doi.org/10.2337/db07-1639

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Pathophysiology

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Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients
Elza Muscelli, Andrea Mari, Arturo Casolaro, Stefania Camastra, Giuseppe Seghieri, Amalia Gastaldelli, Jens J. Holst and Ele Ferrannini

Diabetes 2008 May; 57 (5): 1340-1348. https://doi.org/10.2337/db07-1315

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Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients
Antonio Ceriello, Katherine Esposito, Ludovica Piconi, Michael A. Ihnat, Jessica E. Thorpe, Roberto Testa, Massimo Boemi and Dario Giugliano

Diabetes 2008 May; 57 (5): 1349-1354. https://doi.org/10.2337/db08-0063

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Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis
Luca Valenti, Raffaela Rametta, Paola Dongiovanni, Marco Maggioni, Anna Ludovica Fracanzani, Marco Zappa, Enzo Lattuada, Giancarlo Roviaro and Silvia Fargion

Diabetes 2008 May; 57 (5): 1355-1362. https://doi.org/10.2337/db07-0714

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Complications

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Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia
Owen Chan, Haiying Cheng, Raimund Herzog, Daniel Czyzyk, Wanling Zhu, Ajin Wang, Rory J. McCrimmon, Margretta R. Seashore and Robert S. Sherwin

Diabetes 2008 May; 57 (5): 1363-1370. https://doi.org/10.2337/db07-1559

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Ventromedial Hypothalamic Glucokinase Is an Important Mediator of the Counterregulatory Response to Insulin-Induced Hypoglycemia
Barry E. Levin, Thomas C. Becker, Jun-ichi Eiki, Bei B. Zhang and Ambrose A. Dunn-Meynell

Diabetes 2008 May; 57 (5): 1371-1379. https://doi.org/10.2337/db07-1755

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The Locus for Hypoglycemic Detection Shifts With the Rate of Fall in GlycemiaThe Role of Portal–Superior Mesenteric Vein Glucose Sensing
Maziyar Saberi, MaryAnn Bohland and Casey M. Donovan

Diabetes 2008 May; 57 (5): 1380-1386. https://doi.org/10.2337/db07-1528

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5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy
Rose A. Gubitosi-Klug, Ramaprasad Talahalli, Yunpeng Du, Jerry L. Nadler and Timothy S. Kern

Diabetes 2008 May; 57 (5): 1387-1393. https://doi.org/10.2337/db07-1217

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Pharmacology and Therapeutics

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Selective Activation of Peroxisome Proliferator–Activated Receptor (PPAR)α and PPARγ Induces Neoangiogenesis Through a Vascular Endothelial Growth Factor–Dependent Mechanism
Federico Biscetti, Eleonora Gaetani, Andrea Flex, Tamar Aprahamian, Teresa Hopkins, Giuseppe Straface, Giovanni Pecorini, Egidio Stigliano, Roy C. Smith, Flavia Angelini, John J. Castellot and Roberto Pola

Diabetes 2008 May; 57 (5): 1394-1404. https://doi.org/10.2337/db07-0765

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Liver-Specific Peroxisome Proliferator–Activated Receptor α Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan
Markus Clemenz, Nikolaj Frost, Michael Schupp, Sandrine Caron, Anna Foryst-Ludwig, Christian Böhm, Martin Hartge, Ronald Gust, Bart Staels, Thomas Unger and Ulrich Kintscher

Diabetes 2008 May; 57 (5): 1405-1413. https://doi.org/10.2337/db07-0839

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Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex IA Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
Nigel Turner, Jing-Ya Li, Alison Gosby, Sabrina W.C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Li-Hong Hu, Jia Li and Ji-Ming Ye

Diabetes 2008 May; 57 (5): 1414-1418. https://doi.org/10.2337/db07-1552

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Genetics

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Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
Rachel M. Freathy, Nicholas J. Timpson, Debbie A. Lawlor, Anneli Pouta, Yoav Ben-Shlomo, Aimo Ruokonen, Shah Ebrahim, Beverley Shields, Eleftheria Zeggini, Michael N. Weedon, Cecilia M. Lindgren, Hana Lango, David Melzer, Luigi Ferrucci, Giuseppe Paolisso, Matthew J. Neville, Fredrik Karpe, Colin N.A. Palmer, Andrew D. Morris, Paul Elliott, Marjo-Riitta Jarvelin, George Davey Smith, Mark I. McCarthy, Andrew T. Hattersley and Timothy M. Frayling

Diabetes 2008 May; 57 (5): 1419-1426. https://doi.org/10.2337/db07-1466

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AHSG Tag Single Nucleotide Polymorphisms Associate With Type 2 Diabetes and DyslipidemiaStudies of Metabolic Traits in 7,683 White Danish Subjects
Gitte Andersen, Kristoffer Sølvsten Burgdorf, Thomas Sparsø, Knut Borch-Johnsen, Torben Jørgensen, Torben Hansen and Oluf Pedersen

Diabetes 2008 May; 57 (5): 1427-1432. https://doi.org/10.2337/db07-0558

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Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes
Camilla Cervin, Valeriya Lyssenko, Ekaterine Bakhtadze, Eero Lindholm, Peter Nilsson, Tiinamaija Tuomi, Corrado M. Cilio and Leif Groop

Diabetes 2008 May; 57 (5): 1433-1437. https://doi.org/10.2337/db07-0299

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Online Letters to the Editor

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Comment on: Edghill et al. (2008) Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood: Diabetes 57:1034–1042, 2008
Sten A. Ivarsson and Åke Lernmark

Diabetes 2008 May; 57 (5): e9. https://doi.org/10.2337/db08-0091

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Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014–3019, 2007
Petra-Susanne Klein

Diabetes 2008 May; 57 (5): e10. https://doi.org/10.2337/db08-0173

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Response to Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014–3019, 2007
Joseph DiChiara, Kevin P. Bliden, Udaya S. Tantry, Miruais S. Hamed, Mark J. Antonino, Thomas A. Suarez, Oscar Bailon, Anand Singla and Paul A. Gurbel

Diabetes 2008 May; 57 (5): e11. https://doi.org/10.2337/db08-0250

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Table of Contents

Commentaries

Editorial

Metabolism

Signal Transduction

Obesity Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics

Online Letters to the Editor

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